Surgery (Austin & Northern Health) - Research Publications

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Induction of Gastrin Expression in Gastrointestinal Cells by Hypoxia or Cobalt Is Independent of Hypoxia-Inducible Factor (HIF)

Xiao, Lin; Kovac, Suzana; Chang, Mike; Shulkes, Arthur; Baldwin, Graham S.; Patel, Oneel (ENDOCRINE SOC, 2012-07-27)

Gastrin and its precursors have been shown to promote mitogenesis and angiogenesis in gastrointestinal tumors. Hypoxia stimulates tumor growth, but its effect on gastrin gene regulation has not been examined in detail. ...

Isolation and characterisation of the ovine gastrin-releasing peptide gene; abundant expression in the pregnant uterus and selective expression in fetal tissues

WHITLEY, JANE; MOORE, CAROLINE; GIRAUD, ANDREW SIMON; SHULKES, ARTHUR AARON (2002)

Multidisciplinary Treatment and Survival of Patients with Vertebral Metastases from Thyroid Carcinoma

Quan, GMY; Pointillart, V; Palussiere, J; Bonichon, F (MARY ANN LIEBERT, INC, 2012-02-01)

BACKGROUND: Distant metastases from differentiated thyroid carcinoma occur in up to 20% of cases and represent the most frequent cause of thyroid cancer-related death. Metastatic disease to the spine has the potential to ...

An in vivo mouse model of intraosseous spinal cancer causing evolving paraplegia

Cossigny, DAF; Mouhtouris, E; Dushyanthen, S; Gonzalvo, A; Quan, GMY (SPRINGER, 2013-11-01)

The spine is the commonest site of skeletal metastatic disease and uncontrolled growth of cancer in the spine will inevitably cause pain and neurologic compromise. Improved understanding of the pathobiology behind this ...

Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of beta-Synuclein as a Potential CHK Physiological Substrate

Ia, KK; Jeschke, GR; Deng, Y; Kamaruddin, MA; Williamson, NA; Scanlon, DB; Culvenor, JG; Hossain, MI; Purcell, AW; Liu, S; ... (AMER CHEMICAL SOC, 2011-08-09)

C-Terminal Src kinase-homologous kinase (CHK) exerts its tumor suppressor function by phosphorylating the C-terminal regulatory tyrosine of the Src-family kinases (SFKs). The phosphorylation suppresses their activity and ...

Analysing Health Professionals' Learning Interactions in an Online Social Network: A Longitudinal Study

Li, X; Verspoor, K; Gray, K; Barnett, S (IOS PRESS, 2016-01-01)

This paper summarises a longitudinal analysis of learning interactions occurring over three years among health professionals in an online social network. The study employs the techniques of Social Network Analysis (SNA) ...

Using Routine Hemoglobin A1c Testing to Determine the Glycemic Status in Psychiatric Inpatients

Naidu, P; Churilov, L; Kong, A; Kanaan, R; Wong, H; Van Mourik, A; Yao, A; Cornish, E; Hachem, M; Hart, GK; ... (FRONTIERS MEDIA SA, 2017-03-28)

AIM: Using routine hemoglobin A1c (HbA1c) testing to describe the prevalence, characteristics, and length of stay (LOS) of psychiatry inpatients with type 2 diabetes compared to those with pre-diabetes and those without ...

Tyrosine modification increases the affinity of gastrin for ferric ions

Baldwin, GS; Sims, I (SPRINGER INTERNATIONAL PUBLISHING AG, 2015-12-24)

The peptide hormone gastrin17, which occurs naturally in both tyrosine sulphated and unsulphated forms, binds two ferric ions with pM affinities. The aim of this study was to investigate the hypothesis that sulphation or ...

Activation of Src family tyrosine kinases by ferric ions

Baldwin, GS; Lio, DS-S; Ferrand, A; Catimel, B; Shehan, BP; Norton, RS; Cheng, H-C (ELSEVIER SCIENCE BV, 2014-03-01)

The Src-family tyrosine kinases (SFKs) are oncogenic enzymes that contribute to the initiation and progression of many types of cancer. In normal cells, SFKs are kept in an inactive state mainly by phosphorylation of a ...

Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases

Yeo, D; Nhi, H; Beutler, JA; Christophi, C; Shulkes, A; Baldwin, GS; Nikfarjam, M; He, H (ELSEVIER IRELAND LTD, 2014-05-01)

Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, ...

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