Surgery (RMH) - Theses
Now showing items 1-10 of 39
The role of quiescence in treatment resistance and malignancy in glioblastoma multiforme
Glioblastoma multiforme (GBM) represents the most malignant incarnation of glial tumours – a World Health Organisation (WHO) grade IV brain malignancy. GBM is the most common primary brain tumour in adults, accounting for ...
The impact of intensivist-performed, examination extended ultrasound in intensive care medicine
Intensivist-performed ultrasound, including transthoracic echocardiography (TTE) and to a lesser extent lung ultrasound, has been integrated into clinical practice in ICU. However, it is only used when indicated as a ...
TGF-β signaling regulation in breast cancer metastasis
The majority of cancer fatality is caused by tumor metastasis which is underlined by Epithelial-Mesenchymal-Transition (EMT) and its opposing process Mesenchymal-Epithelial-Transition (MET) at the cellular level. Transforming ...
Investigation of the role of intra- and peri-prostatic nerves in urinary continence and prostate cancer progression
Background Prostate cancer is a prevalent disease that causes significant morbidity and mortality. Although radical prostatectomy offers excellent disease control, it is associated with significant side effects in some ...
Ponatinib inhibits STAT3 activity and reduces colorectal cancer growth
Colorectal cancer is the 4th most common cancer globally and the 2nd most common cancer in Australia. Constitutive activation of Signal Transducer and Activator of Transcription 3 (STAT3) has been observed in over 50% of ...
Management of PET-avid thyroid nodules in cancer patients
Background and aims: FDG-avid thyroid incidentalomas (TI) are common findings (2.5%) in patients imaged for staging or treatment response and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ...
A study on the use of administrative data to create a colorectal cancer database
Colorectal cancer (CRC) is a common and life-threatening disease which contributes a significant burden on global health systems. Clinical colorectal cancer registries (CCCRs) are potentially powerful tools in the study ...
Biomarkers of tumour vascularity in high grade glioma
Australia has one of the highest cancer incidences in the world, and while brain cancer is a relatively rare diagnosis, its impact on the Australian healthcare system is significant. Despite being responsible for only 1.4% ...
New models of secondary lymphoedema: a common complication of cancer surgery
Secondary lymphoedema is a physically and psychologically debilitating disease caused by inadequate drainage of interstitial tissue fluid, distal to sites of damage to lymphatic vessels. It may develop after any cancer ...
The immune suppressive function of Transforming Growth Factor-β (TGF-β) in human diseases
he complex immune system has evolved to defend against pathogens while maintaining self-tolerance. Transforming growth factor-β (TGF-β) is a cytokine employed by many immune cells to suppress autoimmunity and inflammation. ...