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A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast (WILEY, 2021-05-05)To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,000 cells encompassing normal breast, preneoplastic BRCA1+/- tissue, the major breast cancer ...
Clinical outcomes after implantation of a sutureless aortic bioprosthesis with concomitant mitral valve surgery: the SURE-AVR registry (BMC, 2021-05-30)BACKGROUND: Early treatment of aortic valve stenosis is recommended in eligible symptomatic patients with severe aortic valve stenosis who would otherwise have a poor prognosis. The sutureless aortic valve bioprosthesis ...
Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images (PUBLIC LIBRARY SCIENCE, 2021-05-01)Optical Coherence Tomography (OCT) enables non-invasive imaging of the retina and is used to diagnose and manage ophthalmic diseases including glaucoma. We present the first large-scale genome-wide association study of ...