Anatomy and Neuroscience - Research Publications
Now showing items 1-10 of 314
Adenosine triphosphate-induced photoreceptor death and retinal remodeling in rats
Many common causes of blindness involve the death of retinal photoreceptors, followed by progressive inner retinal cell remodeling. For an inducible model of retinal degeneration to be useful, it must recapitulate these ...
Adult hippocampal neurogenesis, Rho kinase inhibition and enhancement of neuronal survival
Adult neurogenesis occurs throughout life; however the majority of new neurons do not survive. Enhancing the survival of these new neurons will increase the likelihood that these neurons could return function following ...
Expression and function of cell adhesion molecules during neural crest migration
Neural crest cells are highly migratory cells that give rise to many derivatives including peripheral ganglia, craniofacial structures and melanocytes. Neural crest cells migrate along defined pathways to their target ...
Resequencing and fine-mapping of the chromosome 12q13-14 locus associated with multiple sclerosis refines the number of implicated genes
(OXFORD UNIV PRESS, 2013-06-27)
Multiple sclerosis (MS) is a common chronic inflammatory disease of the central nervous system. Susceptibility to the disease is affected by both environmental and genetic factors. Genetic factors include haplotypes in the ...
Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF
J. Neurochem. (2012) 122, 523536. Abstract The nerve growth factor (NGF) precursor, proNGF, is implicated in various neuropathological states. ProNGF signals apoptosis by forming a complex with the receptors p75 and sortilin, ...
Myelin Gene Regulatory Factor Is Required for Maintenance of Myelin and Mature Oligodendrocyte Identity in the Adult CNS
(SOC NEUROSCIENCE, 2012-09-27)
Although the transcription factors required for the generation of oligodendrocytes and CNS myelination during development have been relatively well established, it is not known whether continued expression of the same ...
Identity-by-Descent Mapping to Detect Rare Variants Conferring Susceptibility to Multiple Sclerosis
(PUBLIC LIBRARY SCIENCE, 2013)
Genome-wide association studies (GWAS) have identified around 60 common variants associated with multiple sclerosis (MS), but these loci only explain a fraction of the heritability of MS. Some missing heritability may be ...
Dynamic and Differential Regulation of Stem Cell FactOR APPFoxD3 in the Neural Crest Is Encrypted in the Genome
(PUBLIC LIBRARY SCIENCE, 2012)
The critical stem cell transcription factor FoxD3 is expressed by the premigratory and migrating neural crest, an embryonic stem cell population that forms diverse derivatives. Despite its important role in development and ...
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells
(Rockefeller University Press, 2013)
Mucosal-associated invariant T cells (MAIT cells) express a semi-invariant T cell receptor (TCR) alpha-chain, TRAV1-2-TRAJ33, and are activated by vitamin B metabolites bound by the major histocompatibility complex ...
The effect of photoreceptor degeneration on ganglion cell morphology
Retinitis pigmentosa refers to a family of inherited photoreceptor degenerations resulting in blindness. Well after the total loss of photoreceptors, neurons of the inner retina are known to undergo plastic changes. Here, ...