Surgery (RMH) - Theses
Now showing items 1-7 of 7
A study on the use of administrative data to create a colorectal cancer database
Colorectal cancer (CRC) is a common and life-threatening disease which contributes a significant burden on global health systems. Clinical colorectal cancer registries (CCCRs) are potentially powerful tools in the study ...
Developing novel therapies using glioma stem cells
Glioblastoma multiforme (GBM) is a heterogeneous and malignant brain tumour with poor survival. Despite current best therapies most patients die within 15 months of diagnosis. These aggressive tumours are thought to recur ...
Anatomy of the cutaneous lymphatics of the limbs and the lower trunk and its implications in the surgical treatment of lymphoedema
Background A more detailed understanding of the anatomy of the cutaneous lymphatic system is required in order to preserve its function during various procedures and to reconstruct it following its disruption. There is ...
Urinary biomarkers and integrated genomics in bladder cancer
Much remains to be elucidated regarding the molecular mechanisms driving urothelial carcinoma of the bladder (CaB). While comprehensive molecular analyses of several other cancers such as melanoma and breast cancer have ...
Alveolar macrophage Mac-1 upregulation is a hallmark of inflammatory lung diseases
Alveolar macrophages of the lung parenchyma facilitate organ homeostasis and host defence, yet are increased and activated in the lungs of patients with acute and chronic lung conditions. This paradox is attributed to the ...
Identification of genes that regulate lymphatic endothelial cell migration through siRNA screening
The lymphatic vasculature is vital for tissue fluid homeostasis. It also enables effective immune surveillance, and aids the transport and absorption of fatty acids. Damaged or faulty lymphatic vessels can lead to an ...
Differential cooperation of MAPKs with TGF-β signaling in epithelial to mesenchymal transition (EMT)
Tumor invasion and metastasis are the major causes of treatment failure in cancer patients and principal contributing factors to cancer morbidity and mortality. However, little is understood about either event at the ...