Paediatrics (RCH) - Theses
Now showing items 1-10 of 238
Factors influencing vaccine responses in the first year of life
Immunisation is the most cost-effective life-saving medical intervention and is estimated to save at least 2.5 million lives each year. However, there is substantial variation between individuals in the immune response to ...
Mechanisms of signal transduction and treatment implications in childhood leukaemia
Acute lymphoblastic leukaemia (ALL) is the most common form of paediatric malignancy and while the prognosis for patients has dramatically improved, specific molecular subtypes are still associated with inferior outcomes. ...
Investigating the biology of paediatric T cell acute lymphoblastic leukaemia to facilitate more effective individualised therapy
Acute lymphoblastic leukaemia (ALL) takes up the highest percentage of paediatric cancer. The treatment requires intensive chemotherapy for two to three years, as well as haematopoietic stem cell transplantation for ...
A study of Thromboprophylaxis in the Australian and New Zealand Fontan population
Background: The Fontan procedure was developed approximately 50 years ago and has become the definitive treatment for children born with single ventricle physiology. Surgical refinement of the Fontan technique and ...
The epidemiology and risk factors of anaphylaxis and food-induced anaphylaxis worldwide
Anaphylaxis is a severe allergic reaction that is rapid in onset and may cause death. There are increasing reports from individual countries and regions on anaphylaxis prevalence or incidence; however, there has been no ...
Fontan Procedure in Single Ventricle Patients: Identifying and managing the failing Fontan circulation
The introduction of the strategy of staged surgical palliation, with the Fontan operation as the final stage, has enabled the survival of almost five generations of children born with congenital heart defects that result ...
Characterisation of Hepatitis B virus from chronically infected African children living in Australia
One third of the worlds’ population have evidence of hepatitis B infection making it one of the most important global health problems of this century. The risk of developing chronic hepatitis B is greatest if acquired as ...
Establishing predictive indicators, or biomarkers, of aminoglycoside nephrotoxicity and the Incidence of ototoxicity in children up to six years with cystic fibrosis (PIANO-CF extension)
Cystic Fibrosis (CF) is an autosomal recessive condition caused by a mutation in the cystic fibrosis transmembrane regulator (CFTR) gene. It is commonly known as a disease affecting the lungs. Advances in screening, diagnosis ...
Predictors of complications in anorexia nervosa and atypical anorexia nervosa in adolescents: degree of underweight or extent and recency of weight loss?
Anorexia Nervosa (AN) is the eating disorder characterised by emaciation and underweight, commonly precipitated by dietary restriction that progresses to increasing restriction and self-starvation. AN predominantly develops ...
Using human induced pluripotent stem cells to reveal the molecular pathology involved in osteogenesis imperfecta resulting from two type I collagen C-propeptide mutations
While the genes underlying the genetic brittle bone disease, osteogenesis imperfecta (OI), are well established, the precise pathological mechanisms are unclear. Recent studies have suggested that ER-stress resulting from ...