Anatomy and Neuroscience - Theses
Now showing items 1-10 of 79
The neurovascular unit in early diabetic retinopathy: cellular changes and an emerging role for microglia
In the developed world the leading cause of blindness in working age adults is diabetic retinopathy (DR). The risk of vision loss due to diabetes increases with disease duration, and most frequently affects those who have ...
Studies on mechanisms of cell death in retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinopathies affecting approximately 1.5 million people worldwide. RP is associated with genetic mutations leading to progressive deterioration of the ...
Suppressors of oncogenic Cbl in the Drosophila eye.
Cbl is an E3 ligase, and downregulates several cellular signalling pathways, in this role by targeting receptor tyrosine kinases for endocytosis. Mammalian Cbl was first identified as the full-length isoform of v-Cbl, a ...
Tau and beta-amyloid deposition, structural integrity, and cognitive function following traumatic brain injury in Australian war veterans
Background: Traumatic brain injury (TBI), has been diagnosed in over 355,000 US military service personnel since 2000. Epidemiological research indicates that veterans with TBI are two-to-four times more likely to develop ...
An investigation of intentionally modified crania in Georgia and Europe in the Migration Period (4th – 7th c AD)
This aim of this research is to examine the custom of intentional cranial modification in the Mtskheta region of Georgia during the Migration Period (4th ‒ 7th c AD) by comparing it with that in Europe, particularly ...
Tackling bone pain at the source: identifying and exploring new therapeutic targets
Pain associated with bone pathology puts a significant burden (both in terms of quality of life and cost) on individuals, society, and the health care system in Australia and worldwide. Current strategies for management ...
Characterisation of innate immune gene activities in rested and stimulated states
Monocytes and macrophages are among the first line of response to an infectious agent. The quality of this response will influence the type of T-lymphocyte recruited and may determine the outcome of an infection. While ...
ESRP1 is a novel marker of germ cell development and gonadal cancer
Alternative splicing (AS) plays critical roles in controlling developmental programs. To date, there is evident that many genes splice differently during gametogenesis. Since disruption in AS may result in various reproductive ...
The oncogenic interplay between Hepatitis B virus proteins and Wnt signalling
Liver cancer is the sixth most common cancer worldwide, and is ranked fourth for the number of cancer-related mortality. The vast majority of liver cancer cases are hepatocellular carcinoma (HCC) where viral hepatitis ...
The role of the TOB1 protein in gametogenesis
Previous studies indicate that TOB1 plays important roles in some cellular processes such as cell proliferation, apoptosis and tumour suppression. Gametogenesis in mammals relies on a series of complex processes that involve ...