Paediatrics (RCH) - Theses
Now showing items 1-10 of 226
Subjective and objective sleep outcomes in young adults who sustained traumatic brain injury in childhood: relationship with fatigue, depression, and quality of life
Background: Traumatic Brain Injury (TBI) is highly prevalent in children and often associated with impairments in several functional domains including sleep. Sleep-wake disturbances (SWD) are common in children with TBI ...
Prevalence, risk factors and outcomes of hearing loss in Australian children and adults: growing up in Australia’s child health CheckPoint study
Background Hearing loss of ageing is being reframed as a lifecourse problem with childhood origins. Supporting this theory, recent studies suggest a possible role of obesity, inflammation and telomere shortening in the ...
Intragenic DNA methylation and neurodevelopmental outcomes in children with fragile X-related disorders
The type and severity of clinical involvement in children with fragile X syndrome (FXS) and disorders related to premutations (PM) of the fragile X mental retardation 1 gene (FMR1), herein collectively denoted as fragile ...
Vaccinating against Helicobacter pylori-induced gastritis
Infections caused by stomach dwelling bacteria Helicobacter pylori which infect half of the World's population are the main cause of gastric pathologies including peptic ulcers and gastric adenocarcinoma, the latter being ...
Statistical modelling of lung function from multiple-breath washout and complex tidal flow waveform data
Multiple-breath washout (MBW) and tidal flow waveform data, widely used to measure lung function in paediatric settings, are typically analysed using simple empirical summaries rather than statistical models. Yet the data ...
Clowns in the midst: understanding clown doctors at The Royal Children's Hospital Melbourne
Clown doctors are a feature in paediatric hospitals, visiting children and families, providing a welcome escape from the reality of hospitalisation. Though the use of humour to improve health and wellbeing has been widely ...
Determining the genetic basis of mitochondrial complex I deficiency in children using massively parallel sequencing
Mitochondrial oxidative phosphorylation (OXPHOS) disorders constitute the largest group of inborn errors of metabolism. Complex I (CI) deficiency is the most common enzymatic defect identified within mitochondrial OXPHOS ...
Proximal femoral osteotomy in children and adolescents with cerebral palsy
Background Cerebral Palsy (CP) is the most common cause of physical disability affecting children in developed countries. Approximately one third of children with CP may develop hip displacement. Non-ambulant children at ...
Determinants and outcomes of dietary trajectories and obesity measures in children/adolescents and their parents: the longitudinal study of Australian children
Aims: The aims of this thesis were to investigate the (1) extent to which dietary scores and patterns remain stable from 2-3 to 10-11, and from 4-5 to 14-15, years of age; (2) determinants of this stability or change, ...
Improving oxygen therapy for children and newborns in Nigerian hospitals
Oxygen is a long-established medical therapy that can be life-saving for severely ill children admitted to hospital. Effective provision of oxygen to patients requires a multifaceted system that involves technical, clinical, ...