Anatomy and Neuroscience - Theses
Now showing items 1-10 of 87
Transcriptomic diversification along the monocyte-macrophage continuum.
Current models of innate immune responses describe hard wired, gene-centric signalling networks, with limited capacity to define the molecular mechanisms underpinning transcriptomic diversity. It is well established that ...
Development of in vitro and in vivo models for the study of myelin plasticity
The central nervous system (CNS) constantly responds to changes in environmental stimuli by undergoing structural and functional modifications. Some stimuli induce persistent CNS changes which in turn underpin adaptive ...
The effect of genetic susceptibility and immunosuppressant treatment on mononuclear cell phenotype in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). The immune system plays a significant role in the pathophysiology of the disease and research into the mechanisms that may ...
Regulation of Drosophila Myc transcription by the single stranded DNA/RNA binding proteins Psi and AGO1
MYC has wide-ranging functions, with potential to amplify transcriptional output to activate cell growth, metabolism and cell cycle progression, thus driving oncogenic programs. As even small increases in MYC abundance are ...
Using induced pluripotent stem cells to model primary open-angle glaucoma
Glaucoma is a group of optic neuropathies that may be characterized by gradual degeneration of retinal ganglion cells (RGCs) and their axons leading to irreversible vision loss [1, 2]. Glaucoma is the second leading cause ...
Cellular and subcellular co-storage of gastrointestinal hormones
Gastrointestinal hormones regulate a diverse range of physiological processes including digestion, metabolism, and food intake, as well as maintaining mucosal integrity and mounting defensive mechanism in response to ...
Determining the role of the paratrigeminal nucleus (Pa5) in airway defence
Respiratory sensations conveyed by airway sensory nerve fibres are poorly understood, yet they contribute significantly to morbidity in pulmonary disease. Our viral tracing studies identified a previously unknown airway ...
The transcription factor grainy head regulates intestinal stem cells
The constant renewal of the intestinal epithelium is achieved through the activity of a population of intestinal stem cells (ISC). These cells maintain tissue homeostasis by ensuring balance between cell division and the ...
The neurovascular unit in early diabetic retinopathy: cellular changes and an emerging role for microglia
In the developed world the leading cause of blindness in working age adults is diabetic retinopathy (DR). The risk of vision loss due to diabetes increases with disease duration, and most frequently affects those who have ...
Studies on mechanisms of cell death in retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinopathies affecting approximately 1.5 million people worldwide. RP is associated with genetic mutations leading to progressive deterioration of the ...