Reversibility of IOP-induced retinal ganglion cell injury in mice
AffiliationOptometry and Vision Sciences
Document TypePhD thesis
Access StatusThis item is embargoed and will be available on 2021-08-06. This item is currently available to University of Melbourne staff and students only, login required.
© 2019 Dr. Da Zhao
It is commonly believed that high eye pressure induced retinal ganglion cell injury is irreversible in glaucoma, however current studies suggest otherwise. This thesis developed a glaucoma model in mice to demonstrate that retinal ganglion cells can recover their activity, but only if intervention occurs early. The functional recovery of retinal ganglion cells is associated with changes to the purinergic pathway.
Keywordsglaucoma; retinal ganglion cell; IOP; function
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