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dc.contributor.authorNoffs, G
dc.contributor.authorPerera, T
dc.contributor.authorKolbe, SC
dc.contributor.authorShanahan, CJ
dc.contributor.authorBoonstra, FMC
dc.contributor.authorEvans, A
dc.contributor.authorButzkueven, H
dc.contributor.authorvan der Walt, A
dc.contributor.authorVogel, AP
dc.date.available2019-03-05T10:56:40Z
dc.date.available2018-06-15
dc.date.available2018-06-15
dc.date.available2018-06-15
dc.date.available2018-06-15
dc.date.issued2018-12-01
dc.identifierpii: S1568-9972(18)30233-7
dc.identifier.citationNoffs, G., Perera, T., Kolbe, S. C., Shanahan, C. J., Boonstra, F. M. C., Evans, A., Butzkueven, H., van der Walt, A. & Vogel, A. P. (2018). What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis. AUTOIMMUNITY REVIEWS, 17 (12), pp.1202-1209. https://doi.org/10.1016/j.autrev.2018.06.010.
dc.identifier.issn1568-9972
dc.identifier.urihttp://hdl.handle.net/11343/221203
dc.description.abstractIMPORTANCE: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is frequently impaired, resulting in decreased communication skills and quality of life. Advancements in technology now makes it possible to use quantitative acoustic assessment of speech as biomarkers of disease progression. OBSERVATIONS: Four domains of speech have been identified: articulation (slow articulation and imprecise consonants), voice (pitch and loudness instability), respiration (decreased phonatory time and expiratory pressure) and prosody (longer and frequent pauses, deficient loudness control). Studies also explored I) predictive models for diagnosis of MS and of ataxia using speech variables, II) the relationship of dysarthria with cognition and III) very few studies correlated neuroimaging with dysarthria. We could not identify longitudinal studies of speech or dysarthria in Multiple Sclerosis. CONCLUSION AND RELEVANCE: Refinement of objective measures of speech has enhanced our understanding of Multiple Sclerosis-related deficits in cross-sectional analysis while both integrative and longitudinal studies are identified as major gaps. This review highlights the potential for using quantitative acoustic assessments as clinical endpoints for diagnosing, monitoring progression and treatment in disease modifying trials.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BV
dc.titleWhat speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis
dc.typeJournal Article
dc.identifier.doi10.1016/j.autrev.2018.06.010
melbourne.affiliation.departmentMedical Bionics
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentRadiology
melbourne.affiliation.departmentAudiology and Speech Pathology
melbourne.source.titleAUTOIMMUNITY REVIEWS
melbourne.source.volume17
melbourne.source.issue12
melbourne.source.pages1202-1209
melbourne.identifier.nhmrc1135683
melbourne.elementsid1351775
melbourne.contributor.authorVogel, Adam
melbourne.contributor.authorKolbe, Scott
melbourne.contributor.authorButzkueven, Helmut
melbourne.contributor.authorvan der Walt, Anneke
melbourne.contributor.authorEvans, Andrew
melbourne.contributor.authorPerera, Thushara
melbourne.contributor.authorNoffs, Gustavo
dc.identifier.eissn1873-0183
melbourne.identifier.fundernameidNHMRC, 1135683
pubs.acceptance.date2018-06-15
melbourne.accessrightsThis item is currently not available from this repository


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