Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function
AuthorEkinci, EI; Jerums, G; Skene, A; Crammer, P; Power, D; Cheong, KY; Panagiotopoulos, S; McNeil, K; Baker, ST; Fioretto, P; ...
Source TitleDiabetes Care
PublisherAMER DIABETES ASSOC
University of Melbourne Author/sEkinci, Elif; Jerums, George; Power, David; Panagiotopoulos, Sianna; MacIsaac, Richard; Cheong, Karey; MCNEIL, KAREN; BAKER, SCOTT
AffiliationCentre for Cancer Research
Medicine, Dentistry & Health Sciences
Clinical School (Austin Health)
Medicine (Austin & Northern Health)
Medicine (St Vincent's)
Document TypeJournal Article
CitationsEkinci, E. I., Jerums, G., Skene, A., Crammer, P., Power, D., Cheong, K. Y., Panagiotopoulos, S., McNeil, K., Baker, S. T., Fioretto, P. & MacIsaac, R. J. (2013). Renal Structure in Normoalbuminuric and Albuminuric Patients With Type 2 Diabetes and Impaired Renal Function. DIABETES CARE, 36 (11), pp.3620-3626. https://doi.org/10.2337/dc12-2572.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816854
OBJECTIVE: The structural basis of normoalbuminuric renal insufficiency in patients with type 2 diabetes remains to be elucidated. We compared renal biopsy findings in patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) and measured GFR of <60 mL/min/1.73 m2, associated with either normo-, micro-, or macroalbuminuria. RESEARCH DESIGN AND METHODS: In patients with normo- (n = 8) or microalbuminuria (n = 6), renal biopsies were performed according to a research protocol. In patients with macroalbuminuria (n = 17), biopsies were performed according to clinical indication. Findings were categorized according to the Fioretto classification: category 1 (C1), normal/near normal; category 2 (C2), typical diabetic nephropathy (DN) with predominantly glomerular changes; and category 3 (C3), atypical with disproportionately severe interstitial/tubular/vascular damage and with no/mild diabetic glomerular changes. RESULTS: In our study population (mean eGFR 35 mL/min/1.73 m2), typical glomerular changes (C2) of DN were observed in 22 of 23 subjects with micro- or macroalbuminuria compared with 3 of 8 subjects with normoalbuminuria (P = 0.002). By contrast, predominantly interstitial or vascular changes (C3) were seen in only 1 of 23 subjects with micro- or macroalbuminuria compared with 3 of 8 normoalbuminuric subjects (P = 0.08). Mesangial area increased progressively from normal controls to patients with type 2 diabetes and normo-, micro-, and macroalbuminuria. Varying degrees of arteriosclerosis, although not necessarily the predominant pattern, were seen in seven of eight subjects with normoalbuminuria. CONCLUSIONS: Typical renal structural changes of DN were observed in patients with type 2 diabetes and elevated albuminuria. By contrast, in normoalbuminuric renal insufficiency, these changes were seen less frequently, likely reflecting greater contributions from aging, hypertension, and arteriosclerosis.
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Publisher licenceCC BY-NC-ND
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