Pharmacology and Therapeutics - Theses
Now showing items 1-10 of 56
Molecular basis for amyloid precursor protein mediated neuroprotection in traumatic brain injury
Amyloid precursor protein (APP) is neuroprotective in traumatic brain injury (TBI). Treatment with soluble amyloid precursor protein (sAPP) can rescue motor and cognitive deficits following TBI in mouse and rat models ...
Stiffness: a master regulator of fibrogenesis?
Fibrosis is one of the leading causes of death that may affect all organs in the human body. All forms of fibrosis are characterized by fibrotic scarring resulting from replacement of normal tissue with extracellular matrix ...
A novel role for STING-mediated type-I IFN response in traumatic brain injury
Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuro-inflammation and autophagy dysfunction contributes to cellular damage. Stimulator of interferon genes (STING)-induced ...
Development of novel therapeutic approaches for treatment of Alzheimer's disease
AD is a complex disease, involving the perturbation of multiple interrelated biological pathways. Despite being the most common form of neurodegenerative disease, with the number of patients expected to increase drastically, ...
Expression and function of the novel membrane-spanning protein, MS4A8B, in the human airways
The airway epithelium is an important barrier interface that protects the lungs against environmental insults and pathogens. Airway epithelial cells are increasingly recognized as key regulators of lung immune homeostasis ...
Novel insights into mechanisms of glucocorticoid actions and sensitivity in the airway epithelium
Glucocorticoids (GCs) remain the frontline treatment in the management of chronic inflammatory diseases, as they are the most potent and effective anti-inflammatory agents available so far. However, impaired responses ...
Investigation of transition metal pharmacology in the cardiovascular system
Understanding transition metal dys/homeostasis holds potential for the discovery of new treatments to curb the increasing burden of cardio- and cerebrovascular diseases. However, their pharmacology and roles in the ...
Understanding the contribution of iron in traumatic brain injury (TBI)
Traumatic brain injury (TBI) is a socioeconomic burden and the underlying mechanisms that govern iron homeostasis after TBI is not fully elucidated. Evidently, iron accumulation observed after injury can contribute to the ...
A novel non-canonical pathway with potential for safer modulation of TGF-beta1 in steroid-resistant airway diseases
Glucocorticoids remain central to treatment regimens for chronic airway inflammatory diseases, but the therapeutic responses are often limited by impaired responses in severe diseases. Glucocorticoid activity can be ...
Characterization and stress induced modulations of RXFP3+ neurons in the mouse BNST
Stress induced relapse and stressful emotional responses occurring during drug withdrawal are common problems for drug addicts. The relaxin-3/relaxin family peptide receptor 3 (RXFP3) system modulates stress responses and ...