Pharmacology and Therapeutics - Research Publications
Now showing items 1-10 of 252
Prognostic and Mechanistic Potentialof Progesterone Sulfates inIntrahepatic Cholestasis of Pregnancyand Pruritus Gravidarum
(John Wiley & Sons Inc., 2016)
Queensland Ambulance Service venomous injury
Mesenchymal stromal cell turnover in the normal adult lung revisited
(AMER PHYSIOLOGICAL SOC, 2013-11-27)
We have employed a simple and robust noninvasive method of continuous in vivo long-term bromodeoxyuridine (BrdU) labeling to analyze lung mesenchymal stromal cell turnover in adult mice in the steady state. Mathematical ...
Novel Small Airway Bronchodilator Responses to Rosiglitazone in Mouse Lung Slices
(AMER THORACIC SOC, 2014-04-27)
There is a need to identify novel agents that elicit small airway relaxation when beta(2)-adrenoceptor agonists become ineffective in difficult-to-treat asthma. Because chronic treatment with the synthetic peroxisome ...
Transforming Growth Factor-beta-Induced Differentiation of Airway Smooth Muscle Cells Is Inhibited by Fibroblast Growth Factor-2
(AMER THORACIC SOC, 2013-03-27)
In asthma, basic fibroblast growth factor (FGF-2) plays an important (patho) physiological role. This study examines the effects of FGF-2 on the transforming growth factor-beta (TGF-beta)-stimulated differentiation of ...
Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-beta 1
(BIOMED CENTRAL LTD, 2014)
Background: We have previously shown that transforming growth factor-beta (TGF-beta) impairs glucocorticoid (GC) function in pulmonary epithelial cell-lines. However, the signalling cascade leading to this impairment is ...
Rosiglitazone is a superior bronchodilator compared to chloroquine and beta-adrenoceptor agonists in mouse lung slices
(BIOMED CENTRAL LTD, 2014)
Background: Current therapy for relieving bronchoconstriction may be ineffective in severe asthma, particularly in the small airways. The aim of this study was to further characterise responses to the recently identified ...
LysoTracker is a marker of differentiated alveolar type II cells
(BIOMED CENTRAL LTD, 2013)
Background: LysoTracker Green DND-26 is a fluorescent dye that stains acidic compartments in live cells and has been shown to selectively accumulate in lamellar bodies in alveolar type II (AT2) cells in the lung. The aim ...
Differential Effects of Allergen Challenge on Large and Small Airway Reactivity in Mice
(PUBLIC LIBRARY SCIENCE, 2013)
The relative contributions of large and small airways to hyperresponsiveness in asthma have yet to be fully assessed. This study used a mouse model of chronic allergic airways disease to induce inflammation and remodelling ...
PPAR gamma Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy
(HINDAWI PUBLISHING CORPORATION, 2012)
In asthma, the increase in airway smooth muscle (ASM) can contribute to inflammation, airway wall remodeling and airway hyperresponsiveness (AHR). Targetting peroxisome proliferator-activated receptor gamma (PPAR gamma.), ...