Medicine (St Vincent's) - Theses
Now showing items 1-10 of 149
Integration of advanced echocardiographic metrics and biomarkers to the fields of heart failure and exercise physiology in the era of precision medicine
Exercise testing is widely used for risk stratification of ischaemic heart disease, however, its application in other cardiovascular conditions, specifically heart failure and other disease states is less defined. Heart ...
Inflammation in atherosclerosis: exploring novel risk factors, prognostic markers and role of colchicine as an anti-inflammatory therapy in acute coronary syndromes
Inflammation plays a crucial role in the pathophysiology of atherosclerosis and clinical manifestation of acute coronary syndromes (ACS). Despite optimal medical therapy and contemporary percutaneous coronary intervention ...
New approaches to induce tolerance in autoantigen-specific memory T cells in type 1 diabetes
Autoimmune disorders like type 1 diabetes (T1D) result from the failure of immune tolerance mechanisms. Antigen-specific therapy constitutes an attractive approach to re-establish a tolerant state but has so far not been ...
Epileptic seizures: mechanisms and forecasting
Seizure forecasting, like weather forecasting, was once considered the domain of charlatans and purveyors of science fiction. However, neuroscience has now advanced to the point of translating seizure forecasting research ...
Role of purinergic signalling in the pathophysiology of antiphospholipid antibody induced miscarriages
Antiphospholipid syndrome (APS) is an autoimmune disorder in antibodies are generated against cell membrane and self-antigens (aPL-ab) hence the name Antiphospholipid disorder. This autoimmune disorder characterised by the ...
Physiological role of osteocytic parathyroid hormone-related protein (PTHrP)
Parathyroid hormone-related protein (PTHrP) is an autocrine/paracrine regulator in many tissues, including bone and mammary glands. Mice with conditional deletion of PTHrP in the osteoblast lineage showed an osteopenic ...
Towards the integration of palliative care in advanced cancer: an exploration of patient, family and community perceptions of palliative care and views of communication
Since its inception, palliative care practice has evolved to respond to the emerging evidence base and the needs of the population it serves. This has resulted in the increasing health system focus on models of early ...
Initial development of an implantable drug delivery device for the treatment of epilepsy
Epilepsy is a chronic neurological condition, characterized by recurrent seizures. Treatment with conventional anti-epileptic drugs (AED) results in only 33% of patients having no seizure recurrence after a prolonged period. ...
The B cell response in chronic Hepatitis B: milestones on the road to a cure
It has been over fifty years since the discovery of the hepatitis B virus (HBV) and yet the disease it causes remains a major public health challenge. Worldwide, over 257 million people have chronic hepatitis B (CHB), with ...
The role of ASCIZ and Dynein light chain-1 in embryonic development
ASCIZ (ATM-substrate Chk2-interacting Zn2+ finger protein) is a conserved and highly specialised transcription factor for Dynein light chain 1 (Dynll1) expression. ASCIZ is able to sense DYNLL1 protein levels and thereby ...