Biochemistry and Molecular Biology - Theses
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Impact of respiratory syncytial virus infection on host mitochondrial organisation and function
Respiratory syncytial virus (RSV), a leading cause of acute lower respiratory illness in infants, immunosuppressed adults and the elderly, is responsible for more deaths each year than influenza. Despite this, there are ...
Biochemical mechanisms of biomineralization and elemental incorporation in otoliths: implications for fish and fisheries research
All vertebrates have small bioinorganic “earstones” in their inner ear labyrinth that are essential for hearing and balance. While otoliths play a vital anatomical role in fish, their true value to science is as biochronometers, ...
New pathogenic mechanisms in SCA1 neurodegenerative disease revealed by the ataxin-1 interactome
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease in which a marked atrophy of neurons in the cerebellum and brainstem causes coordination and movement disabilities and ultimately death ...
Understanding biological signalling in the βc cytokine receptor family
The beta-common ( βc) family of cytokines, namely granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5, are modulators of cell survival, differentiation and proliferation during normal and ...
Characterisation of the human TIM22 mitochondrial import translocase
Mitochondria are essential cellular organelles for cell viability due to their fundamental role in ATP production, programmed cell death and biosynthetic pathways. Dysfunctional mitochondria are implicated in various ...
Regulation of MHC class II ubiquitination in antigen presenting cells
Transcriptional regulation and functional differences driven by STAT3 isoforms, STAT3α and STAT3β
The Signal transducer and activator of transcription 3 (STAT3) protein, a member of the STAT family of transcription factors, plays important roles in the regulation of critical biological processes. STAT3 is best known ...
Anterograde sorting and trafficking of the β-amyloid precursor protein and β-Secretase in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the extracellular deposition of amyloid plaques in the brain. Amyloid plaques are derived from the aggregation of pathogenic β-amyloid (Aβ) peptide, which is generated from the ...
Investigating acquired resistance to Pol I transcription inhibitors for the treatment of haematologic malignancies
Previous work from our group and others has demonstrated that CX-5461 (Senhwa Biosciences), a first-in-class small molecule inhibitor of RNA Polymerase I transcription of the ribosomal RNA genes, is effective at treating ...
Structural basis of the interaction between the C-terminal domain of rabies virus phosphoprotein and human STAT1
The archetype rabies virus belongs to the genus lyssavirus which collectively are the causative agents of rabies disease. The deadly disease has a 100% case-fatality rate in humans, killing over 61,000 people a year and ...