Medicine and Radiology - Research Publications
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Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health
(SPRINGER, 2016-06-01)
Long-term anti-epileptic drug (AED) therapy is associated with increased fracture risk. This study tested whether substituting the newer AED levetiracetam has less adverse effects on bone than older AEDs. An open-label ...
The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells
(NATURE PUBLISHING GROUP, 2016-01-01)
Interleukin (IL)-10-producing B cells (B10 cells) have emerged as important regulatory elements with immunosuppressive roles. Chronic lymphocytic leukemia (CLL) B cells also secrete IL-10 and share features of B10 cells, ...
Technologies for Advanced Gait and Balance Assessments in People with Multiple Sclerosis
(FRONTIERS MEDIA SA, 2018-02-02)
Subtle gait and balance dysfunction is a precursor to loss of mobility in multiple sclerosis (MS). Biomechanical assessments using advanced gait and balance analysis technologies can identify these subtle changes and could ...
Tremor in multiple sclerosis is associated with cerebello-thalamic pathology
(SPRINGER WIEN, 2017-12-01)
Tremor in people with multiple sclerosis (MS) is a frequent and debilitating symptom with a relatively poorly understood pathophysiology. To determine the relationship between clinical tremor severity and structural magnetic ...
Feasibility of identifying the ideal locations for motor intention decoding using unimodal and multimodal classification at 7T-fMRI
(NATURE PUBLISHING GROUP, 2018-10-22)
Invasive Brain-Computer Interfaces (BCIs) require surgeries with high health-risks. The risk-to-benefit ratio of the procedure could potentially be improved by pre-surgically identifying the ideal locations for mental ...
Bone loss with antiepileptic drug therapy: a twin and sibling study
(SPRINGER LONDON LTD, 2017-09-01)
Changes in areal bone mineral density (aBMD) and other predictors of bone loss were evaluated in 48 same-sex twin/age-matched sibling pairs discordant for antiepileptic drug (AED) use. AED users had reduced BMD at the hip ...
Circulating T-FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity
(AMER ASSOC ADVANCEMENT SCIENCE, 2018-02-14)
Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy to combat seasonal influenza infections. IIV activates B cells and T follicular helper (TFH) cells and thus engenders ...
Biomarkers for Macrosomia Prediction in Pregnancies Affected by Diabetes
(FRONTIERS MEDIA SA, 2018-07-31)
Large birthweight, or macrosomia, is one of the commonest complications for pregnancies affected by diabetes. As macrosomia is associated with an increased risk of a number of adverse outcomes for both the mother and ...
Short- and Long-Term Efficacy of Modafinil at Improving Quality of Life in Stroke Survivors: A Post Hoc Sub Study of the Modafinil in Debilitating Fatigue After Stroke Trial
(FRONTIERS MEDIA SA, 2018-04-25)
Background: The phase-II modafinil in debilitating fatigue after stroke trial demonstrated that modafinil improves fatigue and quality of life in severely fatigued stroke survivors. For this study, we sought to examine the ...
The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites
(PUBLIC LIBRARY SCIENCE, 2017-07-21)
Malaria is caused by five different Plasmodium spp. in humans each of which modifies the host erythrocyte to survive and replicate. The two main causes of malaria, P. falciparum and P. vivax, differ in their ability to ...
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