Medicine (Austin & Northern Health) - Theses
Now showing items 1-10 of 129
Understanding the molecular basis for response and resistance to targeted therapies in colorectal cancer
Active treatment options for patients with metastatic colorectal cancer (CRC) have evolved significantly over the last 20 years. During this time, the median overall survival of these patients has approximately doubled. ...
Clinical Studies in HFE haemochromatosis
HFE haemochromatosis is the most common iron overload disease. Since the discovery of the HFE gene is 1996, it is readily diagnosed using a genetic test rather than using liver biopsies. It is an autosomal recessive disease ...
Use of copy number variation polymorphism to assess cellular and cell-free DNA chimerism following transplantation
A state of genetic chimerism is created by allogenic transplantation, the quality and quantity of which may have diagnostic significance. The monitoring of cellular macrochimerism following allogeneic hematopoietic cell ...
Health consequences for mother and baby of substantial pre-conception weight loss in women with obesity
Obesity in women of child-bearing age is common. There is little evidence that modest weight loss using lifestyle modification alters pregnancy outcomes. Bariatric surgery results in substantial weight loss, which reduces ...
The AGE/RAGE pathway in NAFLD progression to liver fibrosis: targets for prevention and treatment
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in Australia and around the world and affects up to 40% of the adult population. It is the leading cause for liver transplantation in the USA ...
Identification and removal of unwanted variation in large gene expression data
Gene expression experiments are conducted to better understand the biological mechanisms in cells and tissues. Examples of the wide range of research and clinical applications of gene expression analysis include: identifying ...
Oxygen therapy in interstitial lung disease
The interstitial lung diseases (ILD) are a diverse group of inflammatory and fibrotic lung conditions which cause significant morbidity and mortality. The prototypic ILD, idiopathic pulmonary fibrosis, is the most common ...
Therapeutic potential of targeting the protective arm of the renin angiotensin system in cirrhotic and non-cirrhotic portal hypertension
Portal hypertension (PHT) and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in cirrhotic patients. In cirrhotics, splanchnic vasodilatation leading to an elevated portal venous inflow ...
T cell immunity to cytomegalovirus in health, transplantation and novel vaccines
Cytomegalovirus (CMV) infects the majority of the world’s population and establishes a life-long infection, which requires intact T cell responses to control. Infants in utero and immune-compromised populations are most ...
The use of humidified, warmed CO2 in cancer surgery to improve patient outcomes
Aim To investigate the effects of warmed, humidified CO2 on peritoneal inflammation and tissue damage, tumor microenvironment, and perioperative outcomes in colorectal cancer surgery. Methods • A literature review ...