Physiology - Theses
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Characterisation of synaptic transmission and angiotensin II type 1A receptor activity at nucleus of the solitary tract neurons
The ability to sense changes in the body and external environment, and to undertake appropriate physiological responses is essential for survival. Cranial visceral afferents continuously monitor the state of visceral organs ...
Dietary fatty acids and the heart
This Thesis is presented in the form of a compilation comprising 3 peer-reviewed research papers. Each paper is abstracted as below. PUBLICATION #1 Ip WTK, Huggins CE, Pepe S, Delbridge LMD. Evaluating RNA preparation ...
Diabetic cardiomyopathy: sex-specific aspects of functional, structural and molecular remodelling
Background: Clinical studies have revealed increased cardiovascular risk in diabetic patients, which is substantially elevated in women. Perplexingly, while there has been extensive experimental effort in characterising ...
The role of submucosal neurons in physiological and pathophysiological intestinal secretion
The enteric nervous system (ENS) has two major types of secretomotor neurons, which contain either acetylcholine (i.e. are cholinergic) or vasoactive intestinal peptide (VIP). These are well conserved across species, and ...
Influence of maternal stress during pregnancy in females born small on maternal and offspring metabolic health
Uteroplacental insufficiency remains the leading cause of intrauterine growth restriction in the western world, leading to babies born with low birth weight. These individuals are programmed for an increased lifetime risk ...
Identification of the phenotype of the angiotensin II type 1A receptor-expressing neurons involved in modulating the baroreceptor-heart rate reflex
Blood pressure (BP) regulation requires a complex interaction between different physiological systems to ensure adequate tissue blood flow under different physiological conditions. One of these is the baroreceptor reflex ...
Characterising the clinical potential of the heat shock protein co-inducer BGP-15 for Duchenne muscular dystrophy
DMD is a severe X-liked muscle wasting disorder affecting 1:3,600-6,000 live male births worldwide annually [3-5]. Individuals suffering from the disorder possess mutations in the dystrophin (dmd) gene that renders skeletal ...
Combinatorial gene therapy as an intervention for Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a disease that deprives young children of the ability to walk and considerably reduces their quality of life. DMD is a progressive disorder with affected toddlers having difficulty in ...
Sexual dimorphic effect of Cholera Toxin on colonic motility
Diarrhea is a combination of hypersecretion and increased gut motility. Bacterial toxins such as cholera toxin (CT) are a main cause of diarrhea around the world creating life threatening outbreaks. Although the effect ...