Biochemistry and Molecular Biology
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Discovering inhibitors of cell surface receptor function as the basis for novel therapeutics to treat cancer (2020)As our understanding of the molecular changes that trigger and potentiate cancer increases, cancer therapies are becoming increasingly refined and specifically targeted to increase efficacy and reduce side effects. ...
Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse (NATURE PUBLISHING GROUP, 2014-02-27)While the Cysteine-Rich Secretory Proteins (CRISPs) have been broadly proposed as regulators of reproduction and immunity, physiological roles have yet to be established for individual members of this family. Past efforts ...
Increased metal content in the TDP-43(A315T) transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (FRONTIERS RESEARCH FOUNDATION, 2014-02-11)Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is recapitulated in mouse models of Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and neuronal ...