Medicine (RMH) - Theses
Now showing items 1-10 of 164
Head control and infant plagiocephaly: towards prevention
The thesis investigated infant head control development for a new approach to prevention of deformational plagiocephaly associated with infants sleeping in supine (Back-to-Sleep) and reduced rates of Sudden Infant Death ...
Hereditary Haemorrhagic Telangiectasia: Genotype, phenotype and clinical practice
Hereditary Haemorrhagic Telangiectasia (HHT) is caused by pathogenic mutations in one of several genes, most commonly ENG, ACVRL1 or SMAD4. Characterised by dysregulated angiogenesis in multiple organs, it typically presents ...
Early intervention models of diabetes care to address adverse glycaemia in hospital
Diabetes affects one quarter of individuals in hospital and contributes to worse clinical and economic outcomes. Acute hyperglycaemia causes immune dysfunction, proinflammatory and prothrombotic changes, and endothelial ...
Advance care planning in rehabilitation settings
Advance care planning (ACP) is the process whereby patients are able to communicate with family and healthcare providers regarding future health care choices in the event that they do not have the capacity to do so. In ...
Non-pharmacological management of chronic pain in multiple sclerosis and rehabilitation outcomes
Multiple sclerosis (MS) is a chronic, inflammatory and demyelinating autoimmune condition which affects the central nervous system. Multiple sclerosis can present with a wide variety of symptoms and can affect a patient’s ...
Novel methods of symptom measurement in Parkinson's disease
Parkinsons Disease is a common neurodegenerative disorder characterized by bradykinesia, rigidity, gait impairment and rest tremor. Non-motor features including anosmia, Rapid eye movement sleep behavior disorder, autonomic ...
CD4+ T cell fate in multiple myeloma
The average age of onset of multiple myeloma (MM) is in the 7th decade coinciding with the development of immunosenescence. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies (most notably ...
Translational investigations of the intersection between Alzheimer’s disease and epilepsy: mechanistic insights and treatment opportunities
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive deficits compromising patients’ execution of daily activities. The incidence of unprovoked seizures has been reported to be ...
Cardiorespiratory and autonomic function in epilepsy: implications for clinical practice
Epilepsy is one of the most common serious neurological disorders in the world, affecting over 70 million people worldwide. It is associated with an increased risk of premature mortality as a direct or indirect consequence ...
Modelling Tuberculosis in Ethiopia: Spatiotemporal Transmission Dynamics and Effects of Public Health Interventions
Tuberculosis (TB) is now the world’s leading infectious killer with an estimated 10million cases and 1.6 million deaths in 2016. A small number of countries bear the majority of the burden of disease, with two-thirds of ...