Pharmacology and Therapeutics - Theses
Now showing items 1-10 of 52
Expression and function of the novel membrane-spanning protein, MS4A8B, in the human airways
The airway epithelium is an important barrier interface that protects the lungs against environmental insults and pathogens. Airway epithelial cells are increasingly recognized as key regulators of lung immune homeostasis ...
Novel insights into mechanisms of glucocorticoid actions and sensitivity in the airway epithelium
Glucocorticoids (GCs) remain the frontline treatment in the management of chronic inflammatory diseases, as they are the most potent and effective anti-inflammatory agents available so far. However, impaired responses ...
Investigation of transition metal pharmacology in the cardiovascular system
Understanding transition metal dys/homeostasis holds potential for the discovery of new treatments to curb the increasing burden of cardio- and cerebrovascular diseases. However, their pharmacology and roles in the ...
Understanding the contribution of iron in traumatic brain injury (TBI)
Traumatic brain injury (TBI) is a socioeconomic burden and the underlying mechanisms that govern iron homeostasis after TBI is not fully elucidated. Evidently, iron accumulation observed after injury can contribute to the ...
A novel non-canonical pathway with potential for safer modulation of TGF-beta1 in steroid-resistant airway diseases
Glucocorticoids remain central to treatment regimens for chronic airway inflammatory diseases, but the therapeutic responses are often limited by impaired responses in severe diseases. Glucocorticoid activity can be ...
Characterization and stress induced modulations of RXFP3+ neurons in the mouse BNST
Stress induced relapse and stressful emotional responses occurring during drug withdrawal are common problems for drug addicts. The relaxin-3/relaxin family peptide receptor 3 (RXFP3) system modulates stress responses and ...
Modulating copper metabolism as a strategy to treat neurodegenerative tauopathies
Transition metals such as iron and copper are essential for life and health and yet can cause toxicity through oxidative damage. Therefore, regulation of the levels and location of transition metals is of critical importance ...
Characterisation of macrophage capping protein as a novel inflammatory mediator
Immune cells such as mast cells and macrophages play important roles in initiating, perpetuating, and resolving inflammation. These cells release soluble factors that mediate the common features of inflammation in both ...
Exploring the role of early life respiratory infection in asthma
The underlying cause of asthma is yet to be determined. Asthma is presently the most common chronic disease affecting children, and it is becoming clear that disease originates in early life and as a result of complex ...
Transcriptomic, proteomic and biological analyses of venom proteins from two Chrysaora jellyfish
Chrysaora jellyfish (Class Scyphozoa) are considered mild to severe stingers. In particular, Chrysaora fuscescens and Chrysaora quinquecirrha are known for their ability to inflict painful stings that cause both localised ...