Background: Traumatic Brain Injury (TBI) is highly prevalent in children and often associated with impairments in several functional domains including sleep. Sleep-wake disturbances (SWD) are common in children with TBI ...

Background Hearing loss of ageing is being reframed as a lifecourse problem with childhood origins. Supporting this theory, recent studies suggest a possible role of obesity, inflammation and telomere shortening in the ...

The type and severity of clinical involvement in children with fragile X syndrome (FXS) and disorders related to premutations (PM) of the fragile X mental retardation 1 gene (FMR1), herein collectively denoted as fragile ...

Infections caused by stomach dwelling bacteria Helicobacter pylori which infect half of the World's population are the main cause of gastric pathologies including peptic ulcers and gastric adenocarcinoma, the latter being ...

Multiple-breath washout (MBW) and tidal flow waveform data, widely used to measure lung function in paediatric settings, are typically analysed using simple empirical summaries rather than statistical models. Yet the data ...

Clown doctors are a feature in paediatric hospitals, visiting children and families, providing a welcome escape from the reality of hospitalisation. Though the use of humour to improve health and wellbeing has been widely ...

Mitochondrial oxidative phosphorylation (OXPHOS) disorders constitute the largest group of inborn errors of metabolism. Complex I (CI) deficiency is the most common enzymatic defect identified within mitochondrial OXPHOS ...

Background Cerebral Palsy (CP) is the most common cause of physical disability affecting children in developed countries. Approximately one third of children with CP may develop hip displacement. Non-ambulant children at ...

Aims: The aims of this thesis were to investigate the (1) extent to which dietary scores and patterns remain stable from 2-3 to 10-11, and from 4-5 to 14-15, years of age; (2) determinants of this stability or change, ...

Oxygen is a long-established medical therapy that can be life-saving for severely ill children admitted to hospital. Effective provision of oxygen to patients requires a multifaceted system that involves technical, clinical, ...