Surgery (Austin & Northern Health) - Theses
Now showing items 1-10 of 33
The oncological outcomes of dose escalated radiotherapy and its impact on biochemical control and toxicity in men with prostate cancers
Introduction: Radiation therapy (RT) for prostate cancer (PC) has steadily evolved over many years, with improvement in biochemical relapse free survival (bRFS). An association between overall survival and doses greater ...
Development of a cell-free DNA methodology to assess organ rejection after liver transplantation
Background: Liver transplantation has revolutionised the prognosis of patients with fulminant liver failure, chronic liver disease, and liver cancer. Although liver transplantation is safe, organ rejection is a common ...
Targeting p21-activated kinases in the treatment of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies worldwide, with a very poor prognosis and a 5-year survival rate less than 9%. This dismal outcome is largely due to lack of early diagnosis, ...
The effects of cannabinoid derivatives on pancreatic cancer
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant solid tumours and its treatment has not been efficiently improved during the last decade. The overall 5-year survival rate of ...
Communication, technology and instruments in the modern contemporary setting of urology
The 2017 Sensis Social Media Report demonstrated an increase in Australians being involved in Social Media Platform. About 84% of Australians access the Internet on a daily basis with higher usage among the age group under ...
The role of zinc in prostate cancer
Prostate cancer (PCa) is the most common cancer amongst Australian men. Zinc is an essential metal and is vital for normal function of the prostate gland. Castrate-resistant prostate cancer (CRPC) is becoming increasingly ...
Characterisation of tumour-infiltrating lymphocytes in benign and malignant prostate tissues
Over the past decade, we have seen a significant advancement in the treatment of metastatic castrate-resistant prostate cancer (PC). Cancer immunotherapy is now a reality, but the information on tumour infiltrating lymphocytes ...
18F-fluorodeoxyglucose positron emission tomography as a biomarker for colorectal cancer liver metastases
Background: Colorectal cancer is the second most common cause of cancer-related death in Australia. The majority of patients with colorectal cancer develop liver metastases but only those amenable for surgical resection ...
Role of p21-activated kinases in pancreatic cancer
Pancreatic cancer remains one of the most lethal of all solid tumours with an overall 5-year survival rate of 7%. Management has not improved significantly over the last thirty years and based on current trends, is expected ...
Selection and management of men for active surveillance in low risk prostate cancer
Aims: To investigate: 1. Selection of men for active surveillance of prostate cancer a. Validation of risk calculators b. Suitability for inclusion of Gleason 3+4 disease. 2. Performance of prostate biopsy during ...