Anatomy and Neuroscience - Theses
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Regulation of Drosophila Myc transcription by the single stranded DNA/RNA binding proteins Psi and AGO1
MYC has wide-ranging functions, with potential to amplify transcriptional output to activate cell growth, metabolism and cell cycle progression, thus driving oncogenic programs. As even small increases in MYC abundance are ...
Using induced pluripotent stem cells to model primary open-angle glaucoma
Glaucoma is a group of optic neuropathies that may be characterized by gradual degeneration of retinal ganglion cells (RGCs) and their axons leading to irreversible vision loss [1, 2]. Glaucoma is the second leading cause ...
Cellular and subcellular co-storage of gastrointestinal hormones
Gastrointestinal hormones regulate a diverse range of physiological processes including digestion, metabolism, and food intake, as well as maintaining mucosal integrity and mounting defensive mechanism in response to ...
Determining the role of the paratrigeminal nucleus (Pa5) in airway defence
Respiratory sensations conveyed by airway sensory nerve fibres are poorly understood, yet they contribute significantly to morbidity in pulmonary disease. Our viral tracing studies identified a previously unknown airway ...
The transcription factor grainy head regulates intestinal stem cells
The constant renewal of the intestinal epithelium is achieved through the activity of a population of intestinal stem cells (ISC). These cells maintain tissue homeostasis by ensuring balance between cell division and the ...
The neurovascular unit in early diabetic retinopathy: cellular changes and an emerging role for microglia
In the developed world the leading cause of blindness in working age adults is diabetic retinopathy (DR). The risk of vision loss due to diabetes increases with disease duration, and most frequently affects those who have ...
Studies on mechanisms of cell death in retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinopathies affecting approximately 1.5 million people worldwide. RP is associated with genetic mutations leading to progressive deterioration of the ...
Suppressors of oncogenic Cbl in the Drosophila eye.
Cbl is an E3 ligase, and downregulates several cellular signalling pathways, in this role by targeting receptor tyrosine kinases for endocytosis. Mammalian Cbl was first identified as the full-length isoform of v-Cbl, a ...
Tau and beta-amyloid deposition, structural integrity, and cognitive function following traumatic brain injury in Australian war veterans
Background: Traumatic brain injury (TBI), has been diagnosed in over 355,000 US military service personnel since 2000. Epidemiological research indicates that veterans with TBI are two-to-four times more likely to develop ...
An investigation of intentionally modified crania in Georgia and Europe in the Migration Period (4th – 7th c AD)
This aim of this research is to examine the custom of intentional cranial modification in the Mtskheta region of Georgia during the Migration Period (4th ‒ 7th c AD) by comparing it with that in Europe, particularly ...