Lung cancer remains the most common cause of cancer related death worldwide, with nearly 1.4 million deaths in 2008 globally. Adenocarcinoma is the most common type of lung cancer, and its frequency compared to other ...

Genetic generalised epilepsies (GGE) are a common, but under-studied cluster of epileptic syndromes of predominantly child and adolescent onset. The primary syndromes of GGE are childhood absence epilepsy (CAE), juvenile ...

Duchenne muscular dystrophy (DMD) is the most common form of muscular dystrophy in children. It is due to an X-linked recessive mutation in the dystrophin gene resulting in the lack of, or production of non-functional, ...

Protein-protein interactions play a key role in biological processes. With experimental data showing an increasing number of protein-protein interactions being important in tumorigenesis and progression, structure-guided ...

Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide, affecting an estimated 2 billion people globally. In spite of safe vaccination and effective therapy, there is still a large burden ...

Background: The rising prevalence of prostate cancer in Australia will increasingly contribute significant morbidity, mortality and economic burden on society. Radical prostatectomy is the mainstay of treatment for localised ...

Progressive chronic kidney disease (CKD) is a major health problem in Australia, and its prevalence is increasing due to the growing incidence of diabetes and hypertension. However, current clinical management of CKD, ...

Immune responses to proinsulin initiate anti-islet autoimmunity in non-obese diabetic (NOD) mice and possibly in humans. This results in autoimmune destruction of insulin secreting beta cells leading to type 1 diabetes ...

Chronic wounds are a major problem in the health care system. The increasing incidence of obesity and diabetes and longer life expectancy are adding to the burden. Treatment options are currently limited indicating needs ...

Barrett’s Oesophagus (BE) is a condition whereby the columnar cells that normally line the oesophagus are replaced by an intestinal metaplastic cell type. Over time, these new cells can become dysplastic and ultimately can ...