Medicine (RMH) - Theses
Now showing items 1-10 of 168
Novel mechanisms of Atrial Fibrillation
This thesis has 3 distinct strands comprising of 5 separate studies, all of which evaluate novel mechanisms of atrial fibrillation (AF) in humans. The 3 strands include the impacts of sleep apnoea (OSA) (Chapters 2-4), ...
Manipulation of Natural Killer cells to improve stem cell transplant outcomes
Allogeneic haematopoietic stem cell transplantation (alloHSCT) is an effective and potentially curative treatment for many haematological malignancies due to its graft-versus-leukemia (GVL) effect. In order to achieve ...
Dissecting the cellular mechanisms of NMDA receptor antagonist-induced disruptions to working memory and gamma oscillations
Schizophrenia is a chronic, heterogeneous psychiatric disorder characterised by the experience of a suite of positive, negative and cognitive symptoms. Neural oscillations in the gamma frequency range (30-80 Hz) are ...
Investigating the immune landscape in gastric cancer
This thesis investigates the relationship between the immunological microenvironment and clinical outcomes of patients diagnosed with gastric cancer (GC). I conducted a comprehensive study integrating immune cellular and ...
Head control and infant plagiocephaly: towards prevention
The thesis investigated infant head control development for a new approach to prevention of deformational plagiocephaly associated with infants sleeping in supine (Back-to-Sleep) and reduced rates of Sudden Infant Death ...
Hereditary Haemorrhagic Telangiectasia: Genotype, phenotype and clinical practice
Hereditary Haemorrhagic Telangiectasia (HHT) is caused by pathogenic mutations in one of several genes, most commonly ENG, ACVRL1 or SMAD4. Characterised by dysregulated angiogenesis in multiple organs, it typically presents ...
Early intervention models of diabetes care to address adverse glycaemia in hospital
Diabetes affects one quarter of individuals in hospital and contributes to worse clinical and economic outcomes. Acute hyperglycaemia causes immune dysfunction, proinflammatory and prothrombotic changes, and endothelial ...
Advance care planning in rehabilitation settings
Advance care planning (ACP) is the process whereby patients are able to communicate with family and healthcare providers regarding future health care choices in the event that they do not have the capacity to do so. In ...
Non-pharmacological management of chronic pain in multiple sclerosis and rehabilitation outcomes
Multiple sclerosis (MS) is a chronic, inflammatory and demyelinating autoimmune condition which affects the central nervous system. Multiple sclerosis can present with a wide variety of symptoms and can affect a patient’s ...
Novel methods of symptom measurement in Parkinson's disease
Parkinsons Disease is a common neurodegenerative disorder characterized by bradykinesia, rigidity, gait impairment and rest tremor. Non-motor features including anosmia, Rapid eye movement sleep behavior disorder, autonomic ...