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dc.contributor.authorPedrini, S
dc.contributor.authorGupta, VB
dc.contributor.authorHone, E
dc.contributor.authorDoecke, J
dc.contributor.authorO'Bryant, S
dc.contributor.authorJames, I
dc.contributor.authorBush, AI
dc.contributor.authorRowe, CC
dc.contributor.authorVillemagne, VL
dc.contributor.authorAmes, D
dc.contributor.authorMasters, CL
dc.contributor.authorMartins, RN
dc.date.available2017-12-14T02:57:14Z
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.available2017-09-25
dc.date.issued2017-10-25
dc.identifierpii: 10.1038/s41598-017-14020-9
dc.identifier.citationPedrini, S., Gupta, V. B., Hone, E., Doecke, J., O'Bryant, S., James, I., Bush, A. I., Rowe, C. C., Villemagne, V. L., Ames, D., Masters, C. L. & Martins, R. N. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. SCIENTIFIC REPORTS, 7 (1), https://doi.org/10.1038/s41598-017-14020-9.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11343/194899
dc.description.abstractAlzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid deposition in HC, suggesting that these two biomarkers might be used to detect at risk individuals. Additionally, other biomarkers (Eotaxin-3, Leptin, PYY) exhibited altered levels in AD participants possessing the APOE ε4 allele. This suggests that the physiology of some potential biomarkers may be altered in AD due to the APOE ε4 allele, a major risk factor for AD. Taken together, these data highlight several potential biomarkers that can be used in a blood-based panel to allow earlier identification of individuals at risk of developing AD and/or early stage AD for which current therapies may be more beneficial.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleA blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort
dc.typeJournal Article
dc.identifier.doi10.1038/s41598-017-14020-9
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMelbourne Medical School
melbourne.affiliation.departmentAustin Academic Centre
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.departmentEastern Hill Academic Centre
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.departmentSurgery (St Vincent's)
melbourne.affiliation.departmentMedicine (RMH Academic Centre)
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentMelbourne School of Psychological Sciences
melbourne.affiliation.departmentSchool of Biomedical Sciences
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.source.titleSCIENTIFIC REPORTS
melbourne.source.volume7
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1271201
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656630
melbourne.contributor.authorAmes, David
melbourne.contributor.authorBush, Ashley
melbourne.contributor.authorVillemagne, Victor
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorRowe, Christopher
melbourne.contributor.authorNigro, Julie
melbourne.contributor.authorHorne, Malcolm
melbourne.contributor.authorYates, Paul
dc.identifier.eissn2045-2322
pubs.acceptance.date2017-09-25
melbourne.accessrightsOpen Access


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