Models of spontaneous intracerebral haemorrhage in hypertensive rats

Abstract

Few animal models of stroke have created haematomas that mimic the processes seen in humans. We developed a new model of intracerebral haemorrhage (ICH) in rats by inducing acute-on-chronic hypertension that more closely mimics the human condition than existing models. We also examined profiles of ICH development in the genetically hypertensive Spontaneously Hypertensive Rat and in normotensive rats made hypertensive by induction of renal disease via renal artery obstruction or kidney resection.