Microbiology & Immunology
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(NATURE RESEARCH, 2021-03-19)T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals. Here we report ...
Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques (NATURE RESEARCH, 2021-03-03)SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies against the viral spike (S). However, the merits of broadly targeting S versus focusing antibody ...
Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages. (Springer Science and Business Media LLC, 2021-03-05)Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory ...