• Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection 

  Wang, Z; Yang, X; Zhong, J; Zhou, Y; Tang, Z; Zhou, H; He, J; Mei, X; Tang, Y; Lin, B; ... (NATURE RESEARCH, 2021-03-19)

  T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals. Here we report ...

• Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques 

  Hyon-Xhi, T; Juno, JA; Lee, WS; Barber-Axthelm, I; Kelly, HG; Wragg, KM; Esterbauer, R; Amarasena, T; Mordant, FL; Subbarao, K; ... (NATURE RESEARCH, 2021-03-03)

  SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies against the viral spike (S). However, the merits of broadly targeting S versus focusing antibody ...

• Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages. 

  Dowling, JK; Afzal, R; Gearing, LJ; Cervantes-Silva, MP; Annett, S; Davis, GM; De Santi, C; Assmann, N; Dettmer, K; Gough, DJ; ... (Springer Science and Business Media LLC, 2021-03-05)

  Mitochondria are important regulators of macrophage polarisation. Here, we show that arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein localized at the mitochondria in inflammatory ...

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