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dc.contributor.authorSiebel, AL
dc.contributor.authorGehring, HM
dc.contributor.authorParry, LJ
dc.date.available2017-10-04T01:07:39Z
dc.date.issued2004-04-01
dc.identifierpii: JNE1164
dc.identifier.citationSiebel, A. L., Gehring, H. M. & Parry, L. J. (2004). Steroid-independent regulation of uterine oxytocin receptors. JOURNAL OF NEUROENDOCRINOLOGY, 16 (4), pp.398-402. https://doi.org/10.1111/j.0953-8194.2004.01164.x.
dc.identifier.issn0953-8194
dc.identifier.urihttp://hdl.handle.net/11343/192572
dc.description.abstractThe oxytocin receptor is an important contractile-associated protein, up-regulated at term in the myometrium in many mammalian species. We conducted studies in a novel animal model to challenge the general view that gonadal steroids are a major regulatory factor of uterine oxytocin receptors. Female marsupials have separate uteri and, in monovular species such as the tammar wallaby, the conceptus is present in one uterus whereas the contralateral uterus is empty. A marked increase in myometrial oxytocin receptors occurs only in the gravid uterus. Fetectomy experiments demonstrated that local embryo-derived factors stimulate this gravid uterus-specific increase in oxytocin receptors, and that uterine distension is probably not a key component in this regulatory pathway. Unilateral ovariectomy has no significant effect on uterine oxytocin receptors, emphasizing the impact of the conceptus on oxytocin receptor regulation and the minimal influence of gonadal steroids on parturition in this species. Our data highlight that regulation of uterine oxytocin receptor expression is multifactorial, and does not necessarily rely on gonadal steroids.
dc.languageEnglish
dc.publisherWILEY
dc.titleSteroid-independent regulation of uterine oxytocin receptors
dc.typeJournal Article
dc.identifier.doi10.1111/j.0953-8194.2004.01164.x
melbourne.affiliation.departmentSchool of BioSciences
melbourne.affiliation.departmentZoology
melbourne.source.titleJOURNAL OF NEUROENDOCRINOLOGY
melbourne.source.volume16
melbourne.source.issue4
melbourne.source.pages398-402
melbourne.elementsid263140
melbourne.contributor.authorSIEBEL, ANDREW LLOYD
melbourne.contributor.authorGEHRING, HELEN MAREE
melbourne.contributor.authorParry, Laura
melbourne.contributor.authorSiebel, Andrew
dc.identifier.eissn1365-2826
melbourne.accessrightsThis item is currently not available from this repository


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