Reversibility of IOP-induced retinal ganglion cell injury in mice

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    Author
    Zhao, Da
    Date
    2019
    Affiliation
    Optometry and Vision Sciences
    Metadata
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    Document Type
    PhD thesis
    Access Status
    This item is embargoed and will be available on 2021-08-06. This item is currently available to University of Melbourne staff and students only, login required.
    URI
    http://hdl.handle.net/11343/227045
    Description

    © 2019 Dr. Da Zhao
    Abstract
    It is commonly believed that high eye pressure induced retinal ganglion cell injury is irreversible in glaucoma, however current studies suggest otherwise. This thesis developed a glaucoma model in mice to demonstrate that retinal ganglion cells can recover their activity, but only if intervention occurs early. The functional recovery of retinal ganglion cells is associated with changes to the purinergic pathway.
    Keywords
    glaucoma; retinal ganglion cell; IOP; function

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