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dc.contributor.authorvan der Walt, A
dc.contributor.authorKolbe, S
dc.contributor.authorMitchell, P
dc.contributor.authorWang, Y
dc.contributor.authorButzkueven, H
dc.contributor.authorEgan, G
dc.contributor.authorYiannikas, C
dc.contributor.authorGraham, S
dc.contributor.authorKilpatrick, T
dc.contributor.authorKlistorner, A
dc.date.available2018-04-16T22:32:26Z
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.available2015-01-28
dc.date.issued2015-05-28
dc.identifierpii: PONE-D-14-44917
dc.identifier.citationvan der Walt, A., Kolbe, S., Mitchell, P., Wang, Y., Butzkueven, H., Egan, G., Yiannikas, C., Graham, S., Kilpatrick, T. & Klistorner, A. (2015). Parallel Changes in Structural and Functional Measures of Optic Nerve Myelination after Optic Neuritis. PLOS ONE, 10 (5), https://doi.org/10.1371/journal.pone.0121084.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/210731
dc.description.abstractINTRODUCTION: Visual evoked potential (VEP) latency prolongation and optic nerve lesion length after acute optic neuritis (ON) corresponds to the degree of demyelination, while subsequent recovery of latency may represent optic nerve remyelination. We aimed to investigate the relationship between multifocal VEP (mfVEP) latency and optic nerve lesion length after acute ON. METHODS: Thirty acute ON patients were studied at 1, 3, 6 and 12 months using mfVEP and at 1 and 12 months with optic nerve MRI. LogMAR and low contrast visual acuity were documented. By one month, the mfVEP amplitude had recovered sufficiently for latency to be measured in 23 (76.7%) patients with seven patients having no recordable mfVEP in more than 66% of segments in at least one test. Only data from these 23 patients was analysed further. RESULTS: Both latency and lesion length showed significant recovery during the follow-up period. Lesion length and mfVEP latency were highly correlated at 1 (r = 0.94, p = <0.0001) and 12 months (r = 0.75, p < 0.001). Both measures demonstrated a similar trend of recovery. Speed of latency recovery was faster in the early follow-up period while lesion length shortening remained relatively constant. At 1 month, latency delay was worse by 1.76 ms for additional 1mm of lesion length while at 12 months, 1mm of lesion length accounted for 1.94 ms of latency delay. CONCLUSION: A strong association between two putative measures of demyelination in early and chronic ON was found. Parallel recovery of both measures could reflect optic nerve remyelination.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.titleParallel Changes in Structural and Functional Measures of Optic Nerve Myelination after Optic Neuritis
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0121084
melbourne.affiliation.departmentMedicine, Dentistry & Health Sciences
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.affiliation.departmentCentre for Neuroscience
melbourne.source.titlePLOS ONE
melbourne.source.volume10
melbourne.source.issue5
dc.rights.licenseCC BY
melbourne.elementsid979950
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447428
melbourne.contributor.authorKolbe, Scott
melbourne.contributor.authorEgan, Gary
melbourne.contributor.authorButzkueven, Helmut
melbourne.contributor.authorvan der Walt, Anneke
melbourne.contributor.authorKilpatrick, Trevor
melbourne.contributor.authorWANG, YEJUN
melbourne.contributor.authorMitchell, Peter
dc.identifier.eissn1932-6203
pubs.acceptance.date2015-01-28
melbourne.accessrightsOpen Access


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