Microbiology & Immunology - Theses
Now showing items 1-10 of 122
Mucosal associated invariant T cell-mediated vaccination and protection against pathogenic bacteria
Mucosal Associated Invariant T (MAIT) cells are a subset of innate-like T cells, which are abundant in humans. They recognize antigens that are derived from bacterial riboflavin synthesis pathway metabolites, presented by ...
Assessment of antibody-dependent cellular cytotoxicity (ADCC) during human influenza infection, vaccination and immunotherapy
Despite the availability of influenza vaccines and antiviral therapies, human influenza virus infections cause approximately half a million deaths and five million cases of severe illness each year. Seasonal influenza ...
Human T-lymphotropic virus type-1: molecular characterization of HTLV-1 subtype C and the role of proviral load in pathogenesis in a remote Indigenous Australian setting
In Central Australia, a strain of HTLV-1 genetically different from other HTLV-1 clades is highly endemic in remote Indigenous communities, yet much remains unknown regarding HTLV-1 disease pathogenesis and why certain ...
Characterization of roles of IRF8 in dendritic cell development and function
Dendritic cells (DC) are an essential component of immune system. Antigen presentation by DCs initiates T cell responses and builds up defense against pathogens. There are two major types of DC, conventional DCs (cDCs) and ...
Transcriptional and epigenetic signatures of memory CD8+ T cell differentiation
Immunological memory is a hallmark feature of the adaptive immune system, providing superior protection against re-infection with previously encountered pathogens. Memory in CD8+ T cells is characterised by rapid effector ...
The clinical application of whole-genome sequencing to the surveillance, understanding, and control of bacterial infectious diseases in Australia
The scientific advance of whole-genome sequencing (WGS) has revolutionised the field of microbiology, with the ability to examine, characterise and compare organisms at a DNA sequence level. In recent years, the improving ...
An evaluation of charged Pam2Cys-based lipopeptides as novel adjuvants for subunit-based vaccines
The use of subunit antigens in modern vaccines generally requires the addition of an adjuvant due to the lack of immunostimulatory features that would otherwise allow them to induce strong immune responses. A problem facing ...
Strategies for the elicitation of broadly neutralising antibodies to the HIV-1 envelope protein
An effective prophylactic vaccine for HIV will likely require the elicitation of neutralising antibodies directed towards the Envelope protein (Env) of HIV. In particular, broadly neutralising antibodies (bNAbs) capable ...
Interaction of mouse norovirus (MNV) with the cellular immune response of host cells
Human noroviruses (HuNoV) cause the majority of non-bacterial gastroenteritis cases worldwide and generate an economic burden of 60 billion USD every year. Noroviruses are highly infectious and predominantly cause issues ...
Development of virus-like particles as immunogens for HIV-1 envelope glycoprotein
A prophylactic vaccine eliciting broadly neutralising antibody (bNAb) responses against HIV-1 envelope glycoprotein (Env) would be optimal to prevent HIV-1 transmission. Replication incompetent HIV-1 virus-like particles ...