Obstetrics and Gynaecology - Theses
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The role of decidual mesenchymal stem/stromal cell ageing in labour
Ageing and parturition share many common pathways, but whether these two processes are associated, or even dependent on each other, is poorly understood. This study focuses on the decidua, where there is evidence that ...
Midpregnancy prediction of preeclampsia
AIM: Placental biomarkers soluble Fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF), when tested at midpregnancy, may predict preeclampsia. This thesis investigates testing PlGF and the sFlt1/PlGF ratio ...
The response of normal tissues to synchrotron microbeam radiotherapy
This thesis presents multidisciplinary and collaborative research aimed at translating microbeam radiation therapy (MRT) to clinical trials. MRT is a novel pre-clinical synchrotron-based radiation therapy modality that is ...
The role of decidual mesenchymal stem/stromal cells and their secreted extracellular vesicles in ageing of the human placenta
Ageing is an inevitable process associated with age-related diseases. Unhealthy ageing is a major risk factor for many chronic diseases including cardiovascular and neurodegenerative diseases. The human placenta, despite ...
Improving the detection of risk factors for stillbirth
Stillbirth is a global tragedy, claiming over 2.6 million lives annually. In Australia, seven in 1000 babies are stillborn - a figure that has remained static over the last three decades. The majority of stillbirths after ...
Synchrotron radiation therapy for the treatment of cancer
Despite advances in radiation oncology there remain numerous clinical scenarios where radiation therapy, in conjunction with other cancer therapies, is unable to significantly improve disease prognosis. Advanced lung cancer, ...
Targeting Epidermal Growth Factor to treat pregnancy complications
Epidermal growth factor receptor (EGFR) signaling is one of the most avidly studied signaling networks in mammalian biology, with critical roles in cellular growth and survival. The EGFR is also vital for normal placental ...
Impact of new criteria for the diagnosis of gestational diabetes: a maternal and neonatal health outcome and economic analysis in a large tertiary level maternity centre
Background: The development of diabetes mellitus during pregnancy, referred to as gestational diabetes (GDM), is associated with adverse maternal and fetal outcomes. Routine screening for this condition is therefore ...
Cancer stem cell-associated pathways regulating chemoresistance in ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal of the gynaecologic malignancies, with an overall 5-year survival rate of only <30%. This poor prognosis is due to the advanced-stage disease at initial diagnosis in ...
Novel technology for the measurement of newborn and infant heart rate
Background: Monitoring heart rate in newborns and infants is crucially important in guiding resuscitation and medical care. Established methods for heart rate assessment of these children have inherent drawbacks. In recent ...