Biochemistry and Molecular Biology - Theses
Now showing items 1-10 of 153
Mechanism of activation of the relaxin family peptide receptors RXFP1 and RXFP2
The relaxin family peptide receptors RXFP1 and RXFP2 are the cognate receptors for the peptide hormones relaxin and INSL3 respectively, best known for their roles in reproductive biology. Being GPCRs, these receptors are ...
Determination of ligand binding conformations at α1-adrenergic receptor subtypes based on NMR and MD studies
Adrenergic receptor (AR) subtypes (α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3) are G-protein coupled receptors (GPCRs) activated by the same endogenous catecholamines, adrenaline and nor-adrenaline. The two subtypes α1A- and ...
Determining the role of doublecortin X (DCX) in cytoskeleton organisation
X-linked Doublecortin (DCX) is a 40 kDa neuron-specific microtubule (MT)-associated protein. The initial identification of inheritable dcx gene mutations and their disruption of cortical layering and brain development in ...
Detecting horizontal co-transfer of antimicrobial resistance genes in bacteria: a network approach
Antimicrobials have been widely using as a major resource to treat bacterial infections for almost a century. However, it is not unusual to see antimicrobial resistance emerges in a bacterial species due to natural selection ...
Assembly of the Plasmodium falciparum virulence complex
After invading a human red blood cell (RBC), Plasmodium falciparum modifies the host RBC surface by exporting proteins that traffic to and interact with the RBC membrane skeleton. The physical properties of the RBC are ...
Towards the development of fucosyltransferase 8 inhibitors
Glycosyltransferases (GTs) biosynthesise glycoconjugates and thus play a central role in regulating the abundance and biological functions of these diverse biomacromolecules. This is most evident in cancer cells, where ...
Structural analysis of critical interactions in the replication machinery of rabies virus
Rabies virus is a non-segmented negative sense RNA virus that causes encephalitis in humans with a 100% case fatality rate, resulting in > 61,000 deaths/year world-wide. There are currently no treatments for rabies disease, ...
The impact of proteostasis imbalance on proteome solubility
A hallmark of neurodegenerative diseases is that certain proteins abnormally aggregate into insoluble deposits. A leading hypothesis is that a breakdown in protein folding quality control mechanisms leads to the accumulation ...
Impact of respiratory syncytial virus infection on host mitochondrial organisation and function
Respiratory syncytial virus (RSV), a leading cause of acute lower respiratory illness in infants, immunosuppressed adults and the elderly, is responsible for more deaths each year than influenza. Despite this, there are ...
Biochemical mechanisms of biomineralization and elemental incorporation in otoliths: implications for fish and fisheries research
All vertebrates have small bioinorganic “earstones” in their inner ear labyrinth that are essential for hearing and balance. While otoliths play a vital anatomical role in fish, their true value to science is as biochronometers, ...