Background: The Fontan procedure was developed approximately 50 years ago and has become the definitive treatment for children born with single ventricle physiology. Surgical refinement of the Fontan technique and ...

Anaphylaxis is a severe allergic reaction that is rapid in onset and may cause death. There are increasing reports from individual countries and regions on anaphylaxis prevalence or incidence; however, there has been no ...

The introduction of the strategy of staged surgical palliation, with the Fontan operation as the final stage, has enabled the survival of almost five generations of children born with congenital heart defects that result ...

One third of the worlds’ population have evidence of hepatitis B infection making it one of the most important global health problems of this century. The risk of developing chronic hepatitis B is greatest if acquired as ...

Cystic Fibrosis (CF) is an autosomal recessive condition caused by a mutation in the cystic fibrosis transmembrane regulator (CFTR) gene. It is commonly known as a disease affecting the lungs. Advances in screening, diagnosis ...

Anorexia Nervosa (AN) is the eating disorder characterised by emaciation and underweight, commonly precipitated by dietary restriction that progresses to increasing restriction and self-starvation. AN predominantly develops ...

While the genes underlying the genetic brittle bone disease, osteogenesis imperfecta (OI), are well established, the precise pathological mechanisms are unclear. Recent studies have suggested that ER-stress resulting from ...

Extracorporeal membrane oxygenation (ECMO) is a modified form of heart-lung machine that aims to provide short- to-medium length of support to patients with cardiac and/or respiratory dysfunction. Children represent the ...

Epidemiological and genetic studies on food allergy to date have focused primarily on the Caucasian population. This is despite emerging evidence that food allergy appears to be rising in Asian countries, alongside the ...

Background: Traumatic Brain Injury (TBI) is highly prevalent in children and often associated with impairments in several functional domains including sleep. Sleep-wake disturbances (SWD) are common in children with TBI ...