Biochemistry and Molecular Biology
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(2018)Klebsiella pneumoniae is an opportunistic pathogen and global cause of hospital-associated (HA) infections. K. pneumoniae is also part of the healthy human microbiome, providing a potential reservoir for infection. However, ...
Molecular mechanisms of artemisinin action and resistance in the malaria parasite Plasmodium falciparum (2018)Malaria is the disease caused by infection of red blood cells with the protozoan parasite, Plasmodium. In 2016 alone, 216 million people suffered from malaria, leading to 445 000 deaths. Artemisinin-based combination ...
Investigating the p53-independent responses to inhibition of RNA Polymerase I transcription by CX-5461 (2017)Increased rates of DNA-dependent RNA Polymerase I (Pol I) transcription of the 47S pre-ribosomal RNA (rRNA) genes are observed in almost all cancer types. Cancer cells may require high rates of Pol I transcription and ...