Medicine (St Vincent's) - Theses
Now showing items 1-10 of 143
Towards the integration of palliative care in advanced cancer: an exploration of patient, family and community perceptions of palliative care and views of communication
Since its inception, palliative care practice has evolved to respond to the emerging evidence base and the needs of the population it serves. This has resulted in the increasing health system focus on models of early ...
Initial development of an implantable drug delivery device for the treatment of epilepsy
Epilepsy is a chronic neurological condition, characterized by recurrent seizures. Treatment with conventional anti-epileptic drugs (AED) results in only 33% of patients having no seizure recurrence after a prolonged period. ...
The B cell response in chronic Hepatitis B: milestones on the road to a cure
It has been over fifty years since the discovery of the hepatitis B virus (HBV) and yet the disease it causes remains a major public health challenge. Worldwide, over 257 million people have chronic hepatitis B (CHB), with ...
The role of ASCIZ and Dynein light chain-1 in embryonic development
ASCIZ (ATM-substrate Chk2-interacting Zn2+ finger protein) is a conserved and highly specialised transcription factor for Dynein light chain 1 (Dynll1) expression. ASCIZ is able to sense DYNLL1 protein levels and thereby ...
The molecular interface between the Fanconi anemia and Bloom’s Syndrome DNA repair pathways
The link between DNA repair and cancer can clearly be seen in DNA repair defective disorders such as Fanconi anemia (FA) and Bloom’s syndrome. Both disorders result in an increase sensitivity to DNA damaging agents, genome ...
Mechanisms of activation and inhibition of the metabolic regulator AMP-activated protein kinase (AMPK)
Biochemical energy in the form of ATP is crucial for normal metabolic function of all cells. Relative levels of AMP, ADP and ATP reflect the energy status of the cell, and are described in a single parameter called the ...
Perioperative cardiovascular complications: incidence in patients undergoing cancer surgery and preoperative risk prediction using 18F-fluorodeoxyglucose cardiac positron emission tomography imaging
Background: Major perioperative cardiac complications affect over 10 million patients annually worldwide. Cancer is associated with multiple shared cardiovascular risk factors, but the incidence of cardiovascular complications ...
Development of the Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI): a novel instrument to quantify organ damage in systemic sclerosis
Objective: Systemic Sclerosis (SSc) is a multi-organ connective tissue disease resulting in fibrosis of the skin and internal organs. We sought to develop the first damage index (DI) in systemic sclerosis (SSc). Methods: ...
Immunological and microbiological studies in post-operative Crohn's disease
Crohn’s disease is a chronic, inflammatory condition of the bowel. The aetiology of Crohn’s has not been fully elucidated, but is believed to arise from the interaction between the gut microbiota, the host immune system ...
Quantifying organ damage in systemic sclerosis: rationale, methodology and item generation
Purpose: The overall purpose of this thesis is to form a rationale for the development of a disease damage index in systemic sclerosis and to inform item generation for inclusion in this index through: (1) appraisal of ...