Paediatrics (RCH) - Theses
Now showing items 1-10 of 192
Impact of pneumococcal vaccination on carriage in a Fijian population
Streptococcus pneumoniae (the pneumococcus) causes a range of diseases including otitis media, pneumonia and meningitis, and is a major cause of morbidity and mortality in children under five years of age worldwide. ...
Mild and moderate congenital hearing loss in childhood: trends and associations with language outcomes
Background: Children born with mild and moderate bilateral hearing loss experience poorer language outcomes than peers without hearing loss. Following implementation of universal newborn hearing screening (UNHS) in the ...
"What about me?": The impact of cystic fibrosis on parental differential treatment, sibling relationships and adjustment
Cystic fibrosis (CF) is an inherited, multisystem disorder that primarily affects the respiratory and digestive systems. Currently, approximately half the individuals with CF in Australia, the United States and Canada are ...
Development, characterisation and nicotinamide riboside treatment of Complex I-deficient model systems
Mitochondrial disorders are the most common inborn error of metabolism, affecting 1 in 5000 live births. Complex I (CI) de ciency is the most common cause of paediatric mitochondrial disease. Deleterious mutations in CI ...
Unveiling the biology of collecting duct epithelium repair and regeneration
The healthy functioning of the kidney requires the orchestrated action of its two functional units, nephrons and the collecting duct system (CD). Therefore malfunction of either of these two essential compartments can lead ...
Wnt signalling pathway in fetal and neonatal cardiopulmonary development
Cardiopulmonary development and maturation involves numerous intracellular protein signalling pathways. Any alteration to these pathways may lead to the development of congenital heart and lung defects. One such important ...
Development of working memory in very preterm children
Children born very preterm (VP; <32 weeks’ gestation) show wide-ranging long-term neuropsychological difficulties compared with their term-born peers, including reduced language, attention, memory and learning. One area ...
Developing cell and gene therapy for Friedreich ataxia
Friedreich ataxia (FRDA) is a debilitating neurodegenerative disorder which affects 1 in 29 000 individuals of Caucasian descent. Disease onset is typically between 10-15 years of age and it is primarily characterised by ...
Using massively parallel sequencing to determine the genetic basis of Leigh Syndrome, the most common mitochondrial disorder affecting children
Mitochondrial diseases are debilitating illnesses caused by mutations that impair mitochondrial energy generation. The most common clinical presentation of mitochondrial disease in children is Leigh syndrome. This ...
Motor outcomes and their impact on activities of daily living, following paediatric arterial ischemic stroke
Paediatric arterial ischaemic stroke (AIS) affects between 1.6-2.7 per 100,000 children per year. Motor impairments are the most commonly reported adverse consequence following paediatric arterial ischaemic stroke, yet the ...