Paediatrics (RCH) - Theses
Now showing items 1-10 of 216
Genetic and early-life environmental influences on dental health in childhood: a study of twins
Through toothache, infection and tooth loss, dental diseases have a major impact on the health and well-being of children. Dental caries and hypomineralised second primary molars (HSPM) are two common diseases of childhood. ...
Development and validation of the short language measure (SLaM): a brief measure of general language ability for children in their first year at school
The identification of children with language difficulties relies on the referral of children to speech-language services. Yet, the referrers of young school-aged children cannot always accurately discriminate those with ...
Circulating microRNAs in Rett syndrome
Rett Syndrome (RTT) is a severe neurological disorder with diagnostic challenges and undetermined patholophysiology. Small regulatory RNAs known as miRNAs are essential in a multiple biological processes, including brain ...
Home intravenous antibiotics in children: determining the population, efficacy, safety and cost-effectiveness using cellulitis as a paradigm
Admission to hospital has a negative impact on quality of life in children, carries the risk of hospital-acquired infections and is associated with higher costs. The alternative to hospital admission for intravenous ...
Defining white matter development over childhood and adolescence
Brain development in childhood and adolescence is a highly dynamic process, governed by the rapid expansion of white matter macrostructure. This volumetric expansion involves the growth and reorganisation of the white ...
The molecular pathology of a collagen II helix missense mutation
Collagen II (COL2A1) is a major structural component of the extracellular matrix in cartilaginous tissues, and mutations that affect the expression or structure of collagen II result in a range of chondrodysplasias. Many ...
Physiologic changes following fluid resuscitation for suspected paediatric sepsis: a point-of-care ultrasound study
Fluid bolus therapy is one of the most commonly administered forms of acute circulatory support in hospitalised children and adults. Early and aggressive fluid bolus therapy has been used as a cornerstone of the treatment ...
Non-invasive arterial wave analysis in congenital heart disease
Elevated large arterial stiffness is an independent risk factor for adult cardiovascular and cerebrovascular disease. Arterial dysfunction may already be evident in childhood, and children born preterm, or with a history ...
Exploring the prevalence, natural history and adverse events related to tree nut allergy
Peanut and tree nut allergies are the most commonly reported trigger of food induced anaphylaxis and fatalities. Whilst most childhood allergies are outgrown by school age, peanut and tree nut allergy resolution has been ...
Disorders of sex development: genetic analysis and development of a novel in vitro cell model
Disorders/Differences of Sex Development (DSDs) are conditions where the chromosomal, anatomical or gonadal sex is atypical. DSDs are caused by a breakdown in the molecular pathways controlling development of the reproductive ...