Understanding the contribution of iron in traumatic brain injury (TBI)
AuthorLam, Linh Quy
AffiliationPharmacology and Therapeutics
Document TypePhD thesis
Access StatusThis item is embargoed and will be available on 2020-03-13. This item is currently available to University of Melbourne staff and students only, login required.
© 2017 Dr Linh Quy Lam
Traumatic brain injury (TBI) is a socioeconomic burden and the underlying mechanisms that govern iron homeostasis after TBI is not fully elucidated. Evidently, iron accumulation observed after injury can contribute to the exacerbation of cellular consequences. Yet, the iron content observed might not all originate from haemorrhage, as non-heme iron is also evident. Interestingly, the alterations of iron-regulatory proteins such as amyloid precursor protein (APP), ceruloplasmin (CP), ferritin (Ft) and ferroportin (Fpn) may all be contributing factors to iron dyshomeostasis after TBI. Therefore, understanding the contribution of iron after TBI can deepen our understanding of iron-regulation and assist in the development of therapeutics to target iron-related insults after injury.
Keywordsneuroscience; traumatic brain injury; iron
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