Surgery (Austin & Northern Health) - Research Publications
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Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)
(ENDOCRINE SOC, 2012-07-27)
Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates tumor growth, but its effect on gastrin gene regulation has not been examined in detail. ...
Multidisciplinary Treatment and Survival of Patients with Vertebral Metastases from Thyroid Carcinoma
(MARY ANN LIEBERT, INC, 2012-02-01)
BACKGROUND: Distant metastases from differentiated thyroid carcinoma occur in up to 20% of cases and represent the most frequent cause of thyroid cancer-related death. Metastatic disease to the spine has the potential to ...
An in vivo mouse model of intraosseous spinal cancer causing evolving paraplegia
(SPRINGER, 2013-11-01)
The spine is the commonest site of skeletal metastatic disease and uncontrolled growth of cancer in the spine will inevitably cause pain and neurologic compromise. Improved understanding of the pathobiology behind this ...
Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of beta-Synuclein as a Potential CHK Physiological Substrate
(AMER CHEMICAL SOC, 2011-08-09)
C-Terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor function by phosphorylating the C-terminal regulatory tyrosine of the Src-family kinases (SFKs). The phosphorylation suppresses their activity and ...
Analysing Health Professionals' Learning Interactions in an Online Social Network: A Longitudinal Study
(IOS PRESS, 2016-01-01)
This paper summarises a longitudinal analysis of learning interactions occurring over three years among health professionals in an online social network. The study employs the techniques of Social Network Analysis (SNA) ...
Using Routine Hemoglobin A1c Testing to Determine the Glycemic Status in Psychiatric Inpatients
(FRONTIERS MEDIA SA, 2017-03-28)
AIM: Using routine hemoglobin A1c (HbA1c) testing to describe the prevalence, characteristics, and length of stay (LOS) of psychiatry inpatients with type 2 diabetes compared to those with pre-diabetes and those without ...
Outcomes of contemporary management of gangrenous and non-gangrenous acute cholecystitis
(WILEY-BLACKWELL, 2011-08-01)
BACKGROUND: Gangrenous cholecystitis (GC) is considered a more severe form of acute cholecystitis. The risk factors associated with this condition and its impact on morbidity and mortality compared with those of non-gangrenous ...
Altered significance of D'Amico risk classification in patients with prostate cancer linked to a familial breast cancer (kConFab) cohort
(WILEY-BLACKWELL, 2015-08-01)
OBJECTIVE: To ascertain whether D'Amico risk classification is an accurate discriminator of prostate cancer mortality risk in BRCA2 pathogenic mutation carriers and non-carriers from a familial breast cancer cohort. PATIENTS ...
Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments
(BIOMED CENTRAL LTD, 2012-11-15)
BACKGROUND: Treatment of solid tumors with vascular disrupting agent OXi4503 results in over 90% tumor destruction. However, a thin rim of viable cells persists in the tumor periphery following treatment, contributing to ...
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