Epidermal growth factor receptor (EGFR) signaling is one of the most avidly studied signaling networks in mammalian biology, with critical roles in cellular growth and survival. The EGFR is also vital for normal placental ...

Background: The development of diabetes mellitus during pregnancy, referred to as gestational diabetes (GDM), is associated with adverse maternal and fetal outcomes. Routine screening for this condition is therefore ...

Epithelial ovarian cancer (EOC) is the most lethal of the gynaecologic malignancies, with an overall 5-year survival rate of only <30%. This poor prognosis is due to the advanced-stage disease at initial diagnosis in ...

Background: Monitoring heart rate in newborns and infants is crucially important in guiding resuscitation and medical care. Established methods for heart rate assessment of these children have inherent drawbacks. In recent ...

Background Preterm birth is a major cause of morbidity and mortality worldwide. Respiratory distress syndrome is an important complication of preterm birth, and there is increasing evidence that ‘non-invasive’ respiratory ...

Preeclampsia complicates 5-8% of pregnancies and is responsible for 60,000 maternal deaths and far greater numbers of perinatal deaths annually. Disappointingly these statistics have remained static over the last 50 years, ...

Introduction: Pre-eclampsia (PE) has affected pregnant women throughout human history and remains a leading cause of maternal and fetal mortality and morbidity worldwide today. PE is clinically characterised by de novo ...

Epithelial ovarian cancer (EOC) is the most lethal of all the gynaecological malignancies with a five year mortality rate of >70%. The majority of EOC cases are diagnosed at advanced metastatic stages. Here, the disease ...

Introduction: Uncomplicated pregnancies represent a hypercoaguable state. However, placental thrombosis is rare in these pregnancies which suggests that thrombin generation must be tightly regulated. In contrast, pregnancy ...

Synchrotron microbeam radiation therapy (MRT) is a novel, preclinical form of treatment that has proven effective at ablating tumours in a range of animal models, with significantly reduced damage to adjacent normal tissues. ...