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Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice

dc.contributor.authorSiebel, AL
dc.contributor.authorGehring, HM
dc.contributor.authorVodstrcil, L
dc.contributor.authorParry, LJ
dc.contributor.editorSherwood, OD
dc.contributor.editorFields, PA
dc.contributor.editorSteinetz, BG
dc.date.available2017-10-04T00:59:10Z
dc.date.issued2005-01-01
dc.identifierpii: 1041/1/104
dc.identifier.citationSiebel, A. L., Gehring, H. M., Vodstrcil, L. & Parry, L. J. (2005). Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice. RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE, 1041 (1), pp.104-109. https://doi.org/10.1196/annals.1282.014.
dc.identifier.issn0077-8923
dc.identifier.urihttp://hdl.handle.net/11343/192568
dc.description.abstractRelaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx-/-) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice. An increase in ERalpha in Rlx+/+ mice at term was correlated with a decrease in ERbeta, which was not observed in Rlx-/- mice. Treatment of Rlx-/- mice with relaxin had no effect on OTR, LGR7, or ERalpha expression, but it caused a significant decrease in ERbetas.
dc.languageEnglish
dc.publisherNEW YORK ACAD SCIENCES
dc.titleOxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx(-/-)) mice
dc.typeJournal Article
dc.identifier.doi10.1196/annals.1282.014
melbourne.affiliation.departmentSchool of BioSciences
melbourne.affiliation.departmentZoology
melbourne.source.titleAnnals of the New York Academy of Sciences
melbourne.source.volume1041
melbourne.source.issue1
melbourne.source.pages104-109
melbourne.elementsid275286
melbourne.contributor.authorSIEBEL, ANDREW LLOYD
melbourne.contributor.authorCLARK, HELEN
melbourne.contributor.authorVODSTRCIL, LENKA ANNA
melbourne.contributor.authorParry, Laura
melbourne.contributor.authorSiebel, Andrew
dc.identifier.eissn1749-6632
melbourne.accessrightsThis item is currently not available from this repository


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