AIM: Placental biomarkers soluble Fms-like tyrosine kinase-1 (sFlt1) and placental growth factor (PlGF), when tested at midpregnancy, may predict preeclampsia. This thesis investigates testing PlGF and the sFlt1/PlGF ratio ...

This thesis presents multidisciplinary and collaborative research aimed at translating microbeam radiation therapy (MRT) to clinical trials. MRT is a novel pre-clinical synchrotron-based radiation therapy modality that is ...

Ageing is an inevitable process associated with age-related diseases. Unhealthy ageing is a major risk factor for many chronic diseases including cardiovascular and neurodegenerative diseases. The human placenta, despite ...

Stillbirth is a global tragedy, claiming over 2.6 million lives annually. In Australia, seven in 1000 babies are stillborn - a figure that has remained static over the last three decades. The majority of stillbirths after ...

Despite advances in radiation oncology there remain numerous clinical scenarios where radiation therapy, in conjunction with other cancer therapies, is unable to significantly improve disease prognosis. Advanced lung cancer, ...

Epidermal growth factor receptor (EGFR) signaling is one of the most avidly studied signaling networks in mammalian biology, with critical roles in cellular growth and survival. The EGFR is also vital for normal placental ...

Background: The development of diabetes mellitus during pregnancy, referred to as gestational diabetes (GDM), is associated with adverse maternal and fetal outcomes. Routine screening for this condition is therefore ...

Epithelial ovarian cancer (EOC) is the most lethal of the gynaecologic malignancies, with an overall 5-year survival rate of only <30%. This poor prognosis is due to the advanced-stage disease at initial diagnosis in ...

Background: Monitoring heart rate in newborns and infants is crucially important in guiding resuscitation and medical care. Established methods for heart rate assessment of these children have inherent drawbacks. In recent ...

Background Preterm birth is a major cause of morbidity and mortality worldwide. Respiratory distress syndrome is an important complication of preterm birth, and there is increasing evidence that ‘non-invasive’ respiratory ...