Physiology - Theses
Now showing items 1-10 of 53
The effect of early life antibiotic exposure on the development of the gut microbiota and enteric nervous system
Early postnatal life is a critical stage of microbiota establishment and ENS development. While the initial postnatal stage from birth is fundamental for the development of the gut microbiota and ENS, weaning is another ...
Characterising cellular and molecular mechanisms of cardiac diastolic dysfunction
Background: Diastolic dysfunction is an important contributor to many cardiac pathologies including diabetic cardiomyopathy and heart failure with preserved ejection fraction. It is characterised by ventricular stiffness, ...
Synaptic mechanisms and function in the mouse enteric nervous system
Virtually all functions of the enteric nervous system (ENS) rely on synaptic transmission, which occurs at specialised sites referred to as synapses. Molecular mechanisms behind synaptic transmission at central synapses ...
The metabolic microenvironment regulates myogenic fate decisions through altered histone acetylation
1. Skeletal muscle has an extensive capacity for regeneration, a property conferred on this tissue by a resident population of skeletal muscle stem cells (MuSCs). Any impairment to this population of stem cells can lead ...
Adipose, sex steroids and atrial arrhythmia vulnerability
Background: Pericardial adipose deposition occurs in ageing and obesity, and independently contributes to the development of atrial fibrillation. The mechanisms underlying this association are not yet understood. ...
Chronic ephedrine administration decreases brown adipose tissue activity in a randomised controlled human trial: implications for obesity
Aim Activation of Brown Adipose Tissue (BAT) may have therapeutic potential to combat obesity. Acute treatment of mice with sympathomimetic drugs activates BAT thermogenesis, and chronic treatment increases BAT thermogenic ...
Investigating cortical oscillations, coherence and seizure susceptibility in a mouse model of autism
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder diagnosed by difficulties in social communication, repetitive behaviour and/or restricted interests. A high proportion of ASD patients also experience ...
Metabolic and cardiorenal adaptations to pregnancy in females born small on a high fat diet and benefits of endurance exercise training
Uteroplacental insufficiency is the major cause of intrauterine growth restriction in Western society and is often associated with adult metabolic, cardiovascular and renal diseases. Recent studies have reported that these ...
Neural mechanisms involved in enterotoxin- induced intestinal hypersecretion
Exotoxins of the bacteria Vibrio cholerae (cholera toxin, CT) and Clostridium difficile (C. diff., TcdA) induce rampant disease in the form of irresolvable diarrhoea causing rapid dehydration and potential death if left ...
Pathology of glycogen excess in diabetic cardiomyopathy
Background: Diabetic cardiomyopathy is a distinct cardiac pathology and the underlying mechanisms are unknown. Elevated glycogen content has been observed in the diabetic human myocardium, first recorded 80 years ago, ...