Centre for Eye Research Australia (CERA)

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Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study

Cuellar-Partida, G; Williams, KM; Yazar, S; Guggenheim, JA; Hewitt, AW; Williams, C; Wang, JJ; Kho, P-F; Saw, SM; Cheng, C-Y; ... (OXFORD UNIV PRESS, 2017-12-01)

Background: Myopia prevalence has increased in the past 20 years, with many studies linking the increase to reduced time spent outdoors. A number of recent observational studies have shown an inverse association between ...

The impact of diabetic retinopathy on quality of life: qualitative findings from an item bank development project

Fenwick, EK; Pesudovs, K; Khadka, J; Dirani, M; Rees, G; Wong, TY; Lamoureux, EL (SPRINGER, 2012-12-01)

PURPOSE: Assessing the efficacy of treatment modalities for diabetic retinopathy (DR) from the patient's perspective is restricted due to a lack of a comprehensive patient-reported outcome measure. We are developing a ...

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

Sanchez, MIGL; Waugh, HS; Tsatsanis, A; Wong, BX; Crowston, JG; Duce, JA; Trounce, IA (NATURE PUBLISHING GROUP, 2017-08-29)

Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer's disease are associated with mutations ...

Retinal Changes in an ATP-Induced Model of Retinal Degeneration

Aplin, FP; Vessey, KA; Luu, CD; Guymer, RH; Shepherd, RK; Fletcher, EL (FRONTIERS MEDIA SA, 2016-04-29)

In rodents and felines, intravitreal administration of adenosine triphosphate (ATP) has been shown to induce photoreceptor death providing a tractable model of retinal degeneration in these species. This study investigated ...

The Prevalence of Self-Reported Diabetes in the Australian National Eye Health Survey

Keel, S; Foreman, J; Xie, J; van Wijngaarden, P; Taylor, HR; Dirani, M (PUBLIC LIBRARY SCIENCE, 2017-01-03)

OBJECTIVE: To present the prevalence of self-reported diabetes in Indigenous and non-Indigenous participants in the National Eye Health Survey. RESEARCH DESIGN AND METHODS: 3098 non-Indigenous Australians aged 50-98 years ...

Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati

Cama, A; Muller, A; Taoaba, R; Butchers, RMR; Itibita, L; Migchelsen, SJ; Kiauea, T; Pickering, H; Willis, R; Roberts, CH; ... (PUBLIC LIBRARY SCIENCE, 2017-09-01)

OBJECTIVE: In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most ...

Six-year changes in refraction and related ocular biometric factors in an adult Chinese population

Han, X; Guo, X; Lee, PY; Morgan, IG; He, M (PUBLIC LIBRARY SCIENCE, 2017-08-30)

PURPOSE: To investigate longitudinal changes in refraction and biometry in Chinese adults. DESIGN: Population-based prospective cohort study. METHODS: 1817 subjects aged ≥ 35 years were randomly recruited from Yuexiu ...

Enriched retinal ganglion cells derived from human embryonic stem cells

Gill, KP; Hung, SSC; Sharov, A; Lo, CY; Needham, K; Lidgerwood, GE; Jackson, S; Crombie, DE; Nayagam, BA; Cook, AL; ... (NATURE PUBLISHING GROUP, 2016-08-10)

Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to vision impairment. Development of cell therapy requires a better understanding of the signals that direct stem cells into RGCs. ...

Transforming Growth Factor beta 1-Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts

Brown, KD; Shah, MH; Liu, G-S; Chan, EC; Crowston, JG; Peshavariya, HM (ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017-06-01)

Purpose: Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic ...

Quantitative Analysis of the Ellipsoid Zone Intensity in Phenotypic Variations of Intermediate Age-Related Macular Degeneration

Gin, TJ; Wu, Z; Chew, SKH; Guymer, RH; Luu, CD (ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017-04-01)

Purpose: Reduction of the ellipsoid zone (EZ) intensity has been reported in eyes with age-related macular degeneration (AMD). This study determined whether overall EZ intensity, in retinal locations undisturbed by pathologic ...