Medicine (St Vincent's) - Theses
Now showing items 1-10 of 153
Topographic rod function in intermediate age-related macular degeneration
Background Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the elderly. In the early stages of disease, dark adaptation problems are more significant for patients than visual acuity ...
An Australian population-based study of the incidence and outcomes of hepatocellular carcinoma: the Hepatomas of Melbourne Epidemiological Research (HoMER) study
Liver cancer, the world’s second highest cause of cancer death, is reportedly increasing in incidence in developed countries including Australia. Hepatocellular carcinoma (HCC), the predominant type of liver cancer, has a ...
Quality of life outcomes following surgery for extremity sarcoma in Victoria, Australia: an observational prospective cohort study
This study was part of the Victorian Sarcoma Service (VSS) – a statewide Australian service comprising multidisciplinary teams dedicated to managing sarcoma. We followed a cohort of 76 people from the time of diagnosis of ...
Investigating the natural history, serologic and genetic associations with disease outcomes, disability and cost of care in inflammatory bowel disease
Inflammatory bowel disease (IBD) is an emerging global health condition. In the second half of the 20th century, the incidence of Crohn’s disease (CD) and ulcerative colitis (UC) increased dramatically in the Western world. ...
Integration of advanced echocardiographic metrics and biomarkers to the fields of heart failure and exercise physiology in the era of precision medicine
Exercise testing is widely used for risk stratification of ischaemic heart disease, however, its application in other cardiovascular conditions, specifically heart failure and other disease states is less defined. Heart ...
Inflammation in atherosclerosis: exploring novel risk factors, prognostic markers and role of colchicine as an anti-inflammatory therapy in acute coronary syndromes
Inflammation plays a crucial role in the pathophysiology of atherosclerosis and clinical manifestation of acute coronary syndromes (ACS). Despite optimal medical therapy and contemporary percutaneous coronary intervention ...
New approaches to induce tolerance in autoantigen-specific memory T cells in type 1 diabetes
Autoimmune disorders like type 1 diabetes (T1D) result from the failure of immune tolerance mechanisms. Antigen-specific therapy constitutes an attractive approach to re-establish a tolerant state but has so far not been ...
Epileptic seizures: mechanisms and forecasting
Seizure forecasting, like weather forecasting, was once considered the domain of charlatans and purveyors of science fiction. However, neuroscience has now advanced to the point of translating seizure forecasting research ...
Role of purinergic signalling in the pathophysiology of antiphospholipid antibody induced miscarriages
Antiphospholipid syndrome (APS) is an autoimmune disorder in antibodies are generated against cell membrane and self-antigens (aPL-ab) hence the name Antiphospholipid disorder. This autoimmune disorder characterised by the ...
Physiological role of osteocytic parathyroid hormone-related protein (PTHrP)
Parathyroid hormone-related protein (PTHrP) is an autocrine/paracrine regulator in many tissues, including bone and mammary glands. Mice with conditional deletion of PTHrP in the osteoblast lineage showed an osteopenic ...