This thesis has 3 distinct strands comprising of 5 separate studies, all of which evaluate novel mechanisms of atrial fibrillation (AF) in humans. The 3 strands include the impacts of sleep apnoea (OSA) (Chapters 2-4), ...

Allogeneic haematopoietic stem cell transplantation (alloHSCT) is an effective and potentially curative treatment for many haematological malignancies due to its graft-versus-leukemia (GVL) effect. In order to achieve ...

Schizophrenia is a chronic, heterogeneous psychiatric disorder characterised by the experience of a suite of positive, negative and cognitive symptoms. Neural oscillations in the gamma frequency range (30-80 Hz) are ...

This thesis investigates the relationship between the immunological microenvironment and clinical outcomes of patients diagnosed with gastric cancer (GC). I conducted a comprehensive study integrating immune cellular and ...

The thesis investigated infant head control development for a new approach to prevention of deformational plagiocephaly associated with infants sleeping in supine (Back-to-Sleep) and reduced rates of Sudden Infant Death ...

Hereditary Haemorrhagic Telangiectasia (HHT) is caused by pathogenic mutations in one of several genes, most commonly ENG, ACVRL1 or SMAD4. Characterised by dysregulated angiogenesis in multiple organs, it typically presents ...

Diabetes affects one quarter of individuals in hospital and contributes to worse clinical and economic outcomes. Acute hyperglycaemia causes immune dysfunction, proinflammatory and prothrombotic changes, and endothelial ...

Advance care planning (ACP) is the process whereby patients are able to communicate with family and healthcare providers regarding future health care choices in the event that they do not have the capacity to do so. In ...

Multiple sclerosis (MS) is a chronic, inflammatory and demyelinating autoimmune condition which affects the central nervous system. Multiple sclerosis can present with a wide variety of symptoms and can affect a patient’s ...

Parkinsons Disease is a common neurodegenerative disorder characterized by bradykinesia, rigidity, gait impairment and rest tremor. Non-motor features including anosmia, Rapid eye movement sleep behavior disorder, autonomic ...