Paediatrics (RCH) - Theses
Now showing items 1-10 of 200
Examination of key clinical, biological, psychological and social factors associated with post-pubertal anxiety in young people diagnosed with Attention Deficit Hyperactivity Disorder (ADHD)
Introduction: ADHD and anxiety are two common developmental mental health conditions that co-occur in 25% to 33% of young people with ADHD. There are associated functional impairments in these disorders across clinical, ...
Gene therapy for β-thalassaemia: targeted modification of the human β-globin locus
The β-haemoglobinopathies, caused by insufficient synthesis (β-thalassaemia) or structural defects (sickle cell disease) of the β-globin protein, are the most prevalent inherited blood disorders worldwide. Due to severe ...
Early-life predictors of vascular phenotypes : in the Child Health CheckPoint and Longitudinal Study of Australian Children
Background: Cardiovascular disease (CVD) is a leading cause of global mortality and morbidity in the 21st century. The main pathological mechanism in CVD, atherosclerosis, begins early in life. Effective CVD prevention ...
The development of feeding in infants with oesophageal atresia between birth and nine months of age
Feeding problems have been widely reported in babies with oesophageal atresia (OA) and are usually described in terms of growth or oesophageal functioning. The feeding problems may persist into adulthood. The aim of my ...
Adversity, maternal behaviours and child language: a prospective, longitudinal cohort study
Background: Prevalence estimates of language difficulties in children range between 7-13%. When studies focus solely on disadvantaged cohorts, estimates rise to around 30-56%, with difficulties present across language ...
GAPTrap: a novel gene expression system for pluripotent stem cells and their differentiated derivatives
Human induced pluripotent stem cells (iPSCs or iPS cells) are derived by the in vitro reprogramming of somatic cells and resemble embryonic stem cells (hESCs) derived from the inner cell mass of the pre-implantation ...
Changing the face of craniofacial growth curves: modelling growth and sexual dimorphism in children and adolescents using spatially dense 3D image analysis
Accurate descriptions of normal craniofacial shape are essential for accurate assessment of pathologies of the craniofacial complex. Traditionally, these descriptions, have been limited to growth curves of single measurements ...
Minimising complications after surgical repair of coarctation of the aorta
Coarctation of the aorta is one of the most common congenital heart defects, often requiring surgery soon after birth. In Australia alone, approximately 150 babies are born with coarctation each year with an estimated 3,000 ...
Impact of pneumococcal vaccination on carriage in a Fijian population
Streptococcus pneumoniae (the pneumococcus) causes a range of diseases including otitis media, pneumonia and meningitis, and is a major cause of morbidity and mortality in children under five years of age worldwide. ...
Mild and moderate congenital hearing loss in childhood: trends and associations with language outcomes
Background: Children born with mild and moderate bilateral hearing loss experience poorer language outcomes than peers without hearing loss. Following implementation of universal newborn hearing screening (UNHS) in the ...