Medicine (Western Health) - Theses
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Role of circulating osteoprogenitors (COP) in musculoskeletal biology and function
Circulating osteoprogenitor (COP) cells have gained increasing prominence in musculoskeletal research. This thesis explores the role of COP cells in age-related diseases such as osteoporosis, sarcopenia and frailty. In the process, we developed a new flow cytometric methodology to quantify COP cells and lamin A, an important component of COP cells which showed a strong association with frailty and ageing. This diagnostic method offers a valid and potential tool to diagnose osteosarcopenia and predict frailty and disability in older adults.