Centre for Eye Research Australia (CERA)

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The impact of diabetic retinopathy on quality of life: qualitative findings from an item bank development project

Fenwick, EK; Pesudovs, K; Khadka, J; Dirani, M; Rees, G; Wong, TY; Lamoureux, EL (SPRINGER, 2012-12-01)

PURPOSE: Assessing the efficacy of treatment modalities for diabetic retinopathy (DR) from the patient's perspective is restricted due to a lack of a comprehensive patient-reported outcome measure. We are developing a ...

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

Sanchez, MIGL; Waugh, HS; Tsatsanis, A; Wong, BX; Crowston, JG; Duce, JA; Trounce, IA (NATURE PUBLISHING GROUP, 2017-08-29)

Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer's disease are associated with mutations ...

The Prevalence of Self-Reported Diabetes in the Australian National Eye Health Survey

Keel, S; Foreman, J; Xie, J; van Wijngaarden, P; Taylor, HR; Dirani, M (PUBLIC LIBRARY SCIENCE, 2017-01-03)

OBJECTIVE: To present the prevalence of self-reported diabetes in Indigenous and non-Indigenous participants in the National Eye Health Survey. RESEARCH DESIGN AND METHODS: 3098 non-Indigenous Australians aged 50-98 years ...

Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati

Cama, A; Muller, A; Taoaba, R; Butchers, RMR; Itibita, L; Migchelsen, SJ; Kiauea, T; Pickering, H; Willis, R; Roberts, CH; ... (PUBLIC LIBRARY SCIENCE, 2017-09-01)

OBJECTIVE: In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most ...

Six-year changes in refraction and related ocular biometric factors in an adult Chinese population

Han, X; Guo, X; Lee, PY; Morgan, IG; He, M (PUBLIC LIBRARY SCIENCE, 2017-08-30)

PURPOSE: To investigate longitudinal changes in refraction and biometry in Chinese adults. DESIGN: Population-based prospective cohort study. METHODS: 1817 subjects aged ≥ 35 years were randomly recruited from Yuexiu ...

Transforming Growth Factor beta 1-Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Brown, KD; Shah, MH; Liu, G-S; Chan, EC; Crowston, JG; Peshavariya, HM (ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017-06-01)

Purpose: Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic ...

Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

Hung, SSC; Van Bergen, NJ; Jackson, S; Liang, H; Mackey, DA; Hernandez, D; Lim, SY; Hewitt, AW; Trounce, I; Pebay, A; ... (IMPACT JOURNALS LLC, 2016-05-01)

Reprogramming of somatic cells into a pluripotent state is known to be accompanied by extensive restructuring of mitochondria and switch in metabolic requirements. Here we utilized Leber's hereditary optic neuropathy (LHON) ...

Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

Lidgerwood, GE; Lim, SY; Crombie, DE; Ali, R; Gill, KP; Hernandez, D; Kie, J; Conquest, A; Waugh, HS; Wong, RCB; ... (HUMANA PRESS INC, 2016-04-01)

We demonstrate that a combination of Noggin, Dickkopf-1, Insulin Growth Factor 1 and basic Fibroblast Growth Factor, promotes the differentiation of human pluripotent stem cells into retinal pigment epithelium (RPE) cells. ...

The validity of self-report of eye diseases in participants with vision loss in the National Eye Health Survey

Foreman, J; Xie, J; Keel, S; van Wijngaarden, P; Taylor, HR; Dirani, M (NATURE PUBLISHING GROUP, 2017-08-18)

We assessed the validity and reliability of self-report of eye disease in participants with unilateral vision loss (presenting visual acuity worse than 6/12 in the worse eye and equal to or better than 6/12 in the better ...

Generation of a human induced pluripotent stem cell line CERAi001-A-6 using episomal vectors

Wong, RCB; Hung, SS; Jackson, S; Singh, V; Khan, S; Liang, HH; Kearns, LS; Nguyena, T; Conquest, A; Daniszewski, M; ... (ELSEVIER SCIENCE BV, 2017-07-01)

We report the generation of the hiPSC line CERAi001-A-6 from primary human dermal fibroblasts. Reprogramming was performed using episomal vector delivery of OCT4, SOX2, KLF4, L-MYC, LIN28 and shRNA for p53.