Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice
AuthorSiebel, AL; Gehring, HM; Vodstrcil, L; Parry, LJ
EditorSherwood, OD; Fields, PA; Steinetz, BG
Source TitleRELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE
PublisherNEW YORK ACAD SCIENCES
University of Melbourne Author/sSIEBEL, ANDREW LLOYD; CLARK, HELEN; VODSTRCIL, LENKA ANNA; Parry, Laura; Siebel, Andrew
AffiliationSchool of BioSciences
Document TypeJournal Article
CitationsSiebel, A. L., Gehring, H. M., Vodstrcil, L. & Parry, L. J. (2005). Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice. RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE, 1041 (1), pp.104-109. https://doi.org/10.1196/annals.1282.014.
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Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ERalpha in Rlx+/+ mice at term was correlated with a decrease in ERbeta, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ERalpha expression, but it caused a significant decrease in ERbetas.
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