Glucocorticoids (GCs) remain the frontline treatment in the management of chronic inflammatory diseases, as they are the most potent and effective anti-inflammatory agents available so far. However, impaired responses ...

Understanding transition metal dys/homeostasis holds potential for the discovery of new treatments to curb the increasing burden of cardio- and cerebrovascular diseases. However, their pharmacology and roles in the ...

Traumatic brain injury (TBI) is a socioeconomic burden and the underlying mechanisms that govern iron homeostasis after TBI is not fully elucidated. Evidently, iron accumulation observed after injury can contribute to the ...

Glucocorticoids remain central to treatment regimens for chronic airway inflammatory diseases, but the therapeutic responses are often limited by impaired responses in severe diseases. Glucocorticoid activity can be ...

Stress induced relapse and stressful emotional responses occurring during drug withdrawal are common problems for drug addicts. The relaxin-3/relaxin family peptide receptor 3 (RXFP3) system modulates stress responses and ...

Transition metals such as iron and copper are essential for life and health and yet can cause toxicity through oxidative damage. Therefore, regulation of the levels and location of transition metals is of critical importance ...

Immune cells such as mast cells and macrophages play important roles in initiating, perpetuating, and resolving inflammation. These cells release soluble factors that mediate the common features of inflammation in both ...

The underlying cause of asthma is yet to be determined. Asthma is presently the most common chronic disease affecting children, and it is becoming clear that disease originates in early life and as a result of complex ...

Chrysaora jellyfish (Class Scyphozoa) are considered mild to severe stingers. In particular, Chrysaora fuscescens and Chrysaora quinquecirrha are known for their ability to inflict painful stings that cause both localised ...

Glucocorticoids are the most effective treatment for long-term control of asthma. However, a subset of patients require a much higher dose of glucocorticoids to achieve the effect of of treatment, and even the ceiling ...