Post-operative seizures are common in patients with supratentorial diffuse gliomas. Pharmacoresistant seizures occur in up to one third of patients in the post-operative period and for many patients, particularly those ...

Glioblastoma (GBM) is the most common, and the most aggressive, adult brain tumour, affecting over one thousand Australians per year. It carries a high mortality burden and a high social burden to both the cancer sufferer ...

Prion diseases comprise a group of rare neurodegenerative disorders that affect both humans and animals. Regardless of the host species, misfolding of normal prion protein (PrPC) into abnormal conformers (PrPSc) with the ...

Cognitive deficits in schizophrenia represent the most disabling symptom category of the disorder for which there is currently a lack of consistently effective treatment. This may be attributable to our limited understanding ...

Plasmodium falciparum is the most deadly Plasmodium species that infects humans and causes malaria, a life-threatening parasitic disease. The cyclical expression of the majority of its genes is tightly regulated during its ...

Intracerebral haemorrhage (ICH) results from rupture of an intracranial blood vessel and contributes to 10-15% of all strokes. Despite being a relatively uncommon presentation of stroke it contributes to 50% mortality and ...

This body of work comprises contributions to human cerebrovascular disease as performed over a period of 12 years (from year 2005 to 2017) as a specialist at major university teaching hospital in Melbourne in collaboration ...

Introduction Epilepsy is a common neurologic disease. Acquired epilepsy is caused by a brain insult (e.g., brain trauma or excitotoxicity); however, there is a latent period from several months-to-years between the insult ...

Epilepsy is one of the most common neurological disorders, affecting people of all ages, races, social classes, and nationalities. It is characterised by an enduring predisposition to generate epileptic seizures, and by ...

Antiepileptic drugs (AEDs) remain the mainstay of intervention or treatment of epileptic seizures. There is still a lack of understanding about mechanisms of clinical AEDs. As seizures are an intrinsically network phenomenon, ...