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    Circulating osteogenic precursor cells: Building bone from blood

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    Author
    Feehan, J; Nurgali, K; Apostolopoulos, V; Al Saedi, A; Duque, G
    Date
    2019-01-01
    Source Title
    EBIOMEDICINE
    Publisher
    ELSEVIER
    University of Melbourne Author/s
    Duque, Gustavo; Apostolopoulos, Vasso; Nurgali, Kulmira; Feehan, Jack; Al Saedi, Ahmed
    Affiliation
    Medicine, Western Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Feehan, J., Nurgali, K., Apostolopoulos, V., Al Saedi, A. & Duque, G. (2019). Circulating osteogenic precursor cells: Building bone from blood. EBIOMEDICINE, 39, pp.603-611. https://doi.org/10.1016/j.ebiom.2018.11.051.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/221728
    DOI
    10.1016/j.ebiom.2018.11.051
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354620
    Abstract
    Circulating osteogenic precursor (COP) cells constitute a recently discovered population of circulating progenitor cells with the capacity to form not only bone but other mesenchymal tissues. There is a small, but growing body of literature exploring these cells, but with a great deal of disagreement and contradiction within it. This review explores the origins and biological characterization of these cells, including the identification strategies used to isolate these cells from the peripheral blood. It also examines the available knowledge on the in vitro and in vivo behaviour of these cells, in the areas of plastic adherence, differentiation capacity, proliferation, and cellular homing. We also review the implications for future use of COP cells in clinical practice, particularly in the area of regenerative medicine and the treatment and assessment of musculoskeletal disease.

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