University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Melbourne Medical School Collected Works
  • Melbourne Medical School Collected Works - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Melbourne Medical School Collected Works
  • Melbourne Medical School Collected Works - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    The role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing

    Thumbnail
    Download
    Accepted version (696.8Kb)

    Citations
    Scopus
    Web of Science
    Altmetric
    6
    4
    Author
    Zhang, L; Miramini, S; Richardson, M; Mendis, P; Ebeling, P
    Date
    2017-09-01
    Source Title
    AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Ebeling, Peter; Zhang, Lihai; Mendis, Priyan; Miramini, Seyedsaeed; Richardson, Martin
    Affiliation
    Melbourne Medical School
    Clinical School (Royal Melbourne Hospital)
    Infrastructure Engineering
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Zhang, L., Miramini, S., Richardson, M., Mendis, P. & Ebeling, P. (2017). The role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing. AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE, 40 (3), pp.603-610. https://doi.org/10.1007/s13246-017-0566-y.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/217909
    DOI
    10.1007/s13246-017-0566-y
    Abstract
    With demographic change and increasing life expectancy, osteoporotic fractures have become one of the most prevalent trauma conditions seen in daily clinical practice. A variety of factors are known to affect the rate of healing in osteoporotic conditions (e.g. both biochemical and biomechanical environment of callus cells). However, the influence of impairment of mesenchymal stem cell function in the osteoporotic condition on bone fracture healing has not been fully understood. In the present study, we develop a mathematical model that quantifies the change in biological processes within the fracture callus as a result of osteoporosis. The model includes special features of osteoporosis such as reduction in mesenchymal stem cell (MSC) number in osteoporotic bone, impaired response of osteoporotic MSCs to their biomechanical microenvironment and the effects of configuration of locking compression plate (LCP) system on healing in this context. The results presented here suggest that mechanically-mediated MSCs differentiation at early stages of healing are significantly affected under osteoporotic conditions, while it is predicted that the flexible fixation achieved by increasing bone-plate distance of LCP could alleviate the negative effects of osteoporosis on healing. The outcomes of this study could potentially lead to patient specific surgical solutions, and thus achieve optimal healing outcomes in osteoporotic conditions.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Melbourne Medical School Collected Works - Research Publications [451]
    • Clinical School (Royal Melbourne Hospital) - Research Publications [16]
    • Infrastructure Engineering - Research Publications [1240]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors