Pharmacology and Therapeutics - Theses
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Development and application of advanced bioimaging techniques to investigate stress pathways and drug action in neurodegeneration
Neurodegenerative diseases such as Frontotemporal Dementia (FTD), and Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neuron Disease (MND), have limited therapeutics available, placing a high demand on healthcare ...
Investigating Aβ toxicity and binding to neurons from differentiated human stem cells
Alzheimer’s disease (AD) is a neurodegenerative disease that is pathologically characterized by abnormal deposition of extracellular amyloid plaques and intraneuronal neurofibrillary tangles. The deposition of these ...
Investigating the role of Amyloid Precursor-Like Protein 2 in Motor Neurone Disease
Motor neurone disease (MND) is a fatal human neurodegenerative disorder. The most common form of MND is amyotrophic lateral sclerosis (ALS). MND is characterised by the progressive destruction of motor neurons in the central ...
Molecular basis for amyloid precursor protein mediated neuroprotection in traumatic brain injury
Amyloid precursor protein (APP) is neuroprotective in traumatic brain injury (TBI). Treatment with soluble amyloid precursor protein (sAPP) can rescue motor and cognitive deficits following TBI in mouse and rat models ...
Stiffness: a master regulator of fibrogenesis?
Fibrosis is one of the leading causes of death that may affect all organs in the human body. All forms of fibrosis are characterized by fibrotic scarring resulting from replacement of normal tissue with extracellular matrix ...
A novel role for STING-mediated type-I IFN response in traumatic brain injury
Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuro-inflammation and autophagy dysfunction contributes to cellular damage. Stimulator of interferon genes (STING)-induced ...
Development of novel therapeutic approaches for treatment of Alzheimer's disease
AD is a complex disease, involving the perturbation of multiple interrelated biological pathways. Despite being the most common form of neurodegenerative disease, with the number of patients expected to increase drastically, ...
Expression and function of the novel membrane-spanning protein, MS4A8B, in the human airways
The airway epithelium is an important barrier interface that protects the lungs against environmental insults and pathogens. Airway epithelial cells are increasingly recognized as key regulators of lung immune homeostasis ...
Novel insights into mechanisms of glucocorticoid actions and sensitivity in the airway epithelium
Glucocorticoids (GCs) remain the frontline treatment in the management of chronic inflammatory diseases, as they are the most potent and effective anti-inflammatory agents available so far. However, impaired responses ...
Investigation of transition metal pharmacology in the cardiovascular system
Understanding transition metal dys/homeostasis holds potential for the discovery of new treatments to curb the increasing burden of cardio- and cerebrovascular diseases. However, their pharmacology and roles in the ...