Surgery (RMH) - Research Publications
Now showing items 1-10 of 55
Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2013-08-27)
Epithelial-mesenchymal transition (EMT) is a highly conserved morphogenic process defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. EMT is associated with increased aggressiveness, ...
Capsosomes with Multilayered Subcompartments: Assembly and Loading with Hydrophobic Cargo
(WILEY-V C H VERLAG GMBH, 2010-01-08)
Constitutive activation of the Src family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response
(ROCKEFELLER UNIV PRESS, 2002-09-02)
To identify the physiological role of Hck, a functionally redundant member of the Src family of tyrosine kinases expressed in myelomonocytic cells, we generated Hck(F/F) "knock-in" mice which carry a targeted tyrosine (Y) ...
Interleukin-1 beta has trophic effects in microglia and its release is mediated by P2X7R pore
(BIOMED CENTRAL LTD, 2016-06-30)
BACKGROUND: Enhanced expression of the purinergic P2X7 receptor (P2X7R) occurs in several neuroinflammatory conditions where increased microglial activation is a co-existing feature. P2X7 receptors can function either as ...
Total arterial coronary revascularization.
Arterial coronary grafts can be used in the majority of patients and have better patencies than saphenous vein grafts (SVGs), resulting in excellent perioperative and superior long-term outcomes. Barriers to their extensive ...
Activity Limitation in Glaucoma: Objective Assessment by the Cambridge Glaucoma Visual Function Test
(ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2016-11-01)
Purpose: We design and evaluate a computer-based objective simulation of activity limitation related to glaucoma. Methods: A cross-sectional study was performed involving 70 glaucoma patients and 14 controls. Mean age was ...
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity
(TAYLOR & FRANCIS INC, 2014-05-01)
Several agents targeting the epidermal growth factor receptor (EGFR) have been FDA-approved to treat cancer patients with varying tumor types including metastatic colorectal cancer. Many patients treated with anti-EGFR ...
Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
(AMER SOC MICROBIOLOGY, 2004-02-01)
The mechanisms by which interleukin-6 (IL-6) family cytokines, which utilize the common receptor signaling subunit gp130, influence monocyte/macrophage development remain unclear. Here we have utilized macrophages devoid ...
The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis
(BIOMED CENTRAL LTD, 2015-09-17)
BACKGROUND: The establishment and maintenance of polarity is vital for embryonic development and loss of polarity is a frequent characteristic of epithelial cancers, however the underlying molecular mechanisms remain ...