Traumatic brain injury (TBI) is induced by external forces to the brain, and is a leading cause of mortality and morbidity worldwide. Although significant research efforts have been made to identify an effective treatment, ...

Tuberculosis (TB) represents a major public health issue at the global level. Despite the availability of vaccines and treatments, TB still kills around 1.6 million persons each year due to a combination of unresolved ...

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity for children and young adults. Accumulating research suggests that children may be more vulnerable to poor long-term outcomes after TBI compared ...

Acute ischaemic stroke is caused by a blocked blood vessel in the cerebral circulation. It is the most common form of stroke worldwide and a major cause of disability and death. Over the past 20 years, major advances in ...

The accurate quantification of liver fibrosis is essential to the prognostication and clinical management of patients with chronic liver disease (CLD). Whilst liver biopsy remains the gold standard for fibrosis assessment, ...

Variation in the human leukocyte antigen (HLA) genes has been extensively associated with predisposition to autoimmune disease and adverse drug reaction. Translation of these associations to clinical practice has proven ...

Pain is a common and disabling symptom in people with Parkinson's disease, but the pathophysiological mechanisms underlying this phenomenon remain poorly understood. Through the use of systematic review, meta-analysis ...

Vitamin D deficiency is highly prevalent and associated with an increased risk of many chronic health conditions including obesity, cardiovascular disease and diabetes. Vitamin D deficiency affects millions of Australians, ...

Point-of-care diagnostics play an indispensable role in clinical decision-making pathways as rapid and cost-effective alternatives or complementation to laboratory- based testing. The overarching aim of this thesis was to ...

In Australia, an estimated 239,000 people were living with chronic hepatitis B (CHB) in 2016. Most of the affected community were born overseas and acquired their infection early in life, in countries with high and ...