Local microvascular reactivity in the regulation of retinal blood flow
AffiliationOptometry and Vision Sciences
Document TypePhD thesis
Access StatusOpen Access
© 2018 Dr. Angelina Duan
Although a well-regulated blood supply is important for healthy neural function, the mechanism by which this occurs is still disputed; some studies charge this physiological response solely to the muscular arterioles, whilst others suggest capillaries are involved if not the principal co-ordinators. As this debate arises mostly from animal data, this thesis aims to determine whether the human inner retinal microvasculature, visualised in vivo using flood-illumination adaptive optics imaging, plays a role in modifying blood supply to meet metabolic demand.
Keywordsadaptive optics imaging; image processing; functional hyperaemia; flicker perturbation; gas-breathing perturbation; human retinal microvasculature; vascular reactivity
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