Obstetrics and Gynaecology - Theses
Now showing items 1-10 of 27
Targeting Epidermal Growth Factor to treat pregnancy complications
Epidermal growth factor receptor (EGFR) signaling is one of the most avidly studied signaling networks in mammalian biology, with critical roles in cellular growth and survival. The EGFR is also vital for normal placental ...
Impact of new criteria for the diagnosis of gestational diabetes: a maternal and neonatal health outcome and economic analysis in a large tertiary level maternity centre
Background: The development of diabetes mellitus during pregnancy, referred to as gestational diabetes (GDM), is associated with adverse maternal and fetal outcomes. Routine screening for this condition is therefore ...
Cancer stem cell-associated pathways regulating chemoresistance in ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal of the gynaecologic malignancies, with an overall 5-year survival rate of only <30%. This poor prognosis is due to the advanced-stage disease at initial diagnosis in ...
Novel technology for the measurement of newborn and infant heart rate
Background: Monitoring heart rate in newborns and infants is crucially important in guiding resuscitation and medical care. Established methods for heart rate assessment of these children have inherent drawbacks. In recent ...
Nasal high flow as primary respiratory support for preterm infants
Background Preterm birth is a major cause of morbidity and mortality worldwide. Respiratory distress syndrome is an important complication of preterm birth, and there is increasing evidence that ‘non-invasive’ respiratory ...
Developing novel therapeutics for preeclampsia
Preeclampsia complicates 5-8% of pregnancies and is responsible for 60,000 maternal deaths and far greater numbers of perinatal deaths annually. Disappointingly these statistics have remained static over the last 50 years, ...
Characterisation of maternal pre-eclampsia susceptibility genes
Introduction: Pre-eclampsia (PE) has affected pregnant women throughout human history and remains a leading cause of maternal and fetal mortality and morbidity worldwide today. PE is clinically characterised by de novo ...
The role of embryonic stem cell factor Oct4A in epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is the most lethal of all the gynaecological malignancies with a five year mortality rate of >70%. The majority of EOC cases are diagnosed at advanced metastatic stages. Here, the disease ...
The role of placental heparan sulphate proteoglycans in the pathogenesis of pre-eclampsia
Introduction: Uncomplicated pregnancies represent a hypercoaguable state. However, placental thrombosis is rare in these pregnancies which suggests that thrombin generation must be tightly regulated. In contrast, pregnancy ...
Optimizing synchrotron microbeam radiotherapy for cancer treatment
Synchrotron microbeam radiation therapy (MRT) is a novel, preclinical form of treatment that has proven effective at ablating tumours in a range of animal models, with significantly reduced damage to adjacent normal tissues. ...