Centre for Eye Research Australia (CERA) - Research Publications
Now showing items 1-10 of 24
The impact of diabetic retinopathy on quality of life: qualitative findings from an item bank development project
PURPOSE: Assessing the efficacy of treatment modalities for diabetic retinopathy (DR) from the patient's perspective is restricted due to a lack of a comprehensive patient-reported outcome measure. We are developing a ...
The Prevalence of Self-Reported Diabetes in the Australian National Eye Health Survey
(PUBLIC LIBRARY SCIENCE, 2017-01-03)
OBJECTIVE: To present the prevalence of self-reported diabetes in Indigenous and non-Indigenous participants in the National Eye Health Survey. RESEARCH DESIGN AND METHODS: 3098 non-Indigenous Australians aged 50-98 years ...
Prevalence of signs of trachoma, ocular Chlamydia trachomatis infection and antibodies to Pgp3 in residents of Kiritimati Island, Kiribati
(PUBLIC LIBRARY SCIENCE, 2017-09-01)
OBJECTIVE: In some Pacific Island countries, such as Solomon Islands and Fiji, active trachoma is common, but ocular Chlamydia trachomatis (Ct) infection and trachomatous trichiasis (TT) are rare. On Tarawa, the most ...
Transforming Growth Factor beta 1-Induced NADPH Oxidase-4 Expression and Fibrotic Response in Conjunctival Fibroblasts
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017-06-01)
Purpose: Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic ...
The validity of self-report of eye diseases in participants with vision loss in the National Eye Health Survey
(NATURE PUBLISHING GROUP, 2017-08-18)
We assessed the validity and reliability of self-report of eye disease in participants with unilateral vision loss (presenting visual acuity worse than 6/12 in the worse eye and equal to or better than 6/12 in the better ...
Altered biometal homeostasis is associated with CLN6 mRNA loss in mouse neuronal ceroid lipofuscinosis
(COMPANY OF BIOLOGISTS LTD, 2013-06-15)
Neuronal ceroid lipofuscinoses, the most common fatal childhood neurodegenerative illnesses, share many features with more prevalent neurodegenerative diseases. Neuronal ceroid lipofuscinoses are caused by mutations in CLN ...
Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy
(IMPACT JOURNALS LLC, 2017-04-01)
Cybrid technology was used to replace Leber hereditary optic neuropathy (LHON) causing mitochondrial DNA (mtDNA) mutations from patient-specific fibroblasts with wildtype mtDNA, and mutation-free induced pluripotent stem ...
Emerging ocular biomarkers of Alzheimer disease
Interest in reliable biomarkers of Alzheimer disease, the leading cause of dementia, has been fuelled by challenges in diagnosing the disease and monitoring disease progression as well as the response to therapy. A range ...
Enriched retinal ganglion cells derived from human embryonic stem cells
(NATURE PUBLISHING GROUP, 2016-08-10)
Optic neuropathies are characterised by a loss of retinal ganglion cells (RGCs) that lead to vision impairment. Development of cell therapy requires a better understanding of the signals that direct stem cells into RGCs. ...
Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta
(NATURE PUBLISHING GROUP, 2017-08-29)
Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer's disease are associated with mutations ...