The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells
AuthorSaulep-Easton, D; Vincent, FB; Quah, PS; Wei, A; Ting, SB; Croce, CM; Tam, C; Mackay, F
PublisherNATURE PUBLISHING GROUP
AffiliationMedicine and Radiology
Microbiology and Immunology
School of Biomedical Sciences
Document TypeJournal Article
CitationsSaulep-Easton, D; Vincent, FB; Quah, PS; Wei, A; Ting, SB; Croce, CM; Tam, C; Mackay, F, The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells, LEUKEMIA, 2016, 30 (1), pp. 163 - 172
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606984
Interleukin (IL)-10-producing B cells (B10 cells) have emerged as important regulatory elements with immunosuppressive roles. Chronic lymphocytic leukemia (CLL) B cells also secrete IL-10 and share features of B10 cells, suggesting a possible contribution of CLL B cells to immunosuppression in CLL patients. Factors controlling the emergence of B10 cells are not known. B-cell-activating factor of the tumor necrosis factor (TNF) family (BAFF) is critical for B-cell maturation and survival, and is implicated in the development and progression of CLL. We sought to investigate the role of BAFF in the emergence of IL-10-producing regulatory B cells in healthy donors and CLL patients. Here, we report that BAFF signaling promotes IL-10 production by CLL B cells in a mouse model of CLL and in CLL patients. Moreover, BAFF-mediated IL-10 production by normal and CLL B cells is mediated via its receptor transmembrane activator and cyclophilin ligand interactor. Our work uncovered a major targetable pathway important for the generation of regulatory B cells that is detrimental to immunity in CLL.
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