Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
AuthorWilliamson, AE; Ylioja, PM; Robertson, MN; Antonova-Koch, Y; Avery, V; Baell, JB; Batchu, H; Batra, S; Burrows, JN; Bhattacharyya, S; ...
Source TitleACS CENTRAL SCIENCE
PublisherAMER CHEMICAL SOC
AffiliationBiochemistry and Molecular Biology
School of Chemistry
Document TypeJournal Article
CitationsWilliamson, AE; Ylioja, PM; Robertson, MN; Antonova-Koch, Y; Avery, V; Baell, JB; Batchu, H; Batra, S; Burrows, JN; Bhattacharyya, S; Calderon, F; Charman, SA; Clark, J; Crespo, B; Dean, M; Debbert, SL; Delves, M; Dennis, ASM; Deroose, F; Duffy, S; Fletcher, S; Giaever, G; Hallyburton, I; Gamo, F-J; Gebbia, M; Guy, RK; Hungerford, Z; Kirk, K; Lafuente-Monasterio, MJ; Lee, A; Meister, S; Nislow, C; Overington, JP; Papadatos, G; Patiny, L; Pham, J; Ralph, SA; Ruecker, A; Ryan, E; Southan, C; Srivastava, K; Swain, C; Tarnowski, MJ; Thomson, P; Turner, P; Wallace, IM; Wells, TNC; White, K; White, L; Willis, P; Winzeler, EA; Wittlin, S; Todd, MH, Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles, ACS CENTRAL SCIENCE, 2016, 2 (10), pp. 687 - 701
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084075
The development of new antimalarial compounds remains a pivotal part of the strategy for malaria elimination. Recent large-scale phenotypic screens have provided a wealth of potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to participate, and patents were not sought. One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change. A second subseries displayed high potency, including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by the community; new findings may be cumulatively added to the present work.
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