Medicine (St Vincent's) - Research Publications
Now showing items 1-10 of 243
Brain Remodelling following Endothelin-1 Induced Stroke in Conscious Rats
(PUBLIC LIBRARY SCIENCE, 2014-05-01)
The extent of stroke damage in patients affects the range of subsequent pathophysiological responses that influence recovery. Here we investigate the effect of lesion size on development of new blood vessels as well as ...
Performance of formulas for estimating glomerular filtration rate in Indigenous Australians with and without Type 2 diabetes: the eGFR Study
Aims It has been proposed that the Chronic Kidney Disease Epidemiology Collaboration formula estimates glomerular filtration rate more accurately than the Modification of Diet in Renal Disease formula. With the very high ...
Nutritional impacts of a fruit and vegetable subsidy programme for disadvantaged Australian Aboriginal children
(CAMBRIDGE UNIV PRESS, 2013-12-27)
Healthy food subsidy programmes have not been widely implemented in high-income countries apart from the USA and the UK. There is, however, interest being expressed in the potential of healthy food subsidies to complement ...
Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response
Recent studies have shown that a single-nucleotide polymorphism upstream of the interleukin-28B (IL28B) gene plays a major role in predicting therapeutic response in hepatitis C virus (HCV)-infected patients treated with ...
Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis
Background: The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have ...
The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation
(PUBLIC LIBRARY SCIENCE, 2015-04-01)
RECQL4 mutations are associated with Rothmund Thomson Syndrome (RTS), RAPADILINO Syndrome and Baller-Gerold Syndrome. These patients display a range of benign skeletal abnormalities such as low bone mass. In addition, RTS ...
Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis
Metastasis to regional lymph nodes is an important and early event in many tumors. Vascular endothelial growth factor-C (VEGF-C), VEGF-D and their receptor VEGFR-3, play a role in tumor spread via the lymphatics, although ...
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids
(NATURE PUBLISHING GROUP, 2014-03-01)
Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis ...
Patterns of dietary intake and psychological distress in older Australians: benefits not just from a Mediterranean diet
(CAMBRIDGE UNIV PRESS, 2013-03-01)
BACKGROUND: Anxiety and depression contribute to morbidity in elderly adults and may be associated with diet. We investigated the association between diet and psychological distress as a marker for depression. METHODS: ...
Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength
(PUBLIC LIBRARY SCIENCE, 2011-11-07)
Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of ...