Amyloid precursor protein (APP) is neuroprotective in traumatic brain injury (TBI). Treatment with soluble amyloid precursor protein (sAPP) can rescue motor and cognitive deficits following TBI in mouse and rat models ...

Fibrosis is one of the leading causes of death that may affect all organs in the human body. All forms of fibrosis are characterized by fibrotic scarring resulting from replacement of normal tissue with extracellular matrix ...

Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuro-inflammation and autophagy dysfunction contributes to cellular damage. Stimulator of interferon genes (STING)-induced ...

AD is a complex disease, involving the perturbation of multiple interrelated biological pathways. Despite being the most common form of neurodegenerative disease, with the number of patients expected to increase drastically, ...

The airway epithelium is an important barrier interface that protects the lungs against environmental insults and pathogens. Airway epithelial cells are increasingly recognized as key regulators of lung immune homeostasis ...

Glucocorticoids (GCs) remain the frontline treatment in the management of chronic inflammatory diseases, as they are the most potent and effective anti-inflammatory agents available so far. However, impaired responses ...

Understanding transition metal dys/homeostasis holds potential for the discovery of new treatments to curb the increasing burden of cardio- and cerebrovascular diseases. However, their pharmacology and roles in the ...

Traumatic brain injury (TBI) is a socioeconomic burden and the underlying mechanisms that govern iron homeostasis after TBI is not fully elucidated. Evidently, iron accumulation observed after injury can contribute to the ...

Glucocorticoids remain central to treatment regimens for chronic airway inflammatory diseases, but the therapeutic responses are often limited by impaired responses in severe diseases. Glucocorticoid activity can be ...

Stress induced relapse and stressful emotional responses occurring during drug withdrawal are common problems for drug addicts. The relaxin-3/relaxin family peptide receptor 3 (RXFP3) system modulates stress responses and ...