Head and neck squamous carcinomas (HNSCCs) are a diverse group of squamous cell cancers in the upper aerodigestive tract. Whilst tobacco, alcohol, and the human papilloma virus (HPV) have been implicated in HNSCC oncogenesis, ...

Background: Research into Colorectal cancer (CRC) require maintenance of clinical cancer databases with complex datasets. These are resource intensive, region specific, and compromised by reporting bias [1]. Administrative ...

Patients with defects in the mismatch repair pathway, driven by either MSH2 or MSH6 loss, experience a significant increase in the incidence of prostate cancer, while germline mismatch repair defects in either MLH1 or PMS2, ...

Androgen deprivation therapy is the mainstay of treatment for advanced prostate cancer. Although castration results in tumour regression and symptom relief in the majority of cases, the effects are short lived, with most ...

Colorectal cancer (CRC) is the third most common cancer worldwide, affecting over 15,000 individuals in Australia each year. While CRC is often detected at a stage where resection of the primary tumour is possible, ...

Cancers arise from single progenitor cells that acquire mutations, eventually dividing into mixed populations with distinct genotypes. These populations can be estimated by identifying common mutational profiles, using ...

Glioblastoma multiforme (GBM) represents the most malignant incarnation of glial tumours – a World Health Organisation (WHO) grade IV brain malignancy. GBM is the most common primary brain tumour in adults, accounting for ...

Intensivist-performed ultrasound, including transthoracic echocardiography (TTE) and to a lesser extent lung ultrasound, has been integrated into clinical practice in ICU. However, it is only used when indicated as a ...

The majority of cancer fatality is caused by tumor metastasis which is underlined by Epithelial-Mesenchymal-Transition (EMT) and its opposing process Mesenchymal-Epithelial-Transition (MET) at the cellular level. Transforming ...

Background Prostate cancer is a prevalent disease that causes significant morbidity and mortality. Although radical prostatectomy offers excellent disease control, it is associated with significant side effects in some ...