Microbiology & Immunology - Theses
Now showing items 1-10 of 137
Latency reversing agents affect HIV RNA splicing
Although antiretroviral therapy (ART) has changed HIV from a death sentence to a manageable chronic illness, there is still no cure and individuals living with HIV must endure lifelong therapy and continue to face stigma ...
Investigating the impact of influenza neuraminidase on viral replication
Infection with influenza A virus remains an important issue for healthcare systems worldwide due to the direct impact of seasonal epidemics on human morbidity and mortality and also the risk of emergent pandemics. Currently, ...
The interaction of Salmonella Typhimurium with host derived lipids
Autotransporters are some of the most abundantly secreted proteins in Gram-negative bacteria. Many of these proteins function as virulence factors. S. enterica serovar Typhimurium has five autotransporter proteins: SadA; ...
Transcriptional regulation and co-stimulatory signaling in antiviral T cell immunity
Special AT-rich binding protein-1 (SATB1) is a global chromatin organizer, promoting or repressing gene transcription in mice and human. In this PhD thesis, SATB1 expression was examined in humans across ages and tissues ...
Immunity and protection against Influenza B viruses
Broad immunity to influenza viruses can be conferred by both humoral and cellular components of the immune system. Thus, universal vaccines, need to elicit both antibody and T cell responses with broad cross-reactivity ...
Variation in killer cell immunoglobulin-like receptors and their human leukocyte antigen class I-encoded ligands impacts natural killer cell education and the control of viral infection
The interaction of HLA class I (HLA-I) proteins with inhibitory receptors such as those of the Killer cell Immunoglobulin-like Receptor (KIR) family play a key role in effector function acquisition and target cell ...
The molecular regulation of tissue-resident memory T cell development
Tissue-resident memory T (Trm) cells are non-recirculating memory T cells that persist in peripheral tissues at the site of previous infection. Trm cells have been identified in many different tissues, although, factors ...
Pathways to HIV latency and reactivation in vitro
Human immunodeficiency virus (HIV) infection remains a major global health issue. Antiretroviral drugs improve life expectancy and significantly reduce the rate of viral transmission; however, we are far from finding a ...
Development of novel HIV-1 latency reversing agents
HIV-1 establishes a highly stable latent reservoir early in infection, necessitating lifelong combinational antiretroviral therapy. Elimination of the latent reservoir remains a significant roadblock for a functional HIV-1 ...
Immunoglobulin allotypes, antibody-dependent neutrophil phagocytosis: impact on HIV and influenza
Antibodies (Abs) are highly functional immune proteins. Abs can deactivate pathogens through neutralization and mediating various Fc receptor (FcR) functions. Two common FcR-mediated functions are Ab-dependent cellular ...