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Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes

Pane, JA; Webster, NL; Graham, KL; Holloway, G; Zufferey, C; Coulson, BS (SPRINGER, 2013-03-01)

AIMS/HYPOTHESIS: Rotavirus infection in at-risk children correlates with production of serum autoantibodies indicative of type 1 diabetes progression. Oral infection with rhesus monkey rotavirus (RRV) accelerates diabetes ...

Understanding CD8(+) T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope

Nguyen, THO; Tan, ACL; Xiang, SD; Goubier, A; Harland, KL; Clemens, EB; Plebanski, M; Kedzierska, K (WILEY, 2017-03-17)

The Wilms' tumor 1 (WT1) antigen is expressed in solid and hematological malignancies, but not healthy tissues, making it a promising target for cancer immunotherapies. Immunodominant WT1 epitopes, the native HLA-A2/WT1126-134 ...

MHC class I expression in intestinal cells is reduced by rotavirus infection and increased in bystander cells lacking rotavirus antigen

Holloway, G; Fleming, FE; Coulson, BS (NATURE PUBLISHING GROUP, 2018-01-08)

Detection of viral infection by host cells leads to secretion of type I interferon, which induces antiviral gene expression. The class I major histocompatibility complex (MHCI) is required for viral antigen presentation ...

CD8(+) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria

Lau, LS; Fernandez-Ruiz, D; Mollard, V; Sturm, A; Neller, MA; Cozijnsen, A; Gregory, JL; Davey, GM; Jones, CM; Lin, Y-H; ... (PUBLIC LIBRARY SCIENCE, 2014-05-01)

To follow the fate of CD8+ T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR transgenic mouse line against this pathogen. T cells from this line, termed PbT-I T cells, were ...