Biochemistry and Molecular Biology - Theses
Now showing items 1-10 of 137
Anterograde sorting and trafficking of the β-amyloid precursor protein and β-Secretase in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the extracellular deposition of amyloid plaques in the brain. Amyloid plaques are derived from the aggregation of pathogenic β-amyloid (Aβ) peptide, which is generated from the ...
Investigating acquired resistance to Pol I transcription inhibitors for the treatment of haematologic malignancies
Previous work from our group and others has demonstrated that CX-5461 (Senhwa Biosciences), a first-in-class small molecule inhibitor of RNA Polymerase I transcription of the ribosomal RNA genes, is effective at treating ...
Structural basis of the interaction between the C-terminal domain of rabies virus phosphoprotein and human STAT1
The archetype rabies virus belongs to the genus lyssavirus which collectively are the causative agents of rabies disease. The deadly disease has a 100% case-fatality rate in humans, killing over 61,000 people a year and ...
Population structure and carriage-infection dynamics of Klebsiella pneumoniae
Klebsiella pneumoniae is an opportunistic pathogen and global cause of hospital-associated (HA) infections. K. pneumoniae is also part of the healthy human microbiome, providing a potential reservoir for infection. However, ...
The role of de novo myo-inositol synthesis and matabolism in Leishmania parasites
Leishmania are protozoan parasites responsible for a spectrum of sandfly-borne diseases known as the leishmaniases that cause substantial morbidity and mortality in some of the most impoverished countries in the world. ...
Molecular mechanisms of artemisinin action and resistance in the malaria parasite Plasmodium falciparum
Malaria is the disease caused by infection of red blood cells with the protozoan parasite, Plasmodium. In 2016 alone, 216 million people suffered from malaria, leading to 445 000 deaths. Artemisinin-based combination ...
Investigating the p53-independent responses to inhibition of RNA Polymerase I transcription by CX-5461
Increased rates of DNA-dependent RNA Polymerase I (Pol I) transcription of the 47S pre-ribosomal RNA (rRNA) genes are observed in almost all cancer types. Cancer cells may require high rates of Pol I transcription and ...
Mechanism of action of the potential tumour suppressor Csk homologous kinase (Chk) in colorectal cancer cells
Aberrant activation of Src family tyrosine kinases (SFKs) directs initiation of metastasis and development of drug resistance in multiple solid tumours and haematological cancers. Intriguingly, 80% of colorectal cancer ...
Human T-lymphotropic virus type-1: molecular characterization of HTLV-1 subtype C and the role of proviral load in pathogenesis in a remote Indigenous Australian setting
In Central Australia, a strain of HTLV-1 genetically different from other HTLV-1 clades is highly endemic in remote Indigenous communities, yet much remains unknown regarding HTLV-1 disease pathogenesis and why certain ...
Probing the immunopeptidome: enhanced epitope discovery through sHLA technology and bioinformatics
Human leukocyte antigen (HLA) molecules are cell-surface glycoproteins that present peptides, derived from diverse protein antigens, for surveillance by T lymphocytes. This immunosurveillance seeks signs of disease or ...