Paediatrics (RCH) - Theses
Now showing items 1-10 of 222
Statistical modelling of lung function from multiple-breath washout and complex tidal flow waveform data
Multiple-breath washout (MBW) and tidal flow waveform data, widely used to measure lung function in paediatric settings, are typically analysed using simple empirical summaries rather than statistical models. Yet the data ...
Clowns in the midst: understanding clown doctors at The Royal Children's Hospital Melbourne
Clown doctors are a feature in paediatric hospitals, visiting children and families, providing a welcome escape from the reality of hospitalisation. Though the use of humour to improve health and wellbeing has been widely ...
Determining the genetic basis of mitochondrial complex I deficiency in children using massively parallel sequencing
Mitochondrial oxidative phosphorylation (OXPHOS) disorders constitute the largest group of inborn errors of metabolism. Complex I (CI) deficiency is the most common enzymatic defect identified within mitochondrial OXPHOS ...
Proximal femoral osteotomy in children and adolescents with cerebral palsy
Background Cerebral Palsy (CP) is the most common cause of physical disability affecting children in developed countries. Approximately one third of children with CP may develop hip displacement. Non-ambulant children at ...
Determinants and outcomes of dietary trajectories and obesity measures in children/adolescents and their parents: the longitudinal study of Australian children
Aims: The aims of this thesis were to investigate the (1) extent to which dietary scores and patterns remain stable from 2-3 to 10-11, and from 4-5 to 14-15, years of age; (2) determinants of this stability or change, ...
Improving oxygen therapy for children and newborns in Nigerian hospitals
Oxygen is a long-established medical therapy that can be life-saving for severely ill children admitted to hospital. Effective provision of oxygen to patients requires a multifaceted system that involves technical, clinical, ...
Genetic and early-life environmental influences on dental health in childhood: a study of twins
Through toothache, infection and tooth loss, dental diseases have a major impact on the health and well-being of children. Dental caries and hypomineralised second primary molars (HSPM) are two common diseases of childhood. ...
Development and validation of the short language measure (SLaM): a brief measure of general language ability for children in their first year at school
The identification of children with language difficulties relies on the referral of children to speech-language services. Yet, the referrers of young school-aged children cannot always accurately discriminate those with ...
Circulating microRNAs in Rett syndrome
Rett Syndrome (RTT) is a severe neurological disorder with diagnostic challenges and undetermined patholophysiology. Small regulatory RNAs known as miRNAs are essential in a multiple biological processes, including brain ...
Home intravenous antibiotics in children: determining the population, efficacy, safety and cost-effectiveness using cellulitis as a paradigm
Admission to hospital has a negative impact on quality of life in children, carries the risk of hospital-acquired infections and is associated with higher costs. The alternative to hospital admission for intravenous ...