Biochemistry and Molecular Biology - Research Publications
Now showing items 1-10 of 439
Interferon regulatory factor 5 and autoimmune lupus
(CAMBRIDGE UNIV PRESS, 2013-07-27)
Systemic lupus erythematosus (SLE) is a severe multi-system autoimmune disease, whereas interferon regulatory factor (IRF) 5 belongs to the family of transcription factors that modulate immune system activities. Recently, ...
Interaction of Rabies Virus P-Protein With STAT Proteins is Critical to Lethal Rabies Disease
(OXFORD UNIV PRESS INC, 2014-06-27)
Background. Rabies virus (RABV) causes rabies disease resulting in >55 000 human deaths/year. The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins ...
C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to alpha-cleavage
(PORTLAND PRESS LTD, 2014-04-27)
Misfolding of PrPC (cellular prion protein) to beta-strand-rich conformations constitutes a key event in. prion disease pathogenesis. PrPC can undergo either of two constitutive endoproteolytic events known as alpha- and ...
A dual-targeted aminoacyl-tRNA synthetase in Plasmodium falciparum charges cytosolic and apicoplast tRNA(Cys)
(PORTLAND PRESS LTD, 2014-03-27)
Plasmodium parasites possess two endosymbiotic organelles: a mitochondrion and a relict plastid called the apicoplast. To accommodate the translational requirements of these organelles in addition to its cytosolic translation ...
cAMP-dependent Protein Kinase and c-Jun N-terminal Kinase Mediate Stathmin Phosphorylation for the Maintenance of Interphase Microtubules during Osmotic Stress
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2014-01-27)
Dynamic microtubule changes after a cell stress challenge are required for cell survival and adaptation. Stathmin (STMN), a cytoplasmic microtubule-destabilizing phosphoprotein, regulates interphase microtubules during ...
Global Phylogeny of Shigella sonnei Strains from Limited Single Nucleotide Polymorphisms (SNPs) and Development of a Rapid and Cost-Effective SNP-Typing Scheme for Strain Identification by High-Resolution Melting Analysis
(AMER SOC MICROBIOLOGY, 2013-01-27)
The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms ...
A biosensor of Src family kinase conformation by exposable tetracysteine useful for cell-based screening
(American Chemical Society (ACS), 2014)
We developed a new approach to distinguish distinct protein conformations in live cells. The method, exposable tetracysteine (XTC), involved placing an engineered tetracysteine motif into a target protein that has conditional ...
Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1)
Mutations of the phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) gene can cause early-onset familial Parkinson disease (PD). PINK1 encodes a neuroprotective protein kinase localized at the mitochondria, and ...
Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of Leucine-rich repeat kinase 2 (LRRK2)
Genetic variations of leucine-rich repeat kinase 2 (LRRK2) are the major cause of dominantly inherited Parkinson disease (PD). LRRK2 protein contains seven predicted domains: a tandem Ras-like GTPase (ROC) domain and ...