Medicine (St Vincent's) - Theses
Now showing items 1-10 of 156
Novel aspects of commonly encountered pituitary adenomas in clinical practice
Clinically relevant pituitary adenomas are common in the general population occurring in 1 per 865-1470 people. Prolactinomas and non-functioning pituitary adenomas account for more than 80% of pituitary adenoma types. My ...
Echocardiographic evaluation of the evolution of cardiac dysfunction in the community and risk of heart failure, using the SCReening Evaluation of the Evolution of New Heart Failure (SCREEN-HF) cohort
Heart failure (HF) is a major cause of morbidity and mortality in the community. Outcomes for HF with reduced ejection fraction (HFrEF) remain poor despite available treatments, and no medical therapy has been shown to ...
Predicting response to anti-TNF therapy in Crohn's disease: clinical and metabolic studies
Crohn’s disease is a chronic, disabling inflammatory condition that affects the gastrointestinal tract that is associated with significant morbidity. Up to 80 percent of patients require surgery at some point in their ...
Topographic rod function in intermediate age-related macular degeneration
Background Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the elderly. In the early stages of disease, dark adaptation problems are more significant for patients than visual acuity ...
An Australian population-based study of the incidence and outcomes of hepatocellular carcinoma: the Hepatomas of Melbourne Epidemiological Research (HoMER) study
Liver cancer, the world’s second highest cause of cancer death, is reportedly increasing in incidence in developed countries including Australia. Hepatocellular carcinoma (HCC), the predominant type of liver cancer, has a ...
Quality of life outcomes following surgery for extremity sarcoma in Victoria, Australia: an observational prospective cohort study
This study was part of the Victorian Sarcoma Service (VSS) – a statewide Australian service comprising multidisciplinary teams dedicated to managing sarcoma. We followed a cohort of 76 people from the time of diagnosis of ...
Investigating the natural history, serologic and genetic associations with disease outcomes, disability and cost of care in inflammatory bowel disease
Inflammatory bowel disease (IBD) is an emerging global health condition. In the second half of the 20th century, the incidence of Crohn’s disease (CD) and ulcerative colitis (UC) increased dramatically in the Western world. ...
Integration of advanced echocardiographic metrics and biomarkers to the fields of heart failure and exercise physiology in the era of precision medicine
Exercise testing is widely used for risk stratification of ischaemic heart disease, however, its application in other cardiovascular conditions, specifically heart failure and other disease states is less defined. Heart ...
Inflammation in atherosclerosis: exploring novel risk factors, prognostic markers and role of colchicine as an anti-inflammatory therapy in acute coronary syndromes
Inflammation plays a crucial role in the pathophysiology of atherosclerosis and clinical manifestation of acute coronary syndromes (ACS). Despite optimal medical therapy and contemporary percutaneous coronary intervention ...
New approaches to induce tolerance in autoantigen-specific memory T cells in type 1 diabetes
Autoimmune disorders like type 1 diabetes (T1D) result from the failure of immune tolerance mechanisms. Antigen-specific therapy constitutes an attractive approach to re-establish a tolerant state but has so far not been ...