Surgery (Austin & Northern Health) - Research Publications
Now showing items 1-10 of 45
Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)
(ENDOCRINE SOC, 2012-07-27)
Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates tumor growth, but its effect on gastrin gene regulation has not been examined in detail. ...
A conceptual model for analysing informal learning in online social networks for health professionals.
Online social networking (OSN) provides a new way for health professionals to communicate, collaborate and share ideas with each other for informal learning on a massive scale. It has important implications for ongoing ...
Neoadjuvant capecitabine and oxaliplatin before chemoradiotherapy and total mesorectal excision in MRI-defined poor-risk rectal cancer: a phase 2 trial.
BACKGROUND: Patients with poor-risk rectal cancer defined by MRI can be at high risk of disease recurrence despite standard chemoradiotherapy and optimum surgery. We aimed to assess the safety and long-term efficacy of ...
Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter
(BIOSCIENTIFICA LTD, 2014-02-01)
Gastrin and its precursors act as growth factors for the normal and neoplastic gastrointestinal mucosa. As the hypoxia mimetic cobalt chloride upregulates the gastrin gene, the effect of other metal ions on gastrin promoter ...
Bimodal role of Kupffer cells during colorectal cancer liver metastasis
(LANDES BIOSCIENCE, 2013-07-01)
Kupffer cells (KCs) are resident liver macrophages that play a crucial role in liver homeostasis and in the pathogenesis of liver disease. Evidence suggests KCs have both stimulatory and inhibitory functions during tumor ...
The renin angiotensin system regulates Kupffer cells in colorectal liver metastases
(LANDES BIOSCIENCE, 2013-08-01)
Blockade of the renin angiotensin system (RAS) can inhibit tumor growth and this may be mediated via undefined immunomodulatory actions. This study investigated the effects of RAS blockade on liver macrophages (Kupffer ...
Increased gastrin gene expression provides a physiological advantage to mice under hypoxic conditions
(AMER PHYSIOLOGICAL SOC, 2015-01-15)
Hypoxia, or a low concentration of O2, is encountered in humans undertaking activities such as mountain climbing and scuba diving and is important pathophysiologically as a limiting factor in tumor growth. Although data ...
A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
(BIOMED CENTRAL LTD, 2013-04-20)
BACKGROUND: The CCR5 antagonist maraviroc (MVC) inhibits human immunodeficiency virus type 1 (HIV-1) entry by altering the CCR5 extracellular loops (ECL), such that the gp120 envelope glycoproteins (Env) no longer recognize ...