• Investigating the p53-independent responses to inhibition of RNA Polymerase I transcription by CX-5461 

  Quin, Jaclyn (2017)

  Increased rates of DNA-dependent RNA Polymerase I (Pol I) transcription of the 47S pre-ribosomal RNA (rRNA) genes are observed in almost all cancer types. Cancer cells may require high rates of Pol I transcription and ...

• Mechanisms of inclusion assembly in Huntington’s disease 

  Trubetskov, Mikhail (2017)

  Formation of microscopically visible intracellular aggregates (inclusions) containing exon 1 fragments of mutant Huntingtin (mHttex1) is a hallmark of Huntington’s Disease (HD) pathology. The role of inclusions in HD ...

• Metabolomics reveals the relationship between the host and the gut in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 

  Armstrong, Christopher William (2017)

  Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a poorly understood disorder that likely has a complex etiological mechanism entailing predisposing, triggering, and maintaining factors. ME/CFS patients present ...

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