Medicine (RMH) - Theses
Now showing items 1-10 of 150
The effect of extracranial trauma and age on traumatic brain injury, and the role of neuroinflammation
Traumatic brain injury (TBI) is induced by external forces to the brain, and is a leading cause of mortality and morbidity worldwide. Although significant research efforts have been made to identify an effective treatment, ...
Using mathematical modelling to challenge accepted methods and paradigms of tuberculosis control and transmission
Tuberculosis (TB) represents a major public health issue at the global level. Despite the availability of vaccines and treatments, TB still kills around 1.6 million persons each year due to a combination of unresolved ...
High mobility group box protein 1 in paediatric traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity for children and young adults. Accumulating research suggests that children may be more vulnerable to poor long-term outcomes after TBI compared ...
Radiological, clinical and genetic markers of ischaemic stroke outcome
Acute ischaemic stroke is caused by a blocked blood vessel in the cerebral circulation. It is the most common form of stroke worldwide and a major cause of disability and death. Over the past 20 years, major advances in ...
Shear wave elastography in the assessment of liver fibrosis
The accurate quantification of liver fibrosis is essential to the prognostication and clinical management of patients with chronic liver disease (CLD). Whilst liver biopsy remains the gold standard for fibrosis assessment, ...
Improving application of human leukocyte antigen genotyping in precision medicine
Variation in the human leukocyte antigen (HLA) genes has been extensively associated with predisposition to autoimmune disease and adverse drug reaction. Translation of these associations to clinical practice has proven ...
Pain in Parkinson's disease
Pain is a common and disabling symptom in people with Parkinson's disease, but the pathophysiological mechanisms underlying this phenomenon remain poorly understood. Through the use of systematic review, meta-analysis ...
Understanding the relationship between obesity/ fat distribution/metabolic profiles and vitamin D status in young women (the safe-D study)
Vitamin D deficiency is highly prevalent and associated with an increased risk of many chronic health conditions including obesity, cardiovascular disease and diabetes. Vitamin D deficiency affects millions of Australians, ...
A customisable biosensor platform for point-of-care applications in precision medicine and immunodiagnostics
Point-of-care diagnostics play an indispensable role in clinical decision-making pathways as rapid and cost-effective alternatives or complementation to laboratory- based testing. The overarching aim of this thesis was to ...
Falling down the cascade: the gaps in care delivery for people living with chronic hepatitis B in Australia
In Australia, an estimated 239,000 people were living with chronic hepatitis B (CHB) in 2016. Most of the affected community were born overseas and acquired their infection early in life, in countries with high and ...