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dc.contributor.authorPerera, T
dc.contributor.authorLee, W-L
dc.contributor.authorYohanandan, SAC
dc.contributor.authorAi-Lan, N
dc.contributor.authorCruse, B
dc.contributor.authorBoonstra, FMC
dc.contributor.authorNoffs, G
dc.contributor.authorVogel, AP
dc.contributor.authorKolbe, SC
dc.contributor.authorButzkueven, H
dc.contributor.authorEvans, A
dc.contributor.authorvan der Walt, A
dc.date.available2019-03-05T11:22:38Z
dc.date.available2018-09-18
dc.date.available2018-09-18
dc.date.available2018-09-18
dc.date.issued2019-01-01
dc.identifierpii: S0165-0270(18)30289-9
dc.identifier.citationPerera, T., Lee, W. -L., Yohanandan, S. A. C., Ai-Lan, N., Cruse, B., Boonstra, F. M. C., Noffs, G., Vogel, A. P., Kolbe, S. C., Butzkueven, H., Evans, A. & van der Walt, A. (2019). Validation of a precision tremor measurement system for multiple sclerosis. JOURNAL OF NEUROSCIENCE METHODS, 311, pp.377-384. https://doi.org/10.1016/j.jneumeth.2018.09.022.
dc.identifier.issn0165-0270
dc.identifier.urihttp://hdl.handle.net/11343/221205
dc.description.abstractBACKGROUND: Tremor is a debilitating symptom of Multiple Sclerosis (MS). Little is known about its pathophysiology and treatments are limited. Clinical trials investigating new interventions often rely on subjective clinical rating scales to provide supporting evidence of efficacy. NEW METHOD: We present a novel instrument (TREMBAL) which uses electromagnetic motion capture technology to quantify MS tremor. We aim to validate TREMBAL by comparison to clinical ratings using regression modelling with 310 samples of tremor captured from 13 MS participants who performed five different hand exercises during several follow-up visits. Minimum detectable change (MDC) and test-retest reliability were calculated and comparisons were made between MS tremor and data from 12 healthy volunteers. RESULTS: Velocity of the index finger was most congruent with clinical observation. Regression modelling combining different features, sensor configurations, and labelling exercises did not improve results. TREMBAL MDC was 84% of its initial measurement compared to 91% for the clinical rating. Intra-class correlations for test-retest reliability were 0.781 for TREMBAL and 0.703 for clinical ratings. Tremor was lower (p =  0.002) in healthy subjects. COMPARISON WITH EXISTING METHODS: Subjective scales have low sensitivity, suffer from ceiling effects, and mitigation against inter-rater variability is challenging. Inertial sensors are ubiquitous, however, their output is nonlinearly related to tremor frequency, compensation is required for gravitational artefacts, and their raw data cannot be intuitively comprehended. CONCLUSIONS: TREMBAL, compared with clinical ratings, gave measures in agreement with clinical observation, had marginally lower MDC, and similar test-retest reliability.
dc.languageEnglish
dc.publisherELSEVIER SCIENCE BV
dc.titleValidation of a precision tremor measurement system for multiple sclerosis
dc.typeJournal Article
dc.identifier.doi10.1016/j.jneumeth.2018.09.022
melbourne.affiliation.departmentMedical Bionics
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentRadiology
melbourne.affiliation.departmentAudiology and Speech Pathology
melbourne.source.titleJOURNAL OF NEUROSCIENCE METHODS
melbourne.source.volume311
melbourne.source.pages377-384
melbourne.elementsid1350026
melbourne.contributor.authorKolbe, Scott
melbourne.contributor.authorVogel, Adam
melbourne.contributor.authorvan der Walt, Anneke
melbourne.contributor.authorPerera, Thushara
melbourne.contributor.authorButzkueven, Helmut
melbourne.contributor.authorEvans, Andrew
melbourne.contributor.authorNguyen, Ai-Lan
dc.identifier.eissn1872-678X
pubs.acceptance.date2018-09-18
melbourne.accessrightsThis item is currently not available from this repository


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