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Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population
(BIOMED CENTRAL LTD, 2013-11-06)Background The primary target of the human immune response to the malaria parasite Plasmodium falciparum, P. falciparum erythrocyte membrane protein 1 (PfEMP1), is encoded by the members of the hyper-diverse var gene family. ... -
Association of house spraying with suppressed levels of drug resistance in Zimbabwe
(BMC, 2004-10-01)BACKGROUND: Public health strategies are needed to curb antimalarial drug resistance. Theoretical argument points to an association between malaria transmission and drug resistance although field evidence remains limited. ... -
Uric Acid Is a Mediator of the Plasmodium falciparum-Induced Inflammatory Response
(PUBLIC LIBRARY SCIENCE, 2009-04-17)BACKGROUND: Malaria triggers a high inflammatory response in the host that mediates most of the associated pathologies and contributes to death. The identification of pro-inflammatory molecules derived from Plasmodium is ...