Medicine (St Vincent's) - Research Publications
Now showing items 1-10 of 209
Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats
(PUBLIC LIBRARY SCIENCE, 2014-05-01)
The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as ...
Performance of formulas for estimating glomerular filtration rate in Indigenous Australians with and without Type 2 diabetes: the eGFR Study
Aims It has been proposed that the Chronic Kidney Disease Epidemiology Collaboration formula estimates glomerular filtration rate more accurately than the Modification of Diet in Renal Disease formula. With the very high ...
Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children
(CAMBRIDGE UNIV PRESS, 2013-12-27)
Healthy food subsidy programmes have not been widely implemented in high-income countries apart from the USA and the UK. There is, however, interest being expressed in the potential of healthy food subsidies to complement ...
Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response
Recent studies have shown that a single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene plays a major role in predicting therapeutic response in hepatitis C virus (HCV)-infected patients treated with ...
Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis
Background: The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have ...
HIV Infection and TLR Signalling in the Liver
(HINDAWI LTD, 2012-01-01)
Despite the availability of effective combination antiretroviral therapy (cART), liver disease is one of the leading causes of morbidity and mortality in Human Immunodeficiency Virus (HIV)-infected individuals, specifically, ...
Chronic Hepatitis B Infection and Pregnancy
(LIPPINCOTT WILLIAMS & WILKINS, 2012-01-01)
UNLABELLED: It is estimated that 350 to 400 million individuals worldwide are chronically infected with hepatitis B virus (HBV). In regions of high endemicity, many of these are females of reproductive age who are an ...
Outcomes following large joint arthroplasty: does socio-economic status matter?
(BIOMED CENTRAL LTD, 2014-05-06)
BACKGROUND: We sought to determine whether socio-economic status (SES) is an independent predictor of outcome following total knee (TKR) and hip (THR) replacement in Australians. METHODS: In this prospective cohort study, ...
The role of ectonucleotidases CD39 and CD73 and adenosine signaling in solid organ transplantation
(FRONTIERS RESEARCH FOUNDATION, 2014-02-18)
Extracellular adenosine is a potent immunomodulatory molecule that accumulates in states of inflammation. Nucleotides such as adenosine triphosphate and adenosine diphosphate are release from injured and necrotic cells and ...
Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy
The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however, natural killer T (NKT) cell abnormalities have been reported in patients with MM, and therapeutic targeting of NKT cells is ...