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DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association (NATURE RESEARCH, 2021-02-03)Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with ...
Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer (SPRINGERNATURE, 2018-07-20)Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic islet cells. Here we report the analysis of gene mutation, copy number, and RNA expression of 57 sporadic well-differentiated pNETs. ...
Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer (BMJ PUBLISHING GROUP, 2018-12-01)OBJECTIVE: Extensive molecular heterogeneity of pancreatic ductal adenocarcinoma (PDA), few effective therapies and high mortality make this disease a prime model for advancing development of tailored therapies. The ...