One-step radiosynthesis of 4-nitrophenyl 2-[F-18]fluoropropionate ([F-18]NFP); improved preparation of radiolabeled peptides for PET imaging
AuthorHaskali, MB; Roselt, PD; Karas, JA; Noonan, W; Wichmann, CW; Katsifis, A; Hicks, RJ; Hutton, CA
Source TitleJOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
University of Melbourne Author/sRoselt, Peter; Hicks, Rodney; Hutton, Craig; Wichmann, Christian; Haskali, Mohammad; Karas, John; Karas, John
AffiliationMedicine (St Vincent's)
School of Chemistry
Document TypeJournal Article
CitationsHaskali, M. B., Roselt, P. D., Karas, J. A., Noonan, W., Wichmann, C. W., Katsifis, A., Hicks, R. J. & Hutton, C. A. (2013). One-step radiosynthesis of 4-nitrophenyl 2-[F-18]fluoropropionate ([F-18]NFP); improved preparation of radiolabeled peptides for PET imaging. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 56 (14), pp.726-730. https://doi.org/10.1002/jlcr.3111.
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The versatile (18) F-labeled prosthetic group, 4-nitrophenyl 2-[(18) F]fluoropropionate ([(18) F]NFP), was synthesized in a single step in 45 min from 4-nitrophenyl 2-bromopropionate, with a decay corrected radiochemical yield of 26.2% ± 2.2%. Employing this improved synthesis of [(18) F]NFP, [(18) F]GalactoRGD - the current 'gold standard' tracer for imaging the expression of αV β3 integrin - was prepared with high specific activity in 90 min and 20% decay corrected radiochemical yield from [(18) F]fluoride.
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