Trial registration and abstracts from the American Society of Anesthesiologists meetings 2010-2013: a retrospective observational study of methods
AuthorChong, Simon; Peyton, Philip; Imberger, Georgina; Simons, Koen; Bianco, Anthony; Liskaser, Grace; Burggraf, Millicent
AffiliationMedicine (Western Health)
Access StatusOpen Access
This project is part of a Doctor of Medical Science research higher degree.
There are three main parts to this project, of which this is part three.
Part Three will involve a systematic search for trial registration of all randomised controlled trial abstracts presented at the ASA Annual Meetings 2010-2013. This will involve searches of the clinicaltrials.gov website (United States Trial Registry website), the International Standard Randomised Controlled Trial Number Register (ISRCTN), and the World Health Organization International Clinical Trials Registry Platform. The primary endpoint will be a comparison between the proportion of positive outcome trials which did not have prospective registration versus the proportion of positive outcome trials with prospective registration. We define a 20% reduction in positive outcomes as clinically significant when comparing trials without prospective registration to trials with prospective registration. We will also calculate the proportion of trials prospectively registered, that displayed a major discrepancy between their trial registration entry and their published paper.
Keywordsprotocol; publication bias; anaesthesia; trial registration; selective outcome reporting
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