Medicine and Radiology - Research Publications
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Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health
(SPRINGER, 2016-06-01)
Long-term anti-epileptic drug (AED) therapy is associated with increased fracture risk. This study tested whether substituting the newer AED levetiracetam has less adverse effects on bone than older AEDs. An open-label ...
The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells
(NATURE PUBLISHING GROUP, 2016-01-01)
Interleukin (IL)-10-producing B cells (B10 cells) have emerged as important regulatory elements with immunosuppressive roles. Chronic lymphocytic leukemia (CLL) B cells also secrete IL-10 and share features of B10 cells, ...
Technologies for Advanced Gait and Balance Assessments in People with Multiple Sclerosis
(FRONTIERS MEDIA SA, 2018-02-02)
Subtle gait and balance dysfunction is a precursor to loss of mobility in multiple sclerosis (MS). Biomechanical assessments using advanced gait and balance analysis technologies can identify these subtle changes and could ...
Tremor in multiple sclerosis is associated with cerebello-thalamic pathology
(SPRINGER WIEN, 2017-12-01)
Tremor in people with multiple sclerosis (MS) is a frequent and debilitating symptom with a relatively poorly understood pathophysiology. To determine the relationship between clinical tremor severity and structural magnetic ...
Feasibility of identifying the ideal locations for motor intention decoding using unimodal and multimodal classification at 7T-fMRI
(NATURE PUBLISHING GROUP, 2018-10-22)
Invasive Brain-Computer Interfaces (BCIs) require surgeries with high health-risks. The risk-to-benefit ratio of the procedure could potentially be improved by pre-surgically identifying the ideal locations for mental ...
Biomarkers for Macrosomia Prediction in Pregnancies Affected by Diabetes
(FRONTIERS MEDIA SA, 2018-07-31)
Large birthweight, or macrosomia, is one of the commonest complications for pregnancies affected by diabetes. As macrosomia is associated with an increased risk of a number of adverse outcomes for both the mother and ...
Short- and Long-Term Efficacy of Modafinil at Improving Quality of Life in Stroke Survivors: A Post Hoc Sub Study of the Modafinil in Debilitating Fatigue After Stroke Trial
(FRONTIERS MEDIA SA, 2018-04-25)
Background: The phase-II modafinil in debilitating fatigue after stroke trial demonstrated that modafinil improves fatigue and quality of life in severely fatigued stroke survivors. For this study, we sought to examine the ...
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
(NATURE PUBLISHING GROUP, 2019-05-28)
Telomerase negative immortal cancer cells elongate telomeres through the Alternative Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is required to maintain ALT, it might also lead to ...
Low T-Cell Responses to Mitogen Stimulation Predicts Poor Survival in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
(FRONTIERS MEDIA SA, 2017-11-09)
Background: Successful engraftment and reconstitution of the innate and adaptive immune system are associated with improved outcomes in recipients of allogeneic hematopoietic stem cell transplantation (HSCT). A clinically ...
Development of an Ultrasensitive Impedimetric Immunosensor Platform for Detection of Plasmodium Lactate Dehydrogenase
(MDPI, 2019-06-01)
Elimination of malaria is a global health priority. Detecting an asymptomatic carrier of Plasmodium parasites to receive treatment is an important step in achieving this goal. Current available tools for detection of malaria ...
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