Biochemistry and Molecular Biology - Theses
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Assembly of the Plasmodium falciparum virulence complex
After invading a human red blood cell (RBC), Plasmodium falciparum modifies the host RBC surface by exporting proteins that traffic to and interact with the RBC membrane skeleton. The physical properties of the RBC are ...
Towards the development of fucosyltransferase 8 inhibitors
Glycosyltransferases (GTs) biosynthesise glycoconjugates and thus play a central role in regulating the abundance and biological functions of these diverse biomacromolecules. This is most evident in cancer cells, where ...
Structural analysis of critical interactions in the replication machinery of rabies virus
Rabies virus is a non-segmented negative sense RNA virus that causes encephalitis in humans with a 100% case fatality rate, resulting in > 61,000 deaths/year world-wide. There are currently no treatments for rabies disease, ...
The impact of proteostasis imbalance on proteome solubility
A hallmark of neurodegenerative diseases is that certain proteins abnormally aggregate into insoluble deposits. A leading hypothesis is that a breakdown in protein folding quality control mechanisms leads to the accumulation ...
Impact of respiratory syncytial virus infection on host mitochondrial organisation and function
Respiratory syncytial virus (RSV), a leading cause of acute lower respiratory illness in infants, immunosuppressed adults and the elderly, is responsible for more deaths each year than influenza. Despite this, there are ...
Biochemical mechanisms of biomineralization and elemental incorporation in otoliths: implications for fish and fisheries research
All vertebrates have small bioinorganic “earstones” in their inner ear labyrinth that are essential for hearing and balance. While otoliths play a vital anatomical role in fish, their true value to science is as biochronometers, ...
New pathogenic mechanisms in SCA1 neurodegenerative disease revealed by the ataxin-1 interactome
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease in which a marked atrophy of neurons in the cerebellum and brainstem causes coordination and movement disabilities and ultimately death ...
Understanding biological signalling in the βc cytokine receptor family
The beta-common ( βc) family of cytokines, namely granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5, are modulators of cell survival, differentiation and proliferation during normal and ...
Characterisation of the human TIM22 mitochondrial import translocase
Mitochondria are essential cellular organelles for cell viability due to their fundamental role in ATP production, programmed cell death and biosynthetic pathways. Dysfunctional mitochondria are implicated in various ...
Regulation of MHC class II ubiquitination in antigen presenting cells