Microbiology & Immunology - Research Publications
Now showing items 1-10 of 645
Dissecting the antibody constant region protective immune parameters in HIV infection
(Future Medicine Ltd., 2014)
RV144 vaccine immune-correlates analysis has generated a renewed interest in understanding the potentially protective role of non-neutralizing antibodies in HIV infection and vaccine design. Antibodies consist of a variable ...
Complete Genome Sequence of the Frog Pathogen Mycobacterium ulcerans Ecovar Liflandii
(AMER SOC MICROBIOLOGY, 2013-02-01)
In 2004, a previously undiscovered mycobacterium resembling Mycobacterium ulcerans (the agent of Buruli ulcer) was reported in an outbreak of a lethal mycobacteriosis in a laboratory colony of the African clawed frog Xenopus ...
Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection
(PUBLIC LIBRARY SCIENCE, 2014-05-01)
Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate ...
CD8(+) T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
(PUBLIC LIBRARY SCIENCE, 2014-05-01)
To follow the fate of CD8(+) T cells responsive to Plasmodium berghei ANKA (PbA) infection, we generated an MHC I-restricted TCR transgenic mouse line against this pathogen. T cells from this line, termed PbT-I T cells, ...
Global Impact of Salmonella Pathogenicity Island 2-secreted Effectors on the Host Phosphoproteome
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2013-06-27)
During the late stages of infection, Salmonella secretes numerous effectors through a type III secretion system that is encoded within Salmonella pathogenicity island 2 (SPI2). Despite the importance of SPI2 as a major ...
Neuraminidase-Inhibiting Antibody Is a Correlate of Cross-Protection against Lethal H5N1 Influenza Virus in Ferrets Immunized with Seasonal Influenza Vaccine
(AMER SOC MICROBIOLOGY, 2013-03-27)
In preparing for the threat of a pandemic of avian H5N1 influenza virus, we need to consider the significant delay (4 to 6 months) necessary to produce a strain-matched vaccine. As some degree of cross-reactivity between ...
In Vivo IFN-gamma Secretion by NK Cells in Response to Salmonella Typhimurium Requires NLRC4 Inflammasomes
(PUBLIC LIBRARY SCIENCE, 2014)
Natural killer (NK) cells are a critical part of the innate immune defense against viral infections and for the control of tumors. Much less is known about how NK cells contribute to anti-bacterial immunity. NK cell-produced ...
Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection
(MDPI AG, 2014)
Seasonal influenza A viruses (IAV) originate from pandemic IAV and have undergone changes in antigenic structure, including addition of glycans to the hemagglutinin (HA) glycoprotein. The viral HA is the major target ...
Adaptive Change Inferred from Genomic Population Analysis of the ST93 Epidemic Clone of Community-Associated Methicillin-Resistant Staphylococcus aureus
(OXFORD UNIV PRESS, 2014)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as a major public health problem around the world. In Australia, ST93-IV[2B] is the dominant CA-MRSA clone and displays significantly ...
Natural killer T cell defects in multiple myeloma and the impact of lenalidomide therapy
The causes of multiple myeloma (MM) remain obscure and there are few known risk factors; however, natural killer T (NKT) cell abnormalities have been reported in patients with MM, and therapeutic targeting of NKT cells is ...