Medicine (St Vincent's) - Research Publications
Now showing items 1-10 of 243
Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats
(PUBLIC LIBRARY SCIENCE, 2014-05-01)
The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as ...
Performance of formulas for estimating glomerular filtration rate in Indigenous Australians with and without Type 2 diabetes: the eGFR Study
Aims It has been proposed that the Chronic Kidney Disease Epidemiology Collaboration formula estimates glomerular filtration rate more accurately than the Modification of Diet in Renal Disease formula. With the very high ...
Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children
(CAMBRIDGE UNIV PRESS, 2013-12-27)
Healthy food subsidy programmes have not been widely implemented in high-income countries apart from the USA and the UK. There is, however, interest being expressed in the potential of healthy food subsidies to complement ...
Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response
Recent studies have shown that a single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene plays a major role in predicting therapeutic response in hepatitis C virus (HCV)-infected patients treated with ...
Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis
Background: The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have ...
Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome
(OXFORD UNIV PRESS INC, 2015-09-01)
BACKGROUND: Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to ...
The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
(PUBLIC LIBRARY SCIENCE, 2015-04-01)
RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS ...
Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis
Metastasis to regional lymph nodes is an important and early event in many tumors. Vascular endothelial growth factor-C (VEGF-C), VEGF-D and their receptor VEGFR-3, play a role in tumor spread via the lymphatics, although ...
Seizure Prediction: Science Fiction or Soon to Become Reality?
This review highlights recent developments in the field of epileptic seizure prediction. We argue that seizure prediction is possible; however, most previous attempts have used data with an insufficient amount of information ...
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
(NATURE PUBLISHING GROUP, 2014-03-01)
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis ...