Biochemistry and Molecular Biology

In vitro investigation of dipeptide repeat proteins in C9ORF72-associated motor neuron disease and frontotemporal dementia

Radwan Ahmed Elsayed, Mona (2020)

Mutations that expand a hexanucleotide (GGGGCC) tandem repeat sequence (HTRS) in intron-1 of the C9ORF72 gene is the major cause of familial motor neuron disease MND and frontotemporal dementia (FTD). The expanded HTRSs ...
mCSM-membrane: predicting the effects of mutations on transmembrane proteins.

Pires, DEV; Rodrigues, CHM; Ascher, DB (Oxford University Press, 2020-07-02)

Significant efforts have been invested into understanding and predicting the molecular consequences of mutations in protein coding regions, however nearly all approaches have been developed using globular, soluble proteins. ...
Cotargeting BCL-2 and MCL-1 in high-risk B-ALL

Moujalled, DM; Hanna, DT; Hediyeh-zadeh, S; Pomilio, G; Brown, L; Litalien, V; Bartolo, R; Fleming, S; Chanrion, M; Banquet, S; ... (AMER SOC HEMATOLOGY, 2020-06-23)

Improving survival outcomes in adult B-cell acute lymphoblastic leukemia (B-ALL) remains a clinical challenge. Relapsed disease has a poor prognosis despite the use of tyrosine kinase inhibitors (TKIs) for Philadelphia ...