Medicine (RMH) - Theses
Now showing items 1-10 of 146
Shear wave elastography in the assessment of liver fibrosis
The accurate quantification of liver fibrosis is essential to the prognostication and clinical management of patients with chronic liver disease (CLD). Whilst liver biopsy remains the gold standard for fibrosis assessment, ...
Improving application of human leukocyte antigen genotyping in precision medicine
Variation in the human leukocyte antigen (HLA) genes has been extensively associated with predisposition to autoimmune disease and adverse drug reaction. Translation of these associations to clinical practice has proven ...
Pain in Parkinson's disease
Pain is a common and disabling symptom in people with Parkinson's disease, but the pathophysiological mechanisms underlying this phenomenon remain poorly understood. Through the use of systematic review, meta-analysis ...
Understanding the relationship between obesity/ fat distribution/metabolic profiles and vitamin D status in young women (the safe-D study)
Vitamin D deficiency is highly prevalent and associated with an increased risk of many chronic health conditions including obesity, cardiovascular disease and diabetes. Vitamin D deficiency affects millions of Australians, ...
A customisable biosensor platform for point-of-care applications in precision medicine and immunodiagnostics
Point-of-care diagnostics play an indispensable role in clinical decision-making pathways as rapid and cost-effective alternatives or complementation to laboratory- based testing. The overarching aim of this thesis was to ...
Falling down the cascade: the gaps in care delivery for people living with chronic hepatitis B in Australia
In Australia, an estimated 239,000 people were living with chronic hepatitis B (CHB) in 2016. Most of the affected community were born overseas and acquired their infection early in life, in countries with high and ...
Pre-clinical applications of endobronchial ultrasound in lung cancer
The last decade has seen a paradigm shift in the clinical approach to lung cancer. Treatment has evolved from empirical to rational, based on molecular profiling of tissue obtained by minimally invasive techniques such as ...
Antiepileptic drug teratogenicity: a human and laboratory translational study
Antiepileptic drug (AED) associated teratogenicity has been well documented in the literature. The risk of physical birth defects during the first trimester of pregnancy is increased threefold for most AEDs and over ten-fold ...
Gamma oscillations in animal models of schizophrenia
Schizophrenia is a complex neuropsychiatric disorder most prominently characterised by psychotic symptoms as well as a multitude of sensory and cognitive disturbances. Recent heuristic models of schizophrenia propose that ...
The neuropsychiatric disorders of focal epilepsy
Neuropsychiatric disorders commonly co-exist with focal epilepsy. Despite intense investigation there remains significant limitations to our current understanding of the aetiological relationship between these conditions, ...