Surgery (Austin & Northern Health) - Research Publications
Now showing items 1-10 of 48
Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)
(ENDOCRINE SOC, 2012-07-27)
Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates tumor growth, but its effect on gastrin gene regulation has not been examined in detail. ...
The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity
(AMER DIABETES ASSOC, 2012-05-01)
Liver fructose-1,6-bisphosphatase (FBPase) is a regulatory enzyme in gluconeogenesis that is elevated by obesity and dietary fat intake. Whether FBPase functions only to regulate glucose or has other metabolic consequences ...
Analysis of the platypus genome suggests a transposon origin for mammalian imprinting
(BIOMED CENTRAL LTD, 2009-01-01)
BACKGROUND: Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene expression. Many hypotheses have been advanced to explain why genomic imprinting evolved in mammals, but few have examined how it ...
A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations
(BIOMED CENTRAL LTD, 2013-04-20)
BACKGROUND: The CCR5 antagonist maraviroc (MVC) inhibits human immunodeficiency virus type 1 (HIV-1) entry by altering the CCR5 extracellular loops (ECL), such that the gp120 envelope glycoproteins (Env) no longer recognize ...
Ketosis and appetite-mediating nutrients and hormones after weight loss
(NATURE PUBLISHING GROUP, 2013-07-01)
BACKGROUND/OBJECTIVES: Diet-induced weight loss is accompanied by compensatory changes, which increase appetite and encourage weight regain. There is some evidence that ketogenic diets suppress appetite. The objective is ...
Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of beta-Synuclein as a Potential CHK Physiological Substrate
(AMER CHEMICAL SOC, 2011-08-09)
C-Terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor function by phosphorylating the C-terminal regulatory tyrosine of the Src-family kinases (SFKs). The phosphorylation suppresses their activity and ...
A conceptual model for analysing informal learning in online social networks for health professionals.
Online social networking (OSN) provides a new way for health professionals to communicate, collaborate and share ideas with each other for informal learning on a massive scale. It has important implications for ongoing ...
Activation of Src family tyrosine kinases by ferric ions
(ELSEVIER SCIENCE BV, 2014-03-01)
The Src-family tyrosine kinases (SFKs) are oncogenic enzymes that contribute to the initiation and progression of many types of cancer. In normal cells, SFKs are kept in an inactive state mainly by phosphorylation of a ...
Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases
(ELSEVIER IRELAND LTD, 2014-05-01)
Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, ...