Multiple-breath washout (MBW) and tidal flow waveform data, widely used to measure lung function in paediatric settings, are typically analysed using simple empirical summaries rather than statistical models. Yet the data ...

Clown doctors are a feature in paediatric hospitals, visiting children and families, providing a welcome escape from the reality of hospitalisation. Though the use of humour to improve health and wellbeing has been widely ...

Mitochondrial oxidative phosphorylation (OXPHOS) disorders constitute the largest group of inborn errors of metabolism. Complex I (CI) deficiency is the most common enzymatic defect identified within mitochondrial OXPHOS ...

Background Cerebral Palsy (CP) is the most common cause of physical disability affecting children in developed countries. Approximately one third of children with CP may develop hip displacement. Non-ambulant children at ...

Aims: The aims of this thesis were to investigate the (1) extent to which dietary scores and patterns remain stable from 2-3 to 10-11, and from 4-5 to 14-15, years of age; (2) determinants of this stability or change, ...

Oxygen is a long-established medical therapy that can be life-saving for severely ill children admitted to hospital. Effective provision of oxygen to patients requires a multifaceted system that involves technical, clinical, ...

Through toothache, infection and tooth loss, dental diseases have a major impact on the health and well-being of children. Dental caries and hypomineralised second primary molars (HSPM) are two common diseases of childhood. ...

The identification of children with language difficulties relies on the referral of children to speech-language services. Yet, the referrers of young school-aged children cannot always accurately discriminate those with ...

Rett Syndrome (RTT) is a severe neurological disorder with diagnostic challenges and undetermined patholophysiology. Small regulatory RNAs known as miRNAs are essential in a multiple biological processes, including brain ...

Admission to hospital has a negative impact on quality of life in children, carries the risk of hospital-acquired infections and is associated with higher costs. The alternative to hospital admission for intravenous ...