Medicine (Northwest Academic Centre) - Theses
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Evaluation of coronary stents and atherosclerosis employing optical coherence tomography and computational fluid modelling
Atherosclerotic coronary artery disease (CAD) is a major health burden worldwide and percutaneous coronary intervention (PCI) is an established treatment for this condition. Both PCI and invasive imaging techniques have ...
Screening for asymptomatic coronary heart disease in the siblings of young myocardial infarction patients (SACHSMI)
The concept of screening entails detecting subclinical disease in the hope of altering the natural progression and thereby reducing long term mortality and morbidity. For a screening program to be effective it must be ...
Associations between dietary consumption and cardiometabolic disorders among community-dwelling Australian adults
Background: Cardiometabolic disorders including atherosclerosis, diabetes, and metabolic syndrome (MetS) are major causes of mortality and morbidity. Nutrition is a lifestyle factor that plays an important role in the ...
Genetic study of thyroid eye disease
Thyroid-associated orbitopathy (TO) is an autoimmune-mediated orbital inflammation that affects 25% of patients with Graves’ disease. The close temporal relationship between onset of Graves’ disease and TO suggests they ...
The pattern of expression of the receptor tyrosine kinases (RTK) EphB1, EphB2 and EphB4 in colorectal cancer
Colorectal cancer (CRC) is a global health problem. It is the second leading cause of cancer related death worldwide and in Australia. Around 25% of CRC will experience recurrences postoperatively in the absence of lymph ...
The role of placental heparan sulphate proteoglycans in the pathogenesis of pre-eclampsia
Introduction: Uncomplicated pregnancies represent a hypercoaguable state. However, placental thrombosis is rare in these pregnancies which suggests that thrombin generation must be tightly regulated. In contrast, pregnancy ...
Vitamin D and HIV: exploring determinants of 25-hydroxyvitamin D and altered vitamin D metabolism in HIV-infected adults
Background: Vitamin D deficiency is a widespread global problem of particular importance for people with HIV. Vitamin D is an important hormone for endocrine and extra-endocrine functions, including modulating the immune ...
Sun exposure and type 2 diabetes mellitus: Can sun exposure lower type 2 diabetes risk?
Background: Lower serum 25-hydroxyvitamin D (25OHD) levels have been consistently associated with increased type 2 diabetes mellitus (T2DM) prevalence and incidence in systematic reviews and meta-analyses of observational ...
The treatment of prosthetic joint infection with debridement, prosthesis retention and biofilm-active antibiotics
Background: Prosthetic joint infection (PJI) is a serious infection that is difficult to cure and is associated with significant morbidity. The pathogenesis of PJI involves bacteria growing in biofilm adherent to the ...
Cross‐priming of TCD8+ specific for cell‐associated antigens
TCD8+ of the adaptive immune system play critical roles in the host defence against viruses and other pathogens through elimination of infected host cells. After infection, TCD8+ proliferate and adopt effector functions ...