Exercise testing is widely used for risk stratification of ischaemic heart disease, however, its application in other cardiovascular conditions, specifically heart failure and other disease states is less defined. Heart ...

Inflammation plays a crucial role in the pathophysiology of atherosclerosis and clinical manifestation of acute coronary syndromes (ACS). Despite optimal medical therapy and contemporary percutaneous coronary intervention ...

Autoimmune disorders like type 1 diabetes (T1D) result from the failure of immune tolerance mechanisms. Antigen-specific therapy constitutes an attractive approach to re-establish a tolerant state but has so far not been ...

Seizure forecasting, like weather forecasting, was once considered the domain of charlatans and purveyors of science fiction. However, neuroscience has now advanced to the point of translating seizure forecasting research ...

Antiphospholipid syndrome (APS) is an autoimmune disorder in antibodies are generated against cell membrane and self-antigens (aPL-ab) hence the name Antiphospholipid disorder. This autoimmune disorder characterised by the ...

Parathyroid hormone-related protein (PTHrP) is an autocrine/paracrine regulator in many tissues, including bone and mammary glands. Mice with conditional deletion of PTHrP in the osteoblast lineage showed an osteopenic ...

Since its inception, palliative care practice has evolved to respond to the emerging evidence base and the needs of the population it serves. This has resulted in the increasing health system focus on models of early ...

Epilepsy is a chronic neurological condition, characterized by recurrent seizures. Treatment with conventional anti-epileptic drugs (AED) results in only 33% of patients having no seizure recurrence after a prolonged period. ...

It has been over fifty years since the discovery of the hepatitis B virus (HBV) and yet the disease it causes remains a major public health challenge. Worldwide, over 257 million people have chronic hepatitis B (CHB), with ...

ASCIZ (ATM-substrate Chk2-interacting Zn2+ finger protein) is a conserved and highly specialised transcription factor for Dynein light chain 1 (Dynll1) expression. ASCIZ is able to sense DYNLL1 protein levels and thereby ...