Medicine (St Vincent's) - Research Publications
Now showing items 1-10 of 243
Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats
(PUBLIC LIBRARY SCIENCE, 2014-05-01)
The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as ...
Performance of formulas for estimating glomerular filtration rate in Indigenous Australians with and without Type 2 diabetes: the eGFR Study
Aims It has been proposed that the Chronic Kidney Disease Epidemiology Collaboration formula estimates glomerular filtration rate more accurately than the Modification of Diet in Renal Disease formula. With the very high ...
Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children
(CAMBRIDGE UNIV PRESS, 2013-12-27)
Healthy food subsidy programmes have not been widely implemented in high-income countries apart from the USA and the UK. There is, however, interest being expressed in the potential of healthy food subsidies to complement ...
Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response
Recent studies have shown that a single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene plays a major role in predicting therapeutic response in hepatitis C virus (HCV)-infected patients treated with ...
Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis
Background: The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have ...
The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
(PUBLIC LIBRARY SCIENCE, 2015-04-01)
RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS ...
Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength
(PUBLIC LIBRARY SCIENCE, 2011-11-07)
Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of ...
Vaginally Administered PEGylated LIF Antagonist Blocked Embryo Implantation and Eliminated Non-Target Effects on Bone in Mice
(PUBLIC LIBRARY SCIENCE, 2011-05-18)
Female-controlled contraception/HIV prevention is critical to address health issues associated with gender inequality. Therefore, a contraceptive which can be administered in tandem with a microbicide to inhibit sexually ...
Is RANKL inhibition both anti-resorptive and anabolic in rheumatoid arthritis?
(BIOMED CENTRAL LTD, 2015-11-17)
A small peptide, OP3-4, blocks receptor activator of NF-κB from binding to its ligand, receptor activator of NF-κB ligand (RANKL), and was reported recently to inhibit bone resorption, promote bone formation and protect ...
Dysfunctional Muscle and Liver Glycogen Metabolism in mdx Dystrophic Mice
(PUBLIC LIBRARY SCIENCE, 2014-03-13)
BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe, genetic muscle wasting disorder characterised by progressive muscle weakness. DMD is caused by mutations in the dystrophin (dmd) gene resulting in very low levels ...