Biochemistry and Molecular Biology - Theses
Now showing items 1-10 of 140
Characterisation of the human TIM22 mitochondrial import translocase
Mitochondria are essential cellular organelles for cell viability due to their fundamental role in ATP production, programmed cell death and biosynthetic pathways. Dysfunctional mitochondria are implicated in various ...
Regulation of MHC class II ubiquitination in antigen presenting cells
Major histocompatibility complex class II (MHC II) proteins on the surface of antigen presenting cells are crucial for the development and activation of CD4+ T cells. In dendritic cells (DCs) and B cells, MHC II levels are ...
Transcriptional regulation and functional differences driven by STAT3 isoforms, STAT3α and STAT3β
The Signal transducer and activator of transcription 3 (STAT3) protein, a member of the STAT family of transcription factors, plays important roles in the regulation of critical biological processes. STAT3 is best known ...
Anterograde sorting and trafficking of the β-amyloid precursor protein and β-Secretase in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the extracellular deposition of amyloid plaques in the brain. Amyloid plaques are derived from the aggregation of pathogenic β-amyloid (Aβ) peptide, which is generated from the ...
Investigating acquired resistance to Pol I transcription inhibitors for the treatment of haematologic malignancies
Previous work from our group and others has demonstrated that CX-5461 (Senhwa Biosciences), a first-in-class small molecule inhibitor of RNA Polymerase I transcription of the ribosomal RNA genes, is effective at treating ...
Structural basis of the interaction between the C-terminal domain of rabies virus phosphoprotein and human STAT1
The archetype rabies virus belongs to the genus lyssavirus which collectively are the causative agents of rabies disease. The deadly disease has a 100% case-fatality rate in humans, killing over 61,000 people a year and ...
Population structure and carriage-infection dynamics of Klebsiella pneumoniae
Klebsiella pneumoniae is an opportunistic pathogen and global cause of hospital-associated (HA) infections. K. pneumoniae is also part of the healthy human microbiome, providing a potential reservoir for infection. However, ...
The role of de novo myo-inositol synthesis and matabolism in Leishmania parasites
Leishmania are protozoan parasites responsible for a spectrum of sandfly-borne diseases known as the leishmaniases that cause substantial morbidity and mortality in some of the most impoverished countries in the world. ...
Molecular mechanisms of artemisinin action and resistance in the malaria parasite Plasmodium falciparum
Malaria is the disease caused by infection of red blood cells with the protozoan parasite, Plasmodium. In 2016 alone, 216 million people suffered from malaria, leading to 445 000 deaths. Artemisinin-based combination ...
Investigating the p53-independent responses to inhibition of RNA Polymerase I transcription by CX-5461
Increased rates of DNA-dependent RNA Polymerase I (Pol I) transcription of the 47S pre-ribosomal RNA (rRNA) genes are observed in almost all cancer types. Cancer cells may require high rates of Pol I transcription and ...