Obstetrics and Gynaecology - Research Publications

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Combination Gefitinib and Methotrexate Compared With Methotrexate Alone to Treat Ectopic Pregnancy

Skubisz, M; Horne, AH; Johns, TJ; Nilsson, UN; Duncan, CD; Wallace, EW; Critchley, HC; Tong, S (2013)

OBJECTIVE: To determine the safety, tolerability, and efficacy of combination gefitinib and methotrexate to treat ectopic pregnancy.METHODS: We performed a phase I, single-arm (non-randomized), open-label study. Twelve ...

Altered decorin leads to disrupted endothelial cell function: A possible mechanism in the pathogenesis of fetal growth restriction?

Chui, A.; Murthi, P.; Gunatillake, T.; Brennecke, S. P.; Ignjatovic, V.; Monagle, P.T.; Whitelock, J. M.; Said, J. M. (ELSEVIER, 2014-08-27)

Objective: Fetal growth restriction (FGR) is a key cause of adverse pregnancy outcome where maternal and fetal factors are identified as contributing to this condition. Idiopathic FGR is associated with altered vascular ...

Common fibroid-associated genes are differentially expressed in phenotypically dissimilar cell populations isolated from within human fibroids and myometrium

Holdsworth-Carson, Sarah J.; Zaitseva, Marina; Girling, Jane E.; Vollenhoven, Beverley J.; Rogers, Peter A. W. (BIOSCIENTIFICA LTD, 2014-05-27)

Uterine fibroids are a prevalent gynaecological condition in reproductive-aged women and are the commonest reason for hysterectomy. The cellular composition of clonal fibroids are heterogeneous, with phenotypically dissimilar ...

Fall in Human Papillomavirus Prevalence Following a National Vaccination Program

Tabrizi, Sepehr N.; Brotherton, Julia M. L.; Kaldor, John M.; Skinner, S. Rachel; Cummins, Eleanor; Liu, Bette; Bateson, Deborah; McNamee, Kathleen; Garefalakis, Maria; Garland, Suzanne M. (OXFORD UNIV PRESS INC, 2012-12-27)

Methods. HPV genoprevalence in women aged 18-24 years attending family planning clinics in the prevaccine period (2005-2007) was compared with prevalence among women of the same age group in the postvaccine period (2010-2011). ...

Aberrant expression and regulation of NR2F2 and CTNNB1 in uterine fibroids

Zaitseva, Marina; Holdsworth-Carson, Sarah J.; Waldrip, Luke; Nevzorova, Julia; Martelotto, Luciano; Vollenhoven, Beverley J.; Rogers, Peter A. W. (BIOSCIENTIFICA LTD, 2013-08-27)

Uterine fibroids are the most common benign tumour afflicting women of reproductive age. Despite the large healthcare burden caused by fibroids, there is only limited understanding of the molecular mechanisms that drive ...

Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

Skubisz, Monika M.; Brown, Jeremy K.; Tong, Stephen; Kaitu'u-Lino, Tu'uhevaha; Horne, Andrew W. (PUBLIC LIBRARY SCIENCE, 2013)

Background: Ectopic pregnancy (EP) occurs in 1-2% of pregnancies, but is over-represented as a leading cause of maternal death in early pregnancy. It remains a challenge to diagnose early and accurately. Women often present ...

Using a decline in serum hCG between days 0-4 to predict ectopic pregnancy treatment success after single-dose methotrexate: a retrospective cohort study

Skubisz, Monika; Dutton, Philip; Duncan, William Colin; Horne, Andrew W.; Tong, Stephen (BIOMED CENTRAL LTD, 2013)

Background: The current measure of treatment efficacy of single-dose methotrexate for ectopic pregnancy, is a fall in serum hCG of >= 15% between days 4-7 of treatment, which has a positive predictive value of 93% for ...

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