Medicine (RMH) - Theses
Now showing items 1-10 of 159
Novel methods of symptom measurement in Parkinson's disease
Parkinsons Disease is a common neurodegenerative disorder characterized by bradykinesia, rigidity, gait impairment and rest tremor. Non-motor features including anosmia, Rapid eye movement sleep behavior disorder, autonomic ...
CD4+ T cell fate in multiple myeloma
The average age of onset of multiple myeloma (MM) is in the 7th decade coinciding with the development of immunosenescence. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies (most notably ...
Translational investigations of the intersection between Alzheimer’s disease and epilepsy: mechanistic insights and treatment opportunities
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive cognitive deficits compromising patients’ execution of daily activities. The incidence of unprovoked seizures has been reported to be ...
Cardiorespiratory and autonomic function in epilepsy: implications for clinical practice
Epilepsy is one of the most common serious neurological disorders in the world, affecting over 70 million people worldwide. It is associated with an increased risk of premature mortality as a direct or indirect consequence ...
Modelling Tuberculosis in Ethiopia: Spatiotemporal Transmission Dynamics and Effects of Public Health Interventions
Tuberculosis (TB) is now the world’s leading infectious killer with an estimated 10million cases and 1.6 million deaths in 2016. A small number of countries bear the majority of the burden of disease, with two-thirds of ...
A multi-faceted approach to atrial fibrillation: from lifestyle factors to invasive therapies
Atrial fibrillation (AF) is a leading epidemic of cardiovascular disease in developed countries, owing to an ageing population and the Western lifestyle. In addition to effects on quality of life and economic burden on the ...
Characterizing functional antibody responses in malaria in pregnancy
Malaria is a major threat to the tropical regions around the world. The World Health Organization has reported Plasmodium falciparum as the most lethal malaria parasite species. It is also reported that a huge proportion ...
Antibody immunity to Plasmodium falciparum erythrocyte membrane protein 1 and severe malaria
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of the infected erythrocyte (IE). These proteins mediate the adhesion of the parasite IE to host cells which could result ...
Palliative care for patients with chronic obstructive pulmonary disease: understanding current practices and exploring a new model of integrated care
Chronic obstructive pulmonary disease (COPD) is a highly prevalent, incurable, progressive, disease characterised by persisting respiratory symptoms and airflow limitation, which arise from airway or parenchymal abnormalities. ...
The effect of extracranial trauma and age on traumatic brain injury, and the role of neuroinflammation
Traumatic brain injury (TBI) is induced by external forces to the brain, and is a leading cause of mortality and morbidity worldwide. Although significant research efforts have been made to identify an effective treatment, ...