Melbourne Medical School Collected Works - Theses
Now showing items 1-10 of 19
The role of Dlk1 in haematopoiesis, leukaemia and angiogenesis
Delta-Like Homologue 1 (DLK1), also known as Preadipocyte Factor 1 (PREF-1), is a non-canonical EGF-like NOTCH ligand. It is maternally imprinted at the Dlk1-Dio3 imprinted locus, and has been shown to regulate embryonic ...
Targeting cyclin-dependent kinase 9 and myeloid cell leukaemia 1 in MYC-driven B-cell lymphoma
Aggressive B-cell lymphomas include diffuse large B-cell lymphoma, Burkitt lymphoma and intermediate forms. Despite high response rates to conventional immuno-chemotherapeutic approaches, an unmet need for novel therapeutic ...
Exploring the qualities of Electronic Health Record medical student documentation
Written communication within the health professions has been rapidly changing over the last decade. Implementation of Electronic Health Records (EHR) in health services is now widespread. Medical student teaching and ...
Linguistic change in an online support group
Online support groups (OSGs) are popular sources of both health information and social support. Though early research into OSGs highlighted a concern that non-expert members may give harmful advice, more recent studies ...
The malaria vaccine candidate Apical Membrane Antigen 1 – antigenic diversity and its potential as effective multi-allele vaccine
Understanding naturally acquired immunity to malaria and how human antibodies protect against clinical malaria is essential for vaccine development. Antibodies against Plasmodium falciparum apical membrane antigen 1 (AMA1), ...
Improving epigenetic therapies for haematological malignancies
The work presented here is the product of several years of clinical trial and laboratory endeavour focused on the theme of understanding and improving currently available epigenetic therapies for blood cancers, and ...
Acupuncture for menopausal hot flushes: an individually randomised sham-controlled trial
Menopausal hot flushes affect up to 90% of women and pose a significant health and financial burden. Many women are reluctant to use hormone replacement therapy, an effective treatment, because of fear of serious adverse ...
Communication performance in the career medical interview: a new model for preparation
The career medical interview is rare in that it is a central discriminator for aspirant doctors and trainees. Not only does the outcome determine the future job prospects for the candidate, but it also decides access to ...
What is the clinical placement experience of prevocational doctors in Victorian health services compared with the defined curriculum, and how may this have been shaped by contemporary healthcare delivery?
Medical training in Australia and comparable countries internationally is based on an apprenticeship model of training. However this has been challenged by contemporary healthcare practices as well as the limited training ...
Exploring the use of eLearning resources and preparedness of medical students transitioning to hospital internship
The increasing use of online technology in medical education and junior doctor training raises questions about the efficacy of this approach to improve the preparedness of medical students transitioning to internship. This ...