Show simple item record

dc.contributor.authorBoonstra, FMC
dc.contributor.authorPerera, T
dc.contributor.authorNoffs, G
dc.contributor.authorMarotta, C
dc.contributor.authorVogel, AP
dc.contributor.authorEvans, AH
dc.contributor.authorButzkueven, H
dc.contributor.authorMoffat, BA
dc.contributor.authorvan der Walt, A
dc.contributor.authorKolbe, SC
dc.date.available2019-03-06T06:49:22Z
dc.date.available2018-06-11
dc.date.available2018-06-11
dc.date.available2018-06-11
dc.date.issued2018-07-02
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000436999800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4d813f4571fa7d6246bdc0dfeca3a1c
dc.identifierARTN 513
dc.identifier.citationBoonstra, F. M. C., Perera, T., Noffs, G., Marotta, C., Vogel, A. P., Evans, A. H., Butzkueven, H., Moffat, B. A., van der Walt, A. & Kolbe, S. C. (2018). Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor. FRONTIERS IN NEUROLOGY, 9 (JUL), https://doi.org/10.3389/fneur.2018.00513.
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/11343/221319
dc.description.abstractIntroduction: Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is currently without treatment. Functional MRI (fMRI) is an essential tool to investigate the pathophysiology of tremor and aid the development of treatment options. However, no adequately or standardized protocols for fMRI exists at present. Here we present a novel, online available fMRI task that could be used to assess the in vivo pathology of tremor. Objective: This study aims to validate the tremor-evoking potential of the fMRI task in a small group of tremor patients outside the scanner and assess the reproducibility of the fMRI task related activation in healthy controls. Methods: Twelve HCs were scanned at two time points (baseline and after 6-weeks). There were two runs of multi-band fMRI and the tasks included a "brick-breaker" joystick game. The game consisted of three conditions designed to control for most of the activation related to performing the task by contrasting the conditions: WATCH (look at the game without moving joystick), MOVE (rhythmic left/right movement of joystick without game), and PLAY (playing the game). Task fMRI was analyzed using FSL FEAT to determine clusters of activation during the different conditions. Maximum activation within the clusters was used to assess the ability to control for task related activation and reproducibility. Four tremor patients have been included to test ecological and construct validity of the joystick task by assessing tremor frequencies captured by the joystick. Results: In HCs the game activated areas corresponding to motor, attention and visual areas. Most areas of activation by our game showed moderate to good reproducibility (intraclass correlation coefficient (ICC) 0.531-0.906) with only inferior parietal lobe activation showing poor reproducibility (ICC 0.446). Furthermore, the joystick captured significantly more tremulous movement in tremor patients compared to HCs (p = 0.01) during PLAY, but not during MOVE. Conclusion: Validation of our novel task confirmed tremor-evoking potential and reproducibility analyses yielded acceptable results to continue further investigations into the pathophysiology of tremor. The use of this technique in studies with tremor patient will no doubt provide significant insights into the treatment options.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.titleNovel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor
dc.typeJournal Article
dc.identifier.doi10.3389/fneur.2018.00513
melbourne.affiliation.departmentMedical Bionics
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.departmentRadiology
melbourne.affiliation.departmentAudiology and Speech Pathology
melbourne.source.titleFRONTIERS IN NEUROLOGY
melbourne.source.volume9
melbourne.source.issueJUL
melbourne.identifier.nhmrc1135683
dc.rights.licenseCC BY
melbourne.elementsid1339537
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036145
melbourne.contributor.authorMoffat, Bradford
melbourne.contributor.authorPerera, Thushara
melbourne.contributor.authorVogel, Adam
melbourne.contributor.authorEvans, Andrew
melbourne.contributor.authorButzkueven, Helmut
melbourne.contributor.authorvan der Walt, Anneke
melbourne.contributor.authorKolbe, Scott
dc.identifier.eissn1664-2295
melbourne.identifier.fundernameidNHMRC, 1135683
pubs.acceptance.date2018-06-11
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record