Surgery (Austin & Northern Health) - Theses
Now showing items 1-10 of 31
Targeting p21-activated kinases in the treatment of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies worldwide, with a very poor prognosis and a 5-year survival rate less than 9%. This dismal outcome is largely due to lack of early diagnosis, ...
The effects of cannabinoid derivatives on pancreatic cancer
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant solid tumours and its treatment has not been efficiently improved during the last decade. The overall 5-year survival rate of ...
Communication, technology and instruments in the modern contemporary setting of urology
The 2017 Sensis Social Media Report demonstrated an increase in Australians being involved in Social Media Platform. About 84% of Australians access the Internet on a daily basis with higher usage among the age group under ...
The role of zinc in prostate cancer
Prostate cancer (PCa) is the most common cancer amongst Australian men. Zinc is an essential metal and is vital for normal function of the prostate gland. Castrate-resistant prostate cancer (CRPC) is becoming increasingly ...
Characterisation of tumour-infiltrating lymphocytes in benign and malignant prostate tissues
Over the past decade, we have seen a significant advancement in the treatment of metastatic castrate-resistant prostate cancer (PC). Cancer immunotherapy is now a reality, but the information on tumour infiltrating lymphocytes ...
18F-fluorodeoxyglucose positron emission tomography as a biomarker for colorectal cancer liver metastases
Background: Colorectal cancer is the second most common cause of cancer-related death in Australia. The majority of patients with colorectal cancer develop liver metastases but only those amenable for surgical resection ...
Role of p21-activated kinases in pancreatic cancer
Pancreatic cancer remains one of the most lethal of all solid tumours with an overall 5-year survival rate of 7%. Management has not improved significantly over the last thirty years and based on current trends, is expected ...
Selection and management of men for active surveillance in low risk prostate cancer
Aims: To investigate: 1. Selection of men for active surveillance of prostate cancer a. Validation of risk calculators b. Suitability for inclusion of Gleason 3+4 disease. 2. Performance of prostate biopsy during ...
The role of hypoxia inducible factor 1 alpha (HIF1α) in prostate cancer
Prostate cancer (PC) is one of the most prevalent cancers in men. Although many PCs are indolent, a significant proportion will metastasize and develop resistance to therapy. Contemporary screening tests lack the finesse ...
Thromboembolism and neoadjuvant chemoradiation for rectal cancer
Thromboembolism (TE) is one of the leading causes of morbidity and mortality in cancer, is an independent predictor of reduced survival, and the overall rate of TE in cancer patients is increasing. Assessing the TE risk ...