Surgery (Austin & Northern Health) - Research Publications
Now showing items 1-10 of 58
Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)
(ENDOCRINE SOC, 2012-07-27)
Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates tumor growth, but its effect on gastrin gene regulation has not been examined in detail. ...
p21-activated kinases and gastrointestinal cancer
(ELSEVIER SCIENCE BV, 2013-01-01)
p21-activated kinases (PAKs) were initially identified as effector proteins downstream from GTPases of the Rho family. To date, six members of the PAK family have been discovered in mammalian cells. PAKs play important ...
Zinc ions upregulate the hormone gastrin via an E-box motif in the proximal gastrin promoter
(BIOSCIENTIFICA LTD, 2014-02-01)
Gastrin and its precursors act as growth factors for the normal and neoplastic gastrointestinal mucosa. As the hypoxia mimetic cobalt chloride upregulates the gastrin gene, the effect of other metal ions on gastrin promoter ...
p-21-Activated kinase 1 mediates gastrin-stimulated proliferation in the colorectal mucosa via multiple signaling pathways
(AMER PHYSIOLOGICAL SOC, 2013-03-01)
Gastrins, including amidated (Gamide) and glycine-extended (Ggly) forms, function as growth factors for the gastrointestinal mucosa. The p-21-activated kinase 1 (PAK1) plays important roles in growth factor signaling ...
P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1 alpha
(ELSEVIER IRELAND LTD, 2013-10-28)
P21 activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin and Ras oncogene, which promote CRC survival via stimulation of hypoxia-inducible factor 1α (HIF-1α). The aim of this ...
Melatonin supplementation in patients with complete tetraplegia and poor sleep.
People with complete tetraplegia have interrupted melatonin production and commonly report poor sleep. Whether the two are related is unclear. This pilot study investigated whether nightly supplementation of 3 mg melatonin ...
The Role of Hypoxia-Inducible Factor 1 alpha in Determining the Properties of Castrate-Resistant Prostate Cancers
(PUBLIC LIBRARY SCIENCE, 2013-01-16)
BACKGROUND: Castrate-resistant prostate cancer (CRPC) is a lethal condition in patients receiving androgen deprivation therapy for prostate cancer (PC). Despite numerous studies showing the expression of HIF1α protein under ...
The C-terminal flanking peptide of progastrin induces gastric cell apoptosis and stimulates colonic cell division in vivo
(ELSEVIER SCIENCE INC, 2013-08-01)
Progastrin (PG) is processed into a number of smaller peptides including amidated gastrin (Gamide), non-amidated glycine-extended gastrin (Ggly) and the C-terminal flanking peptide (CTFP). Several groups have reported that ...
Prevention of hypothermia in patients undergoing orthotopic liver transplantation using the humigard (R) open surgery humidification system: a prospective randomized pilot and feasibility clinical trial
(BIOMED CENTRAL LTD, 2017-01-23)
BACKGROUND: Perioperative thermal disturbances during orthotopic liver transplantation (OLT) are common. We hypothesized that in patients undergoing OLT the use of a humidified high flow CO2 warming system maintains higher ...