The accurate quantification of liver fibrosis is essential to the prognostication and clinical management of patients with chronic liver disease (CLD). Whilst liver biopsy remains the gold standard for fibrosis assessment, ...

Variation in the human leukocyte antigen (HLA) genes has been extensively associated with predisposition to autoimmune disease and adverse drug reaction. Translation of these associations to clinical practice has proven ...

Pain is a common and disabling symptom in people with Parkinson's disease, but the pathophysiological mechanisms underlying this phenomenon remain poorly understood. Through the use of systematic review, meta-analysis ...

Vitamin D deficiency is highly prevalent and associated with an increased risk of many chronic health conditions including obesity, cardiovascular disease and diabetes. Vitamin D deficiency affects millions of Australians, ...

Point-of-care diagnostics play an indispensable role in clinical decision-making pathways as rapid and cost-effective alternatives or complementation to laboratory- based testing. The overarching aim of this thesis was to ...

In Australia, an estimated 239,000 people were living with chronic hepatitis B (CHB) in 2016. Most of the affected community were born overseas and acquired their infection early in life, in countries with high and ...

The last decade has seen a paradigm shift in the clinical approach to lung cancer. Treatment has evolved from empirical to rational, based on molecular profiling of tissue obtained by minimally invasive techniques such as ...

Antiepileptic drug (AED) associated teratogenicity has been well documented in the literature. The risk of physical birth defects during the first trimester of pregnancy is increased threefold for most AEDs and over ten-fold ...

Schizophrenia is a complex neuropsychiatric disorder most prominently characterised by psychotic symptoms as well as a multitude of sensory and cognitive disturbances. Recent heuristic models of schizophrenia propose that ...

Neuropsychiatric disorders commonly co-exist with focal epilepsy. Despite intense investigation there remains significant limitations to our current understanding of the aetiological relationship between these conditions, ...