Characterising the ocular phenotype in a murine model of Alzheimer’s disease
AffiliationOptometry and Vision Sciences
Document TypePhD thesis
Access StatusThis item is embargoed and will be available on 2020-11-15.
© 2018 Dr. Jeremiah Lim
This thesis shows that amyloid beta found in the brain is also present in the retina of a murine model of Alzheimer’s disease. By applying non-invasive retinal techniques, we show that neuronal structural and functional changes occur early in this model and that these are associated with vascular dysfunction. Such retinal hallmarks differentiate Alzheimer's changes from healthy ageing mice and provide evidence that the retina is a viable biomarker for dementia.
KeywordsAlzheimer's disease; retina; 5xFAD; neurodegeneration; electroretinography; optical coherence tomography; amyloid beta; dementia
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