Models of spontaneous intracerebral haemorrhage in hypertensive rats
AffiliationFlorey Department of Neuroscience and Mental Health
Document TypePhD thesis
Access StatusThis item is embargoed and will be available on 2020-04-16.
© 2017 Dr Charlotte Krenus
Few animal models of stroke have created haematomas that mimic the processes seen in humans. We developed a new model of intracerebral haemorrhage (ICH) in rats by inducing acute-on-chronic hypertension that more closely mimics the human condition than existing models. We also examined profiles of ICH development in the genetically hypertensive Spontaneously Hypertensive Rat and in normotensive rats made hypertensive by induction of renal disease via renal artery obstruction or kidney resection.
Keywordsintracerebral haemorrhage; stroke; hypertension; animal model; translation
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