Surgery (RMH) - Theses
Now showing items 1-10 of 45
The Genomics of Oral and Oropharyngeal Squamous Cell Carcinoma
Head and neck squamous carcinomas (HNSCCs) are a diverse group of squamous cell cancers in the upper aerodigestive tract. Whilst tobacco, alcohol, and the human papilloma virus (HPV) have been implicated in HNSCC oncogenesis, ...
Use of administrative data to create a colorectal cancer database
Background: Research into Colorectal cancer (CRC) require maintenance of clinical cancer databases with complex datasets. These are resource intensive, region specific, and compromised by reporting bias . Administrative ...
Hormonally induced defects of DNA damage repair genes: an oncogenic driver of prostate cancer
Patients with defects in the mismatch repair pathway, driven by either MSH2 or MSH6 loss, experience a significant increase in the incidence of prostate cancer, while germline mismatch repair defects in either MLH1 or PMS2, ...
Prostate cancer cell adaptation to profound androgen suppression
Androgen deprivation therapy is the mainstay of treatment for advanced prostate cancer. Although castration results in tumour regression and symptom relief in the majority of cases, the effects are short lived, with most ...
Clinical and functional characterisation of novel gene candidates for colorectal cancer
Colorectal cancer (CRC) is the third most common cancer worldwide, affecting over 15,000 individuals in Australia each year. While CRC is often detected at a stage where resection of the primary tumour is possible, ...
Investigating the evolution of structural variation in cancer
Cancers arise from single progenitor cells that acquire mutations, eventually dividing into mixed populations with distinct genotypes. These populations can be estimated by identifying common mutational profiles, using ...
The role of quiescence in treatment resistance and malignancy in glioblastoma multiforme
Glioblastoma multiforme (GBM) represents the most malignant incarnation of glial tumours – a World Health Organisation (WHO) grade IV brain malignancy. GBM is the most common primary brain tumour in adults, accounting for ...
The impact of intensivist-performed, examination extended ultrasound in intensive care medicine
Intensivist-performed ultrasound, including transthoracic echocardiography (TTE) and to a lesser extent lung ultrasound, has been integrated into clinical practice in ICU. However, it is only used when indicated as a ...
TGF-β signaling regulation in breast cancer metastasis
The majority of cancer fatality is caused by tumor metastasis which is underlined by Epithelial-Mesenchymal-Transition (EMT) and its opposing process Mesenchymal-Epithelial-Transition (MET) at the cellular level. Transforming ...
Investigation of the role of intra- and peri-prostatic nerves in urinary continence and prostate cancer progression
Background Prostate cancer is a prevalent disease that causes significant morbidity and mortality. Although radical prostatectomy offers excellent disease control, it is associated with significant side effects in some ...